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Items: 1 to 20 of 699

1.

Gene dosage of Otx2 is important for fertility in male mice.

Larder R, Kimura I, Meadows J, Clark DD, Mayo S, Mellon PL.

Mol Cell Endocrinol. 2013 Sep 5;377(1-2):16-22. doi: 10.1016/j.mce.2013.06.026. Epub 2013 Jun 27.

2.

Autosomal dominant oculoauriculovertebral spectrum and 14q23.1 microduplication.

Ballesta-Martínez MJ, López-González V, Dulcet LA, Rodríguez-Santiago B, Garcia-Miñaúr S, Guillen-Navarro E.

Am J Med Genet A. 2013 Aug;161A(8):2030-5. doi: 10.1002/ajmg.a.36007. Epub 2013 Jun 21.

PMID:
23794319
3.

Loss of Otx2 in the adult retina disrupts retinal pigment epithelium function, causing photoreceptor degeneration.

Housset M, Samuel A, Ettaiche M, Bemelmans A, Béby F, Billon N, Lamonerie T.

J Neurosci. 2013 Jun 12;33(24):9890-904. doi: 10.1523/JNEUROSCI.1099-13.2013. Erratum in: J Neurosci. 2014 Apr 16;34(16):5732.

4.

Specific expression pattern of a novel Otx2 splicing variant during neural differentiation.

Liu Z, Chi L, Fang Y, Liu L, Zhang X.

Gene. 2013 Jul 1;523(1):33-8. doi: 10.1016/j.gene.2013.03.114. Epub 2013 Apr 5.

PMID:
23566845
5.

OTX2 sustains a bivalent-like state of OTX2-bound promoters in medulloblastoma by maintaining their H3K27me3 levels.

Bunt J, Hasselt NA, Zwijnenburg DA, Koster J, Versteeg R, Kool M.

Acta Neuropathol. 2013 Mar;125(3):385-94. doi: 10.1007/s00401-012-1069-2. Epub 2012 Nov 18.

PMID:
23179372
6.

Otx2 is involved in the regional specification of the developing retinal pigment epithelium by preventing the expression of sox2 and fgf8, factors that induce neural retina differentiation.

Nishihara D, Yajima I, Tabata H, Nakai M, Tsukiji N, Katahira T, Takeda K, Shibahara S, Nakamura H, Yamamoto H.

PLoS One. 2012;7(11):e48879. doi: 10.1371/journal.pone.0048879. Epub 2012 Nov 8.

7.

Brain development is a multi-level regulated process--the case of the OTX2 gene.

Gat-Yablonski G.

Pediatr Endocrinol Rev. 2011 Sep;9(1):422-30. Review.

PMID:
22783640
8.

Otx2 binding to perineuronal nets persistently regulates plasticity in the mature visual cortex.

Beurdeley M, Spatazza J, Lee HH, Sugiyama S, Bernard C, Di Nardo AA, Hensch TK, Prochiantz A.

J Neurosci. 2012 Jul 4;32(27):9429-37. doi: 10.1523/JNEUROSCI.0394-12.2012.

9.

A novel OTX2 mutation in a patient with combined pituitary hormone deficiency, pituitary malformation, and an underdeveloped left optic nerve.

Gorbenko Del Blanco D, Romero CJ, Diaczok D, de Graaff LC, Radovick S, Hokken-Koelega AC.

Eur J Endocrinol. 2012 Sep;167(3):441-52. doi: 10.1530/EJE-12-0333. Epub 2012 Jun 19.

PMID:
22715480
10.

Aberrant Otx2 expression enhances migration and induces ectopic proliferation of hindbrain neuronal progenitor cells.

Wortham M, Jin G, Sun JL, Bigner DD, He Y, Yan H.

PLoS One. 2012;7(4):e36211. doi: 10.1371/journal.pone.0036211. Epub 2012 Apr 27.

11.

Novel OTX2 mutation associated with congenital anophthalmia and microphthalmia in a Han Chinese family.

You T, Lv Y, Liu S, Li F, Zhao Y, Lv J, Qiu G, Li-Ling J.

Acta Ophthalmol. 2012 Sep;90(6):e501-2. doi: 10.1111/j.1755-3768.2011.02345.x. Epub 2012 Jan 23. No abstract available.

12.

OTX2 directly activates cell cycle genes and inhibits differentiation in medulloblastoma cells.

Bunt J, Hasselt NE, Zwijnenburg DA, Hamdi M, Koster J, Versteeg R, Kool M.

Int J Cancer. 2012 Jul 15;131(2):E21-32. doi: 10.1002/ijc.26474. Epub 2011 Nov 8.

13.

Identification of a retina-specific Otx2 enhancer element active in immature developing photoreceptors.

Emerson MM, Cepko CL.

Dev Biol. 2011 Dec 1;360(1):241-55. doi: 10.1016/j.ydbio.2011.09.012. Epub 2011 Sep 21.

14.

Deletion of Otx2 in GnRH neurons results in a mouse model of hypogonadotropic hypogonadism.

Diaczok D, DiVall S, Matsuo I, Wondisford FE, Wolfe AM, Radovick S.

Mol Endocrinol. 2011 May;25(5):833-46. doi: 10.1210/me.2010-0271. Epub 2011 Mar 24.

15.

Regulation of cell cycle genes and induction of senescence by overexpression of OTX2 in medulloblastoma cell lines.

Bunt J, de Haas TG, Hasselt NE, Zwijnenburg DA, Koster J, Versteeg R, Kool M.

Mol Cancer Res. 2010 Oct;8(10):1344-57. doi: 10.1158/1541-7786.MCR-09-0546. Epub 2010 Sep 13.

16.

Otx2 gene deletion in adult mouse retina induces rapid RPE dystrophy and slow photoreceptor degeneration.

Béby F, Housset M, Fossat N, Le Greneur C, Flamant F, Godement P, Lamonerie T.

PLoS One. 2010 Jul 21;5(7):e11673. doi: 10.1371/journal.pone.0011673.

17.

Evaluation of retinoic acid therapy for OTX2-positive medulloblastomas.

Bai R, Siu IM, Tyler BM, Staedtke V, Gallia GL, Riggins GJ.

Neuro Oncol. 2010 Jul;12(7):655-63. doi: 10.1093/neuonc/nop062. Epub 2010 Feb 5.

18.

OTX2 microphthalmia syndrome: four novel mutations and delineation of a phenotype.

Schilter KF, Schneider A, Bardakjian T, Soucy JF, Tyler RC, Reis LM, Semina EV.

Clin Genet. 2011 Feb;79(2):158-68. doi: 10.1111/j.1399-0004.2010.01450.x.

19.

A novel loss-of-function mutation in OTX2 in a patient with anophthalmia and isolated growth hormone deficiency.

Ashkenazi-Hoffnung L, Lebenthal Y, Wyatt AW, Ragge NK, Dateki S, Fukami M, Ogata T, Phillip M, Gat-Yablonski G.

Hum Genet. 2010 Jun;127(6):721-9. doi: 10.1007/s00439-010-0820-9. Epub 2010 Apr 16.

PMID:
20396904
20.

OTX2 is critical for the maintenance and progression of Shh-independent medulloblastomas.

Adamson DC, Shi Q, Wortham M, Northcott PA, Di C, Duncan CG, Li J, McLendon RE, Bigner DD, Taylor MD, Yan H.

Cancer Res. 2010 Jan 1;70(1):181-91. doi: 10.1158/0008-5472.CAN-09-2331. Epub 2009 Dec 22.

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