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Items: 1 to 20 of 213

1.

Architecture of the human interactome defines protein communities and disease networks.

Huttlin EL, Bruckner RJ, Paulo JA, Cannon JR, Ting L, Baltier K, Colby G, Gebreab F, Gygi MP, Parzen H, Szpyt J, Tam S, Zarraga G, Pontano-Vaites L, Swarup S, White AE, Schweppe DK, Rad R, Erickson BK, Obar RA, Guruharsha KG, Li K, Artavanis-Tsakonas S, Gygi SP, Harper JW.

Nature. 2017 May 25;545(7655):505-509. doi: 10.1038/nature22366. Epub 2017 May 17.

2.

PDK1 promotes the inflammatory progress of fibroblast-like synoviocytes by phosphorylating RSK2.

Sun C, Sun Y, Jiang D, Bao G, Zhu X, Xu D, Wang Y, Cui Z.

Cell Immunol. 2017 May;315:27-33. doi: 10.1016/j.cellimm.2016.10.007. Epub 2016 Nov 1.

PMID:
28314444
3.

PKCθ-Mediated PDK1 Phosphorylation Enhances T Cell Activation by Increasing PDK1 Stability.

Kang JA, Choi H, Yang T, Cho SK, Park ZY, Park SG.

Mol Cells. 2017 Jan;40(1):37-44. doi: 10.14348/molcells.2017.2236. Epub 2017 Jan 26.

4.

PDK1-SGK1 Signaling Sustains AKT-Independent mTORC1 Activation and Confers Resistance to PI3Kα Inhibition.

Castel P, Ellis H, Bago R, Toska E, Razavi P, Carmona FJ, Kannan S, Verma CS, Dickler M, Chandarlapaty S, Brogi E, Alessi DR, Baselga J, Scaltriti M.

Cancer Cell. 2016 Aug 8;30(2):229-242. doi: 10.1016/j.ccell.2016.06.004. Epub 2016 Jul 21.

5.

Claudin-18 inhibits cell proliferation and motility mediated by inhibition of phosphorylation of PDK1 and Akt in human lung adenocarcinoma A549 cells.

Shimobaba S, Taga S, Akizuki R, Hichino A, Endo S, Matsunaga T, Watanabe R, Yamaguchi M, Yamazaki Y, Sugatani J, Ikari A.

Biochim Biophys Acta. 2016 Jun;1863(6 Pt A):1170-8. doi: 10.1016/j.bbamcr.2016.02.015. Epub 2016 Feb 24.

6.
7.

A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning.

Kırlı K, Karaca S, Dehne HJ, Samwer M, Pan KT, Lenz C, Urlaub H, Görlich D.

Elife. 2015 Dec 17;4. pii: e11466. doi: 10.7554/eLife.11466.

8.

AMIGO2, a novel membrane anchor of PDK1, controls cell survival and angiogenesis via Akt activation.

Park H, Lee S, Shrestha P, Kim J, Park JA, Ko Y, Ban YH, Park DY, Ha SJ, Koh GY, Hong VS, Mochizuki N, Kim YM, Lee W, Kwon YG.

J Cell Biol. 2015 Nov 9;211(3):619-37. doi: 10.1083/jcb.201503113.

9.

PDK1 is Expressed in Ovarian Serous Carcinoma and Correlates with Improved Survival in High-grade Tumors.

Lohneis P, Darb-Esfahani S, Dietel M, Braicu I, Sehouli J, Arsenic R.

Anticancer Res. 2015 Nov;35(11):6329-34.

PMID:
26504072
10.

A human interactome in three quantitative dimensions organized by stoichiometries and abundances.

Hein MY, Hubner NC, Poser I, Cox J, Nagaraj N, Toyoda Y, Gak IA, Weisswange I, Mansfeld J, Buchholz F, Hyman AA, Mann M.

