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Items: 1 to 20 of 21


A high-throughput screening compatible assay for activators and inhibitors of methionine sulfoxide reductase A.

Brunell D, Weissbach H, Hodder P, Brot N.

Assay Drug Dev Technol. 2010 Oct;8(5):615-20. doi: 10.1089/adt.2009.0263. Epub 2010 Jun 1.


Autoantibody against one of the antioxidant repair enzymes, methionine sulfoxide reductase A, in systemic sclerosis: association with pulmonary fibrosis and vascular damage.

Ogawa F, Shimizu K, Hara T, Muroi E, Komura K, Takenaka M, Hasegawa M, Fujimoto M, Takehara K, Sato S.

Arch Dermatol Res. 2010 Jan;302(1):27-35. doi: 10.1007/s00403-009-0996-9. Epub 2009 Oct 21.


Deletion of mouse MsrA results in HBO-induced cataract: MsrA repairs mitochondrial cytochrome c.

Brennan LA, Lee W, Cowell T, Giblin F, Kantorow M.

Mol Vis. 2009 May 15;15:985-99.


Protection of vascular smooth muscle cells by over-expressed methionine sulphoxide reductase A: role of intracellular localization and substrate availability.

Haenold R, Wassef R, Brot N, Neugebauer S, Leipold E, Heinemann SH, Hoshi T.

Free Radic Res. 2008 Nov;42(11-12):978-88. doi: 10.1080/10715760802566541.


Methionine oxidation impairs reverse cholesterol transport by apolipoprotein A-I.

Shao B, Cavigiolio G, Brot N, Oda MN, Heinecke JW.

Proc Natl Acad Sci U S A. 2008 Aug 26;105(34):12224-9. doi: 10.1073/pnas.0802025105. Epub 2008 Aug 21.


Thionein can serve as a reducing agent for the methionine sulfoxide reductases.

Sagher D, Brunell D, Hejtmancik JF, Kantorow M, Brot N, Weissbach H.

Proc Natl Acad Sci U S A. 2006 Jun 6;103(23):8656-61. Epub 2006 May 30.


Methionine sulfoxide reductases B1, B2, and B3 are present in the human lens and confer oxidative stress resistance to lens cells.

Marchetti MA, Pizarro GO, Sagher D, Deamicis C, Brot N, Hejtmancik JF, Weissbach H, Kantorow M.

Invest Ophthalmol Vis Sci. 2005 Jun;46(6):2107-12.


Methionine sulfoxide reductases: history and cellular role in protecting against oxidative damage.

Weissbach H, Resnick L, Brot N.

Biochim Biophys Acta. 2005 Jan 17;1703(2):203-12. Epub 2004 Nov 11. Review.


Methionine sulfoxide reductase A protects neuronal cells against brief hypoxia/reoxygenation.

Yermolaieva O, Xu R, Schinstock C, Brot N, Weissbach H, Heinemann SH, Hoshi T.

Proc Natl Acad Sci U S A. 2004 Feb 3;101(5):1159-64. Epub 2004 Jan 26.


Structure of Mycobacterium tuberculosis methionine sulfoxide reductase A in complex with protein-bound methionine.

Taylor AB, Benglis DM Jr, Dhandayuthapani S, Hart PJ.

J Bacteriol. 2003 Jul;185(14):4119-26.


High-quality life extension by the enzyme peptide methionine sulfoxide reductase.

Ruan H, Tang XD, Chen ML, Joiner ML, Sun G, Brot N, Weissbach H, Heinemann SH, Iverson L, Wu CF, Hoshi T.

Proc Natl Acad Sci U S A. 2002 Mar 5;99(5):2748-53. Epub 2002 Feb 26. Erratum in: Proc Natl Acad Sci U S A 2002 May 14;99(10):7184. Chen, M-L [corrected to Chen, Mai-Lei]; Joiner, MA [corrected to Joiner, Mei-Ling A]; Heinemann, Stephen H [corrected to Heinemann, Stefan H].


Peptide methionine sulfoxide reductase: structure, mechanism of action, and biological function.

Weissbach H, Etienne F, Hoshi T, Heinemann SH, Lowther WT, Matthews B, St John G, Nathan C, Brot N.

Arch Biochem Biophys. 2002 Jan 15;397(2):172-8. Review.


Structure and mechanism of peptide methionine sulfoxide reductase, an "anti-oxidation" enzyme.

Lowther WT, Brot N, Weissbach H, Matthews BW.

Biochemistry. 2000 Nov 7;39(44):13307-12.


A sulfenic acid enzyme intermediate is involved in the catalytic mechanism of peptide methionine sulfoxide reductase from Escherichia coli.

Boschi-Muller S, Azza S, Sanglier-Cianferani S, Talfournier F, Van Dorsselear A, Branlant G.

J Biol Chem. 2000 Nov 17;275(46):35908-13.


Thiol-disulfide exchange is involved in the catalytic mechanism of peptide methionine sulfoxide reductase.

Lowther WT, Brot N, Weissbach H, Honek JF, Matthews BW.

Proc Natl Acad Sci U S A. 2000 Jun 6;97(12):6463-8.


Overexpression of peptide-methionine sulfoxide reductase in Saccharomyces cerevisiae and human T cells provides them with high resistance to oxidative stress.

Moskovitz J, Flescher E, Berlett BS, Azare J, Poston JM, Stadtman ER.

Proc Natl Acad Sci U S A. 1998 Nov 24;95(24):14071-5.


The yeast peptide-methionine sulfoxide reductase functions as an antioxidant in vivo.

Moskovitz J, Berlett BS, Poston JM, Stadtman ER.

Proc Natl Acad Sci U S A. 1997 Sep 2;94(18):9585-9.


Cloning the expression of a mammalian gene involved in the reduction of methionine sulfoxide residues in proteins.

Moskovitz J, Weissbach H, Brot N.

Proc Natl Acad Sci U S A. 1996 Mar 5;93(5):2095-9.

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