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Items: 1 to 20 of 42

1.

PHF11 promotes DSB resection, ATR signaling, and HR.

Gong Y, Handa N, Kowalczykowski SC, de Lange T.

Genes Dev. 2017 Jan 1;31(1):46-58. doi: 10.1101/gad.291807.116. Epub 2017 Jan 23.

2.

Dysfunctional telomeres induce p53-dependent and independent apoptosis to compromise cellular proliferation and inhibit tumor formation.

Wang Y, Wang X, Flores ER, Yu J, Chang S.

Aging Cell. 2016 Aug;15(4):646-60. doi: 10.1111/acel.12476. Epub 2016 Apr 26.

3.

Binding of TPP1 protein to TIN2 protein is required for POT1a,b protein-mediated telomere protection.

Frescas D, de Lange T.

J Biol Chem. 2014 Aug 29;289(35):24180-7. doi: 10.1074/jbc.M114.592592. Epub 2014 Jul 23.

4.

TRF2-tethered TIN2 can mediate telomere protection by TPP1/POT1.

Frescas D, de Lange T.

Mol Cell Biol. 2014 Apr;34(7):1349-62. doi: 10.1128/MCB.01052-13. Epub 2014 Jan 27.

5.

Super-resolution fluorescence imaging of telomeres reveals TRF2-dependent T-loop formation.

Doksani Y, Wu JY, de Lange T, Zhuang X.

Cell. 2013 Oct 10;155(2):345-356. doi: 10.1016/j.cell.2013.09.048.

6.

p16(INK4a) protects against dysfunctional telomere-induced ATR-dependent DNA damage responses.

Wang Y, Sharpless N, Chang S.

J Clin Invest. 2013 Oct;123(10):4489-501. doi: 10.1172/JCI69574. Epub 2013 Sep 16.

7.

POT1b regulates phagocytosis and NO production by modulating activity of the small GTPase Rab5.

Hagiwara M, Komatsu T, Sugiura SS, Isoda R, Tada H, Tanigawa N, Kato Y, Ishida N, Kobayashi K, Matsushita K.

Biochem Biophys Res Commun. 2013 Sep 27;439(3):413-7. doi: 10.1016/j.bbrc.2013.08.018. Epub 2013 Aug 13.

PMID:
23954637
8.

HOT1 is a mammalian direct telomere repeat-binding protein contributing to telomerase recruitment.

Kappei D, Butter F, Benda C, Scheibe M, Draškovič I, Stevense M, Novo CL, Basquin C, Araki M, Araki K, Krastev DB, Kittler R, Jessberger R, Londoño-Vallejo JA, Mann M, Buchholz F.

EMBO J. 2013 Jun 12;32(12):1681-701. doi: 10.1038/emboj.2013.105. Epub 2013 May 17.

9.

Telomeric 3' overhangs derive from resection by Exo1 and Apollo and fill-in by POT1b-associated CST.

Wu P, Takai H, de Lange T.

Cell. 2012 Jul 6;150(1):39-52. doi: 10.1016/j.cell.2012.05.026. Epub 2012 Jun 28.

10.

Essential roles for Pot1b in HSC self-renewal and survival.

Wang Y, Shen MF, Chang S.

Blood. 2011 Dec 1;118(23):6068-77. doi: 10.1182/blood-2011-06-361527. Epub 2011 Sep 23.

11.

A conditional knockout resource for the genome-wide study of mouse gene function.

Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A.

Nature. 2011 Jun 15;474(7351):337-42. doi: 10.1038/nature10163.

12.

A high-resolution anatomical atlas of the transcriptome in the mouse embryo.

Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nürnberger A, Schmidt K, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, Garcia-Calero E, Kruse S, Uhr M, Kauck C, Feng G, Milyaev N, Ong CK, Kumar L, Lam M, Semple CA, Gyenesei A, Mundlos S, Radelof U, Lehrach H, Sarmientos P, Reymond A, Davidson DR, Dollé P, Antonarakis SE, Yaspo ML, Martinez S, Baldock RA, Eichele G, Ballabio A.

PLoS Biol. 2011 Jan 18;9(1):e1000582. doi: 10.1371/journal.pbio.1000582.

13.

Telomere protection by TPP1 is mediated by POT1a and POT1b.

Kibe T, Osawa GA, Keegan CE, de Lange T.

Mol Cell Biol. 2010 Feb;30(4):1059-66. doi: 10.1128/MCB.01498-09. Epub 2009 Dec 7.

14.

The European renal genome project: an integrated approach towards understanding the genetics of kidney development and disease.

Willnow T, Antignac C, Brändli A, Christensen E, Cox R, Davidson D, Davies J, Devuyst O, Eichele G, Hastie N, Verroust P, Schedl A, Meij I.

Organogenesis. 2005 Apr;2(2):42-7.

15.

Give me a break: how telomeres suppress the DNA damage response.

Denchi EL.

DNA Repair (Amst). 2009 Sep 2;8(9):1118-26. doi: 10.1016/j.dnarep.2009.04.013. Epub 2009 May 23. Review.

PMID:
19482563
16.

Functional dissection of human and mouse POT1 proteins.

Palm W, Hockemeyer D, Kibe T, de Lange T.

Mol Cell Biol. 2009 Jan;29(2):471-82. doi: 10.1128/MCB.01352-08. Epub 2008 Oct 27.

17.

Pot1b deletion and telomerase haploinsufficiency in mice initiate an ATR-dependent DNA damage response and elicit phenotypes resembling dyskeratosis congenita.

He H, Wang Y, Guo X, Ramchandani S, Ma J, Shen MF, Garcia DA, Deng Y, Multani AS, You MJ, Chang S.

Mol Cell Biol. 2009 Jan;29(1):229-40. doi: 10.1128/MCB.01400-08. Epub 2008 Oct 20.

18.

No overt nucleosome eviction at deprotected telomeres.

Wu P, de Lange T.

Mol Cell Biol. 2008 Sep;28(18):5724-35. doi: 10.1128/MCB.01764-07. Epub 2008 Jul 14.

19.

POT of gold: modeling dyskeratosis congenita in the mouse.

Autexier C.

Genes Dev. 2008 Jul 1;22(13):1731-6. doi: 10.1101/gad.1695808.

20.

Engineered telomere degradation models dyskeratosis congenita.

Hockemeyer D, Palm W, Wang RC, Couto SS, de Lange T.

Genes Dev. 2008 Jul 1;22(13):1773-85. doi: 10.1101/gad.1679208. Epub 2008 Jun 11.

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