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Items: 5


Identification of phosphotyrosine mimetic inhibitors of human tyrosyl-DNA phosphodiesterase I by a novel AlphaScreen high-throughput assay.

Marchand C, Lea WA, Jadhav A, Dexheimer TS, Austin CP, Inglese J, Pommier Y, Simeonov A.

Mol Cancer Ther. 2009 Jan;8(1):240-8. doi: 10.1158/1535-7163.MCT-08-0878.


Tyrosyl-DNA phosphodiesterase as a target for anticancer therapy.

Dexheimer TS, Antony S, Marchand C, Pommier Y.

Anticancer Agents Med Chem. 2008 May;8(4):381-9. Review.


Quantitative high-throughput screening: a titration-based approach that efficiently identifies biological activities in large chemical libraries.

Inglese J, Auld DS, Jadhav A, Johnson RL, Simeonov A, Yasgar A, Zheng W, Austin CP.

Proc Natl Acad Sci U S A. 2006 Aug 1;103(31):11473-8.


Inhibition of human tyrosyl-DNA phosphodiesterase by aminoglycoside antibiotics and ribosome inhibitors.

Liao Z, Thibaut L, Jobson A, Pommier Y.

Mol Pharmacol. 2006 Jul;70(1):366-72.

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