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Items: 1 to 20 of 410


TSC1 regulates the balance between effector and regulatory T cells.

Park Y, Jin HS, Lopez J, Elly C, Kim G, Murai M, Kronenberg M, Liu YC.

J Clin Invest. 2013 Dec;123(12):5165-78. doi: 10.1172/JCI69751. Epub 2013 Nov 25.


Crystal structure of the yeast TSC1 core domain and implications for tuberous sclerosis pathological mutations.

Sun W, Zhu YJ, Wang Z, Zhong Q, Gao F, Lou J, Gong W, Xu W.

Nat Commun. 2013;4:2135. doi: 10.1038/ncomms3135.


Timing of mTOR activation affects tuberous sclerosis complex neuropathology in mouse models.

Magri L, Cominelli M, Cambiaghi M, Cursi M, Leocani L, Minicucci F, Poliani PL, Galli R.

Dis Model Mech. 2013 Sep;6(5):1185-97. doi: 10.1242/dmm.012096. Epub 2013 Jun 5.


Excitatory/inhibitory synaptic imbalance leads to hippocampal hyperexcitability in mouse models of tuberous sclerosis.

Bateup HS, Johnson CA, Denefrio CL, Saulnier JL, Kornacker K, Sabatini BL.

Neuron. 2013 May 8;78(3):510-22. doi: 10.1016/j.neuron.2013.03.017.


Inhibition of AMPK catabolic action by GSK3.

Suzuki T, Bridges D, Nakada D, Skiniotis G, Morrison SJ, Lin JD, Saltiel AR, Inoki K.

Mol Cell. 2013 May 9;50(3):407-19. doi: 10.1016/j.molcel.2013.03.022. Epub 2013 Apr 25.


Sustained activation of mTORC1 in skeletal muscle inhibits constitutive and starvation-induced autophagy and causes a severe, late-onset myopathy.

Castets P, Lin S, Rion N, Di Fulvio S, Romanino K, Guridi M, Frank S, Tintignac LA, Sinnreich M, Rüegg MA.

Cell Metab. 2013 May 7;17(5):731-44. doi: 10.1016/j.cmet.2013.03.015. Epub 2013 Apr 18.


Conditional deletion of Tsc1 in the female reproductive tract impedes normal oviductal and uterine function by enhancing mTORC1 signaling in mice.

Daikoku T, Yoshie M, Xie H, Sun X, Cha J, Ellenson LH, Dey SK.

Mol Hum Reprod. 2013 Jul;19(7):463-72. doi: 10.1093/molehr/gat016. Epub 2013 Mar 7.


Vigabatrin inhibits seizures and mTOR pathway activation in a mouse model of tuberous sclerosis complex.

Zhang B, McDaniel SS, Rensing NR, Wong M.

PLoS One. 2013;8(2):e57445. doi: 10.1371/journal.pone.0057445. Epub 2013 Feb 20.


Tsc1 (hamartin) confers neuroprotection against ischemia by inducing autophagy.

Papadakis M, Hadley G, Xilouri M, Hoyte LC, Nagel S, McMenamin MM, Tsaknakis G, Watt SM, Drakesmith CW, Chen R, Wood MJ, Zhao Z, Kessler B, Vekrellis K, Buchan AM.

Nat Med. 2013 Mar;19(3):351-7. doi: 10.1038/nm.3097. Epub 2013 Feb 24.


TSC1 involvement in bladder cancer: diverse effects and therapeutic implications.

Guo Y, Chekaluk Y, Zhang J, Du J, Gray NS, Wu CL, Kwiatkowski DJ.

J Pathol. 2013 May;230(1):17-27. doi: 10.1002/path.4176. Epub 2013 Mar 21.


TSC1 controls distribution of actin fibers through its effect on function of Rho family of small GTPases and regulates cell migration and polarity.

Ohsawa M, Kobayashi T, Okura H, Igarashi T, Mizuguchi M, Hino O.

PLoS One. 2013;8(1):e54503. doi: 10.1371/journal.pone.0054503. Epub 2013 Jan 23.


Specific disruption of Tsc1 in ovarian granulosa cells promotes ovulation and causes progressive accumulation of corpora lutea.

Huang L, Wang ZB, Jiang ZZ, Hu MW, Lin F, Zhang QH, Luo YB, Hou Y, Zhao Y, Fan HY, Schatten H, Sun QY.

PLoS One. 2013;8(1):e54052. doi: 10.1371/journal.pone.0054052. Epub 2013 Jan 15.


Molecular profiling of activated neurons by phosphorylated ribosome capture.

Knight ZA, Tan K, Birsoy K, Schmidt S, Garrison JL, Wysocki RW, Emiliano A, Ekstrand MI, Friedman JM.

Cell. 2012 Nov 21;151(5):1126-37. doi: 10.1016/j.cell.2012.10.039.


Pediatric glioma-associated KIAA1549:BRAF expression regulates neuroglial cell growth in a cell type-specific and mTOR-dependent manner.

Kaul A, Chen YH, Emnett RJ, Dahiya S, Gutmann DH.

Genes Dev. 2012 Dec 1;26(23):2561-6. doi: 10.1101/gad.200907.112. Epub 2012 Nov 14.


Genome sequencing identifies a basis for everolimus sensitivity.

Iyer G, Hanrahan AJ, Milowsky MI, Al-Ahmadie H, Scott SN, Janakiraman M, Pirun M, Sander C, Socci ND, Ostrovnaya I, Viale A, Heguy A, Peng L, Chan TA, Bochner B, Bajorin DF, Berger MF, Taylor BS, Solit DB.

Science. 2012 Oct 12;338(6104):221. doi: 10.1126/science.1226344. Epub 2012 Aug 23.


Tumor suppressor TSC1 is critical for T-cell anergy.

Xie DL, Wu J, Lou YL, Zhong XP.

Proc Natl Acad Sci U S A. 2012 Aug 28;109(35):14152-7. doi: 10.1073/pnas.1119744109. Epub 2012 Aug 13.


Autistic-like behaviour and cerebellar dysfunction in Purkinje cell Tsc1 mutant mice.

Tsai PT, Hull C, Chu Y, Greene-Colozzi E, Sadowski AR, Leech JM, Steinberg J, Crawley JN, Regehr WG, Sahin M.

Nature. 2012 Aug 30;488(7413):647-51. doi: 10.1038/nature11310.


Regulation of mast cell survival and function by tuberous sclerosis complex 1.

Shin J, Pan H, Zhong XP.

Blood. 2012 Apr 5;119(14):3306-14. doi: 10.1182/blood-2011-05-353342. Epub 2012 Feb 23.


Functional assessment of TSC1 missense variants identified in individuals with tuberous sclerosis complex.

Hoogeveen-Westerveld M, Ekong R, Povey S, Karbassi I, Batish SD, den Dunnen JT, van Eeghen A, Thiele E, Mayer K, Dies K, Wen L, Thompson C, Sparagana SP, Davies P, Aalfs C, van den Ouweland A, Halley D, Nellist M.

Hum Mutat. 2012 Mar;33(3):476-9. doi: 10.1002/humu.22007. Epub 2012 Jan 17.


Postnatal neurogenesis generates heterotopias, olfactory micronodules and cortical infiltration following single-cell Tsc1 deletion.

Feliciano DM, Quon JL, Su T, Taylor MM, Bordey A.

Hum Mol Genet. 2012 Feb 15;21(4):799-810. doi: 10.1093/hmg/ddr511. Epub 2011 Nov 7.

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