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Virology. 2010 Jun 20;402(1):26-40. doi: 10.1016/j.virol.2009.11.048. Epub 2010 Mar 29.

Broome virus, a new fusogenic Orthoreovirus species isolated from an Australian fruit bat.

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  • 1CSIRO Livestock Industries, Australian Animal Health Laboratory, Geelong, Victoria, Australia.

Abstract

This report describes the discovery and characterization of a new fusogenic orthoreovirus, Broome virus (BroV), isolated from a little red flying-fox (Pteropus scapulatus). The BroV genome consists of 10 dsRNA segments, each having a 3' terminal pentanucleotide sequence conserved amongst all members of the genus Orthoreovirus, and a unique 5' terminal pentanucleotide sequence. The smallest genome segment is bicistronic and encodes two small nonstructural proteins, one of which is a novel fusion associated small transmembrane (FAST) protein responsible for syncytium formation, but no cell attachment protein. The low amino acid sequence identity between BroV proteins and those of other orthoreoviruses (13-50%), combined with phylogenetic analyses of structural and nonstructural proteins provide evidence to support the classification of BroV in a new sixth species group within the genus Orthoreovirus.

PMID:
20350736
DOI:
10.1016/j.virol.2009.11.048
[PubMed - indexed for MEDLINE]
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