Cell. 2015 Oct 22;163(3):712-23. doi: 10.1016/j.cell.2015.09.053. Epub 2015 Oct 22.

11.
12.

Phosphoinositide-dependent kinase-1 inhibits TRAF6 ubiquitination by interrupting the formation of TAK1-TAB2 complex in TLR4 signaling.

Moon G, Kim J, Min Y, Wi SM, Shim JH, Chun E, Lee KY.

Cell Signal. 2015 Dec;27(12):2524-33. doi: 10.1016/j.cellsig.2015.09.018. Epub 2015 Sep 30.

PMID:
26432169
13.

Overexpression of 3-phosphoinositide-dependent protein kinase-1 is associated with prognosis of gastric carcinoma.

Bai X, Li P, Xie Y, Guo C, Sun Y, Xu Q, Zhao D.

Tumour Biol. 2016 Feb;37(2):2333-9. doi: 10.1007/s13277-015-4024-8. Epub 2015 Sep 15.

PMID:
26373731
14.

PDK1 induces JunB, EMT, cell migration and invasion in human gallbladder cancer.

Lian S, Shao Y, Liu H, He J, Lu W, Zhang Y, Jiang Y, Zhu J.

Oncotarget. 2015 Oct 6;6(30):29076-86. doi: 10.18632/oncotarget.4931.

15.

MiR-454 inhibited cell proliferation of human glioblastoma cells by suppressing PDK1 expression.

Fang B, Zhu J, Wang Y, Geng F, Li G.

Biomed Pharmacother. 2015 Oct;75:148-52. doi: 10.1016/j.biopha.2015.07.029. Epub 2015 Aug 18.

PMID:
26297548
16.

A Novel Inhibitor of AKT1-PDPK1 Interaction Efficiently Suppresses the Activity of AKT Pathway and Restricts Tumor Growth In Vivo.

Mäemets-Allas K, Viil J, Jaks V.

Mol Cancer Ther. 2015 Nov;14(11):2486-96. doi: 10.1158/1535-7163.MCT-15-0281. Epub 2015 Aug 20.

17.

PDK1: A signaling hub for cell migration and tumor invasion.

Gagliardi PA, di Blasio L, Primo L.

Biochim Biophys Acta. 2015 Dec;1856(2):178-88. doi: 10.1016/j.bbcan.2015.07.003. Epub 2015 Aug 1. Review.

PMID:
26238471
18.

The BioPlex Network: A Systematic Exploration of the Human Interactome.

Huttlin EL, Ting L, Bruckner RJ, Gebreab F, Gygi MP, Szpyt J, Tam S, Zarraga G, Colby G, Baltier K, Dong R, Guarani V, Vaites LP, Ordureau A, Rad R, Erickson BK, Wühr M, Chick J, Zhai B, Kolippakkam D, Mintseris J, Obar RA, Harris T, Artavanis-Tsakonas S, Sowa ME, De Camilli P, Paulo JA, Harper JW, Gygi SP.

Cell. 2015 Jul 16;162(2):425-440. doi: 10.1016/j.cell.2015.06.043.

19.

MiR-138 suppresses airway smooth muscle cell proliferation through the PI3K/AKT signaling pathway by targeting PDK1.

Liu Y, Yang K, Sun X, Fang P, Shi H, Xu J, Xie M, Li M.

Exp Lung Res. 2015;41(7):363-9. doi: 10.3109/01902148.2015.1041581. Epub 2015 Jul 7.

PMID:
26151666
20.

miR-138-1* regulates aflatoxin B1-induced malignant transformation of BEAS-2B cells by targeting PDK1.

Wang Y, Zhang Z, Wang H, Zhang Y, Ji M, Xu H, Wang C, Sun Z, Gao W, Wang SL.

Arch Toxicol. 2016 May;90(5):1239-49. doi: 10.1007/s00204-015-1551-4. Epub 2015 Jun 18.

PMID:
26084420

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