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Items: 16

1.

The cMyBP-C HCM variant L348P enhances thin filament activation through an increased shift in tropomyosin position.

Mun JY, Kensler RW, Harris SP, Craig R.

J Mol Cell Cardiol. 2016 Feb;91:141-7. doi: 10.1016/j.yjmcc.2015.12.014. Epub 2015 Dec 21.

2.

Structure of the F-actin-tropomyosin complex.

von der Ecken J, Müller M, Lehman W, Manstein DJ, Penczek PA, Raunser S.

Nature. 2015 Mar 5;519(7541):114-7. doi: 10.1038/nature14033. Epub 2014 Dec 1.

3.

Tropomyosin is required for cardiac morphogenesis, myofibril assembly, and formation of adherens junctions in the developing mouse embryo.

McKeown CR, Nowak RB, Gokhin DS, Fowler VM.

Dev Dyn. 2014 Jun;243(6):800-17. doi: 10.1002/dvdy.24115. Epub 2014 Feb 24.

4.

Decreasing tropomyosin phosphorylation rescues tropomyosin-induced familial hypertrophic cardiomyopathy.

Schulz EM, Wilder T, Chowdhury SA, Sheikh HN, Wolska BM, Solaro RJ, Wieczorek DF.

J Biol Chem. 2013 Oct 4;288(40):28925-35. doi: 10.1074/jbc.M113.466466. Epub 2013 Aug 19.

5.

Conserved Asp-137 is important for both structure and regulatory functions of cardiac α-tropomyosin (α-TM) in a novel transgenic mouse model expressing α-TM-D137L.

Yar S, Chowdhury SA, Davis RT 3rd, Kobayashi M, Monasky MM, Rajan S, Wolska BM, Gaponenko V, Kobayashi T, Wieczorek DF, Solaro RJ.

J Biol Chem. 2013 Jun 7;288(23):16235-46. doi: 10.1074/jbc.M113.458695. Epub 2013 Apr 22.

6.

Tropomyosin Ser-283 pseudo-phosphorylation slows myofibril relaxation.

Nixon BR, Liu B, Scellini B, Tesi C, Piroddi N, Ogut O, Solaro RJ, Ziolo MT, Janssen PM, Davis JP, Poggesi C, Biesiadecki BJ.

Arch Biochem Biophys. 2013 Jul 1;535(1):30-8. doi: 10.1016/j.abb.2012.11.010. Epub 2012 Dec 8.

7.

Tropomyosin dephosphorylation results in compensated cardiac hypertrophy.

Schulz EM, Correll RN, Sheikh HN, Lofrano-Alves MS, Engel PL, Newman G, Schultz Jel J, Molkentin JD, Wolska BM, Solaro RJ, Wieczorek DF.

J Biol Chem. 2012 Dec 28;287(53):44478-89. doi: 10.1074/jbc.M112.402040. Epub 2012 Nov 12.

8.

Expression of tropomyosin-κ induces dilated cardiomyopathy and depresses cardiac myofilament tension by mechanisms involving cross-bridge dependent activation and altered tropomyosin phosphorylation.

Karam CN, Warren CM, Rajan S, de Tombe PP, Wieczorek DF, Solaro RJ.

J Muscle Res Cell Motil. 2011 Mar;31(5-6):315-22. doi: 10.1007/s10974-010-9237-2. Epub 2011 Jan 9.

9.

Rescue of tropomyosin-induced familial hypertrophic cardiomyopathy mice by transgenesis.

Jagatheesan G, Rajan S, Petrashevskaya N, Schwartz A, Boivin G, Arteaga GM, Solaro RJ, Liggett SB, Wieczorek DF.

Am J Physiol Heart Circ Physiol. 2007 Aug;293(2):H949-58. Epub 2007 Apr 6.

10.

p38-MAPK induced dephosphorylation of alpha-tropomyosin is associated with depression of myocardial sarcomeric tension and ATPase activity.

Vahebi S, Ota A, Li M, Warren CM, de Tombe PP, Wang Y, Solaro RJ.

Circ Res. 2007 Feb 16;100(3):408-15. Epub 2007 Jan 18.

11.

Charged residue alterations in the inner-core domain and carboxy-terminus of alpha-tropomyosin differentially affect mouse cardiac muscle contractility.

Gaffin RD, Tong CW, Zawieja DC, Hewett TE, Klevitsky R, Robbins J, Muthuchamy M.

J Physiol. 2004 Dec 15;561(Pt 3):777-91. Epub 2004 Oct 14.

12.

Charged residue changes in the carboxy-terminus of alpha-tropomyosin alter mouse cardiac muscle contractility.

Gaffin RD, Gokulan K, Sacchettini JC, Hewett T, Klevitsky R, Robbins J, Muthuchamy M.

J Physiol. 2004 Apr 15;556(Pt 2):531-43. Epub 2004 Feb 6.

13.

N terminus is essential for tropomyosin functions: N-terminal modification disrupts stress fiber organization and abolishes anti-oncogenic effects of tropomyosin-1.

Bharadwaj S, Hitchcock-DeGregori S, Thorburn A, Prasad GL.

J Biol Chem. 2004 Apr 2;279(14):14039-48. Epub 2004 Jan 12.

14.

The PTB interacting protein raver1 regulates alpha-tropomyosin alternative splicing.

Gromak N, Rideau A, Southby J, Scadden AD, Gooding C, Hüttelmaier S, Singer RH, Smith CW.

EMBO J. 2003 Dec 1;22(23):6356-64.

15.

A mouse model of familial hypertrophic cardiomyopathy caused by a alpha-tropomyosin mutation.

Prabhakar R, Petrashevskaya N, Schwartz A, Aronow B, Boivin GP, Molkentin JD, Wieczorek DF.

Mol Cell Biochem. 2003 Sep;251(1-2):33-42.

PMID:
14575301
16.

Altered signaling surrounding the C-lobe of cardiac troponin C in myofilaments containing an alpha-tropomyosin mutation linked to familial hypertrophic cardiomyopathy.

Burkart EM, Arteaga GM, Sumandea MP, Prabhakar R, Wieczorek DF, Solaro RJ.

J Mol Cell Cardiol. 2003 Oct;35(10):1285-93.

PMID:
14519438

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