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Bioorg Med Chem Lett. 2010 Jun 15;20(12):3495-8. doi: 10.1016/j.bmcl.2010.04.145. Epub 2010 May 6.

Antitrypanosomal alkaloids from Polyalthia suaveolens (Annonaceae): their effects on three selected glycolytic enzymes of Trypanosoma brucei.

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1
Department of Organic Chemistry, Faculty of Sciences, University of Yaoundé I, Yaoundé, Cameroon. nwete@yahoo.fr

Abstract

In continuation of our study on medicinal plants of Cameroon, stem barks of Polyalthia suaveolens were phytochemically studied. This investigation yielded a new indolosesquiterpene alkaloid, named polysin (1) and four hitherto known alkaloids (2-5). Polysin (1) appeared as a competitive reversible inhibitor (K(i)=10 microM) of phosphofructo kinase (PFK) of Trypanosoma brucei with respect to fructose-6-phosphate (K(i)/K(M)=0.05) and could be used in the design of new trypanocidal drugs. The other isolated compounds (2-5) also exhibited interesting inhibitory effects on selected glycolytic enzymes (PFK, glyceraldehyde-3-phosphate dehydrogenase and aldolase).

PMID:
20529682
DOI:
10.1016/j.bmcl.2010.04.145
[Indexed for MEDLINE]
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