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Items: 1 to 20 of 1489

1.

Following the fate of endocytosed fibrils.

Hasegawa M, Suzuki G.

J Biol Chem. 2017 Aug 11;292(32):13498-13499. doi: 10.1074/jbc.H117.780296.

2.

Clinical Significance of PD1 and PDL1 in Human Breast Cancer.

Uhercik M, Sanders AJ, Owen S, Davies EL, Sharma AK, Jiang WG, Mokbel K.

Anticancer Res. 2017 Aug;37(8):4249-4254.

PMID:
28739716
3.

Adrenal Insufficiency Related to Anti-Programmed Death-1 Therapy.

Ariyasu R, Horiike A, Yoshizawa T, Dotsu Y, Koyama J, Saiki M, Sonoda T, Nishikawa S, Kitazono S, Yanagitani N, Nishio M.

Anticancer Res. 2017 Aug;37(8):4229-4232.

PMID:
28739711
4.

Asparagine endopeptidase cleaves α-synuclein and mediates pathologic activities in Parkinson's disease.

Zhang Z, Kang SS, Liu X, Ahn EH, Zhang Z, He L, Iuvone PM, Duong DM, Seyfried NT, Benskey MJ, Manfredsson FP, Jin L, Sun YE, Wang JZ, Ye K.

Nat Struct Mol Biol. 2017 Aug;24(8):632-642. doi: 10.1038/nsmb.3433. Epub 2017 Jul 3.

PMID:
28671665
5.

A new potential biomarker for dementia with Lewy bodies: Skin nerve α-synuclein deposits.

Donadio V, Incensi A, Rizzo G, Capellari S, Pantieri R, Stanzani Maserati M, Devigili G, Eleopra R, Defazio G, Montini F, Baruzzi A, Liguori R.

Neurology. 2017 Jul 25;89(4):318-326. doi: 10.1212/WNL.0000000000004146. Epub 2017 Jun 30.

PMID:
28667178
6.

CADPS2 gene expression is oppositely regulated by LRRK2 and alpha-synuclein.

Obergasteiger J, Überbacher C, Pramstaller PP, Hicks AA, Corti C, Volta M.

Biochem Biophys Res Commun. 2017 Aug 26;490(3):876-881. doi: 10.1016/j.bbrc.2017.06.134. Epub 2017 Jun 21.

PMID:
28647363
7.

Pressure effects on α-synuclein amyloid fibrils: An experimental investigation on their dissociation and reversible nature.

Piccirilli F, Plotegher N, Spinozzi F, Bubacco L, Mariani P, Beltramini M, Tessari I, Militello V, Perucchi A, Amenitsch H, Baldassarri E Jr, Steinhart M, Lupi S, Ortore MG.

Arch Biochem Biophys. 2017 Aug 1;627:46-55. doi: 10.1016/j.abb.2017.06.007. Epub 2017 Jun 15.

PMID:
28624352
8.

Taking a Bite Out of Amyloid: Mechanistic Insights into α-Synuclein Degradation by Cathepsin L.

McGlinchey RP, Dominah GA, Lee JC.

Biochemistry. 2017 Aug 1;56(30):3881-3884. doi: 10.1021/acs.biochem.7b00360. Epub 2017 Jun 28.

PMID:
28614652
9.

Selective imaging of internalized proteopathic α-synuclein seeds in primary neurons reveals mechanistic insight into transmission of synucleinopathies.

Karpowicz RJ Jr, Haney CM, Mihaila TS, Sandler RM, Petersson EJ, Lee VM.

J Biol Chem. 2017 Aug 11;292(32):13482-13497. doi: 10.1074/jbc.M117.780296. Epub 2017 Jun 13.

10.

Synthetic alpha-synuclein fibrils cause mitochondrial impairment and selective dopamine neurodegeneration in part via iNOS-mediated nitric oxide production.

Tapias V, Hu X, Luk KC, Sanders LH, Lee VM, Greenamyre JT.

Cell Mol Life Sci. 2017 Aug;74(15):2851-2874. doi: 10.1007/s00018-017-2541-x. Epub 2017 May 22.

PMID:
28534083
11.

Architecture of the human interactome defines protein communities and disease networks.

