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Bioorg Med Chem Lett. 2007 Jun 1;17(11):3208-11. Epub 2007 Mar 12.

2-hydroxy-N-arylbenzenesulfonamides as ATP-citrate lyase inhibitors.

Author information

1
Bristol-Myers Squibb Pharmaceutical Research Institute, PO Box 5400, Princeton, NJ 08543-5400, USA. James.Li@bms.com

Abstract

A novel series of 2-hydroxy-N-arylbenzenesulfonamides were identified to be ATP-citrate lyase (ACL) inhibitors with compound 9 displaying potent in vitro activity (IC(50)=0.13 microM). Chronic oral dosing of compound 9 in high-fat fed mice lowered plasma cholesterol, triglyceride, and glucose, as well as inhibited weight gain.

PMID:
17383874
DOI:
10.1016/j.bmcl.2007.03.017
[Indexed for MEDLINE]
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