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Alanine Expansions Associated with Congenital Central Hypoventilation Syndrome Impair PHOX2B Homeodomain-mediated Dimerization and Nuclear Import.

Di Lascio S, Belperio D, Benfante R, Fornasari D.

J Biol Chem. 2016 Jun 17;291(25):13375-93. doi: 10.1074/jbc.M115.679027.


Leptin Controls Parasympathetic Wiring of the Pancreas during Embryonic Life.

Croizier S, Prevot V, Bouret SG.

Cell Rep. 2016 Apr 5;15(1):36-44. doi: 10.1016/j.celrep.2016.02.088.


A cellular and molecular mosaic establishes growth and differentiation states for cranial sensory neurons.

Karpinski BA, A Bryan C, Paronett EM, Baker JL, Fernandez A, Horvath A, Maynard TM, Moody SA, LaMantia AS.

Dev Biol. 2016 Jul 15;415(2):228-41. doi: 10.1016/j.ydbio.2016.03.015.


Loss of Ptf1a Leads to a Widespread Cell-Fate Misspecification in the Brainstem, Affecting the Development of Somatosensory and Viscerosensory Nuclei.

Iskusnykh IY, Steshina EY, Chizhikov VV.

J Neurosci. 2016 Mar 2;36(9):2691-710. doi: 10.1523/JNEUROSCI.2526-15.2016.


PHOX2B Is Associated with Neuroblastoma Cell Differentiation.

Yang L, Ke XX, Xuan F, Tan J, Hou J, Wang M, Cui H, Zhang Y.

Cancer Biother Radiopharm. 2016 Mar;31(2):44-51. doi: 10.1089/cbr.2015.1952.


PHOX2A and PHOX2B are differentially regulated during retinoic acid-driven differentiation of SK-N-BE(2)C neuroblastoma cell line.

Di Lascio S, Saba E, Belperio D, Raimondi A, Lucchetti H, Fornasari D, Benfante R.

Exp Cell Res. 2016 Mar 1;342(1):62-71. doi: 10.1016/j.yexcr.2016.02.014.


Loss of the transcription factor Meis1 prevents sympathetic neurons target-field innervation and increases susceptibility to sudden cardiac death.

Bouilloux F, Thireau J, Ventéo S, Farah C, Karam S, Dauvilliers Y, Valmier J, Copeland NG, Jenkins NA, Richard S, Marmigère F.

Elife. 2016 Feb 8;5. pii: e11627. doi: 10.7554/eLife.11627.


Inactivation of Geminin in neural crest cells affects the generation and maintenance of enteric progenitor cells, leading to enteric aganglionosis.

Stathopoulou A, Natarajan D, Nikolopoulou P, Patmanidi AL, Lygerou Z, Pachnis V, Taraviras S.

Dev Biol. 2016 Jan 15;409(2):392-405. doi: 10.1016/j.ydbio.2015.11.023.


IL-1beta mediates MMP secretion and IL-1beta neosynthesis via upregulation of p22(phox) and NOX4 activity in human articular chondrocytes.

Rousset F, Hazane-Puch F, Pinosa C, Nguyen MV, Grange L, Soldini A, Rubens-Duval B, Dupuy C, Morel F, Lardy B.

Osteoarthritis Cartilage. 2015 Nov;23(11):1972-80. doi: 10.1016/j.joca.2015.02.167.


Oncologic Phenotype of Peripheral Neuroblastic Tumors Associated With PHOX2B Non-Polyalanine Repeat Expansion Mutations.

Heide S, Masliah-Planchon J, Isidor B, Guimier A, Bodet D, Coze C, Deville A, Thebault E, Pasquier CJ, Cassagnau E, Pierron G, Clément N, Schleiermacher G, Amiel J, Delattre O, Peuchmaur M, Bourdeaut F.

Pediatr Blood Cancer. 2016 Jan;63(1):71-7. doi: 10.1002/pbc.25723.


Dynamic expression of transcription factor Brn3b during mouse cranial nerve development.

Sajgo S, Ali S, Popescu O, Badea TC.

J Comp Neurol. 2016 Apr 1;524(5):1033-61. doi: 10.1002/cne.23890.


Neuronal Differentiation in Schwann Cell Lineage Underlies Postnatal Neurogenesis in the Enteric Nervous System.

Uesaka T, Nagashimada M, Enomoto H.

J Neurosci. 2015 Jul 8;35(27):9879-88. doi: 10.1523/JNEUROSCI.1239-15.2015.


miR-204 mediates post-transcriptional down-regulation of PHOX2B gene expression in neuroblastoma cells.

Bachetti T, Di Zanni E, Ravazzolo R, Ceccherini I.

Biochim Biophys Acta. 2015 Aug;1849(8):1057-65. doi: 10.1016/j.bbagrm.2015.06.008.


Genotype-phenotype relationship in Japanese patients with congenital central hypoventilation syndrome.

Shimokaze T, Sasaki A, Meguro T, Hasegawa H, Hiraku Y, Yoshikawa T, Kishikawa Y, Hayasaka K.

J Hum Genet. 2015 Sep;60(9):473-7. doi: 10.1038/jhg.2015.65.


Dysregulation of locus coeruleus development in congenital central hypoventilation syndrome.

Nobuta H, Cilio MR, Danhaive O, Tsai HH, Tupal S, Chang SM, Murnen A, Kreitzer F, Bravo V, Czeisler C, Gokozan HN, Gygli P, Bush S, Weese-Mayer DE, Conklin B, Yee SP, Huang EJ, Gray PA, Rowitch D, Otero JJ.

Acta Neuropathol. 2015 Aug;130(2):171-83. doi: 10.1007/s00401-015-1441-0.


Nkx2.2 and Nkx2.9 are the key regulators to determine cell fate of branchial and visceral motor neurons in caudal hindbrain.

Jarrar W, Dias JM, Ericson J, Arnold HH, Holz A.

PLoS One. 2015 Apr 28;10(4):e0124408. doi: 10.1371/journal.pone.0124408.


The retrotrapezoid nucleus neurons expressing Atoh1 and Phox2b are essential for the respiratory response to CO₂.

Ruffault PL, D'Autréaux F, Hayes JA, Nomaksteinsky M, Autran S, Fujiyama T, Hoshino M, Hägglund M, Kiehn O, Brunet JF, Fortin G, Goridis C.

Elife. 2015 Apr 13;4. doi: 10.7554/eLife.07051.


Generation of a Nkx2.2(Cre) knock-in mouse line: Analysis of cell lineages in the central nervous system.

Jarrar W, Vauti F, Arnold HH, Holz A.

Differentiation. 2015 Mar-Apr;89(3-4):70-6. doi: 10.1016/j.diff.2015.03.001.


Diagnostic utility of PHOX2B in primary and treated neuroblastoma and in neuroblastoma metastatic to the bone marrow.

Hata JL, Correa H, Krishnan C, Esbenshade AJ, Black JO, Chung DH, Mobley BC.

Arch Pathol Lab Med. 2015 Apr;139(4):543-6. doi: 10.5858/arpa.2014-0255-OA.

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