Abstract
The accuracy of LiPA 2.0 for hepatitis C virus 1 (HCV-1) subtype classification was analyzed. LiPA 2.0 genotype results from 101 HCV-1-infected patients were compared to genotype findings determined by direct core sequencing. Eleven (11%) samples were misclassified. Given the influence of the HCV-1-subtype in the anti-HCV therapy response, an alternative classification method is warranted.
Copyright © 2014, American Society for Microbiology. All Rights Reserved.
Publication types
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Comparative Study
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Evaluation Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Antiviral Agents / therapeutic use*
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Female
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Genotype
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Hepacivirus / classification*
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Hepacivirus / genetics*
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Hepacivirus / isolation & purification
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Hepatitis C, Chronic / drug therapy
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Hepatitis C, Chronic / virology*
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Humans
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Male
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Middle Aged
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Molecular Sequence Data
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RNA, Viral / genetics
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Sequence Analysis, DNA
Substances
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Antiviral Agents
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RNA, Viral
Associated data
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GENBANK/KJ739737
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GENBANK/KJ739738
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GENBANK/KJ739739
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GENBANK/KJ739740
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