Huttlin EL, Bruckner RJ, Paulo JA, Cannon JR, Ting L, Baltier K, Colby G, Gebreab F, Gygi MP, Parzen H, Szpyt J, Tam S, Zarraga G, Pontano-Vaites L, Swarup S, White AE, Schweppe DK, Rad R, Erickson BK, Obar RA, Guruharsha KG, Li K, Artavanis-Tsakonas S, Gygi SP, Harper JW.

Nature. 2017 May 25;545(7655):505-509. doi: 10.1038/nature22366. Epub 2017 May 17.

12.

α-Synuclein may cross-bridge v-SNARE and acidic phospholipids to facilitate SNARE-dependent vesicle docking.

Lou X, Kim J, Hawk BJ, Shin YK.

Biochem J. 2017 Jun 6;474(12):2039-2049. doi: 10.1042/BCJ20170200.

PMID:
28495859
13.

Skin nerve phosphorylated α-synuclein deposits in idiopathic REM sleep behavior disorder.

Antelmi E, Donadio V, Incensi A, Plazzi G, Liguori R.

Neurology. 2017 May 30;88(22):2128-2131. doi: 10.1212/WNL.0000000000003989. Epub 2017 May 3.

PMID:
28468843
14.

Steady-State Kinetics of α-Synuclein Ferrireductase Activity Identifies the Catalytically Competent Species.

McDowall JS, Ntai I, Hake J, Whitley PR, Mason JM, Pudney CR, Brown DR.

Biochemistry. 2017 May 16;56(19):2497-2505. doi: 10.1021/acs.biochem.7b00257. Epub 2017 May 4.

PMID:
28452474
15.

A sensitive assay reveals structural requirements for α-synuclein fibril growth.

Dhavale DD, Tsai C, Bagchi DP, Engel LA, Sarezky J, Kotzbauer PT.

J Biol Chem. 2017 Jun 2;292(22):9034-9050. doi: 10.1074/jbc.M116.767053. Epub 2017 Apr 3.

PMID:
28373279
16.

Evaluation of clinicopathological factors in PD-1 response: derivation and validation of a prediction scale for response to PD-1 monotherapy.

Nosrati A, Tsai KK, Goldinger SM, Tumeh P, Grimes B, Loo K, Algazi AP, Nguyen-Kim TDL, Levesque M, Dummer R, Hamid O, Daud A.

Br J Cancer. 2017 Apr 25;116(9):1141-1147. doi: 10.1038/bjc.2017.70. Epub 2017 Mar 21.

PMID:
28324889
17.

The mechanism of sirtuin 2-mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease.

de Oliveira RM, Vicente Miranda H, Francelle L, Pinho R, Szegö ÉM, Martinho R, Munari F, Lázaro DF, Moniot S, Guerreiro P, Fonseca-Ornelas L, Marijanovic Z, Antas P, Gerhardt E, Enguita FJ, Fauvet B, Penque D, Pais TF, Tong Q, Becker S, Kügler S, Lashuel HA, Steegborn C, Zweckstetter M, Outeiro TF.

PLoS Biol. 2017 Mar 3;15(3):e2000374. doi: 10.1371/journal.pbio.2000374. eCollection 2017 Mar. Erratum in: PLoS Biol. 2017 Apr 5;15(4):e1002601.

18.

α-Synuclein structural features inhibit harmful polyunsaturated fatty acid oxidation, suggesting roles in neuroprotection.

De Franceschi G, Fecchio C, Sharon R, Schapira AHV, Proukakis C, Bellotti V, de Laureto PP.

J Biol Chem. 2017 Apr 28;292(17):6927-6937. doi: 10.1074/jbc.M116.765149. Epub 2017 Feb 23.

19.

Inhibition of α-Synuclein Fibril Elongation by Hsp70 Is Governed by a Kinetic Binding Competition between α-Synuclein Species.

Aprile FA, Arosio P, Fusco G, Chen SW, Kumita JR, Dhulesia A, Tortora P, Knowles TP, Vendruscolo M, Dobson CM, Cremades N.

Biochemistry. 2017 Mar 7;56(9):1177-1180. doi: 10.1021/acs.biochem.6b01178. Epub 2017 Feb 23.

PMID:
28230968
20.

An enhanced recombinant amino-terminal acetylation system and novel in vivo high-throughput screen for molecules affecting α-synuclein oligomerisation.

Eastwood TA, Baker K, Brooker HR, Frank S, Mulvihill DP.

FEBS Lett. 2017 Mar;591(6):833-841. doi: 10.1002/1873-3468.12597. Epub 2017 Mar 6.

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