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Bioorg Med Chem Lett. 2005 Nov 15;15(22):5003-6.

(4-Substituted-phenyl)-(5H-10,11-dihydro-pyrrolo [2,1-c][1,4] benzodiazepin-10-yl)-methanone derivatives as vasopressin receptor modulators.

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1
Chemical and Screening Sciences, Wyeth Research, Pearl River, NY 10965, USA. venkata@wyeth.com

Abstract

Synthesis and structure-activity relationships (SAR) of arginine vasopressin (AVP) receptor modulators are described. Potent and selective compounds are prepared when the amide linkage connecting rings A and B of VPA-985 is replaced with a bond, CO, -O-, -S-, or -SO2- bond.

PMID:
16153837
DOI:
10.1016/j.bmcl.2005.08.007
[Indexed for MEDLINE]
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