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Bioorg Med Chem Lett. 2012 Feb 15;22(4):1591-7. doi: 10.1016/j.bmcl.2011.12.130. Epub 2012 Jan 5.

Hit to lead evaluation of 1,2,3-triazolo[4,5-b]pyridines as PIM kinase inhibitors.

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  • 1Experimental Therapeutics Program, Spanish National Cancer Research Centre (CNIO), Madrid, Spain. jpastor@cnio.es

Abstract

PIM kinases have become targets of interest due to their association with biochemical mechanisms affecting survival, proliferation and cytokine production. 1,2,3-Triazolo[4,5-b]pyridines were identified as PIM inhibitors applying a scaffold hopping approach. Initial exploration around this scaffold and X-ray crystallographic data are hereby described.

PMID:
22266039
DOI:
10.1016/j.bmcl.2011.12.130
[PubMed - indexed for MEDLINE]

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