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Items: 1 to 20 of 84

1.

PKA-mediated Gli2 and Gli3 phosphorylation is inhibited by Hedgehog signaling in cilia and reduced in Talpid3 mutant.

Li J, Wang C, Wu C, Cao T, Xu G, Meng Q, Wang B.

Dev Biol. 2017 Sep 1;429(1):147-157. doi: 10.1016/j.ydbio.2017.06.035. Epub 2017 Jul 1.

PMID:
28673820
2.

Novel Molecular Mechanism of Regulation of CD40 Ligand by the Transcription Factor GLI2.

Han W, Jackson DA, Matissek SJ, Misurelli JA, Neil MS, Sklavanitis B, Amarsaikhan N, Elsawa SF.

J Immunol. 2017 Jun 1;198(11):4481-4489. doi: 10.4049/jimmunol.1601490. Epub 2017 May 1.

PMID:
28461568
3.

Cilia-dependent GLI processing in neural crest cells is required for tongue development.

Millington G, Elliott KH, Chang YT, Chang CF, Dlugosz A, Brugmann SA.

Dev Biol. 2017 Apr 15;424(2):124-137. doi: 10.1016/j.ydbio.2017.02.021. Epub 2017 Mar 9.

4.

Stromal Gli2 activity coordinates a niche signaling program for mammary epithelial stem cells.

Zhao C, Cai S, Shin K, Lim A, Kalisky T, Lu WJ, Clarke MF, Beachy PA.

Science. 2017 Apr 21;356(6335). pii: eaal3485. doi: 10.1126/science.aal3485. Epub 2017 Mar 9.

PMID:
28280246
5.

Suppressor of Fused Chaperones Gli Proteins To Generate Transcriptional Responses to Sonic Hedgehog Signaling.

Zhang Z, Shen L, Law K, Zhang Z, Liu X, Hua H, Li S, Huang H, Yue S, Hui CC, Cheng SY.

Mol Cell Biol. 2017 Jan 19;37(3). pii: e00421-16. doi: 10.1128/MCB.00421-16. Print 2017 Feb 1.

6.

Adult Gli2+/-;Gli3Δ699/+ Male and Female Mice Display a Spectrum of Genital Malformation.

He F, Akbari P, Mo R, Zhang JJ, Hui CC, Kim PC, Farhat WA.

PLoS One. 2016 Nov 4;11(11):e0165958. doi: 10.1371/journal.pone.0165958. eCollection 2016.

7.

Craniofacial Ciliopathies Reveal Specific Requirements for GLI Proteins during Development of the Facial Midline.

Chang CF, Chang YT, Millington G, Brugmann SA.

PLoS Genet. 2016 Nov 1;12(11):e1006351. doi: 10.1371/journal.pgen.1006351. eCollection 2016 Nov.

8.

Gli Transcription Factors Mediate the Oncogenic Transformation of Prostate Basal Cells Induced by a Kras-Androgen Receptor Axis.

Wu M, Ingram L, Tolosa EJ, Vera RE, Li Q, Kim S, Ma Y, Spyropoulos DD, Beharry Z, Huang J, Fernandez-Zapico ME, Cai H.

J Biol Chem. 2016 Dec 2;291(49):25749-25760. Epub 2016 Oct 19.

9.

Gli2 gene-environment interactions contribute to the etiological complexity of holoprosencephaly: evidence from a mouse model.

Heyne GW, Everson JL, Ansen-Wilson LJ, Melberg CG, Fink DM, Parins KF, Doroodchi P, Ulschmid CM, Lipinski RJ.

Dis Model Mech. 2016 Nov 1;9(11):1307-1315. Epub 2016 Sep 1.

10.

Gli2 protein expression level is a feasible marker of ligand-dependent hedgehog activation in pancreatic neoplasms.

Sugiyama Y, Sasajima J, Mizukami Y, Koizumi K, Kawamoto T, Ono Y, Karasaki H, Tanabe H, Fujiya M, Kohgo Y.

Pol J Pathol. 2016 Jun;67(2):136-44.

11.

Suppressor of Fused Is Critical for Maintenance of Neuronal Progenitor Identity during Corticogenesis.

Yabut OR, Fernandez G, Huynh T, Yoon K, Pleasure SJ.

Cell Rep. 2015 Sep 29;12(12):2021-34. doi: 10.1016/j.celrep.2015.08.031. Epub 2015 Sep 17.

12.

Modulation of the IL-6 Receptor α Underlies GLI2-Mediated Regulation of Ig Secretion in Waldenström Macroglobulinemia Cells.

Jackson DA, Smith TD, Amarsaikhan N, Han W, Neil MS, Boi SK, Vrabel AM, Tolosa EJ, Almada LL, Fernandez-Zapico ME, Elsawa SF.

J Immunol. 2015 Sep 15;195(6):2908-16. doi: 10.4049/jimmunol.1402974. Epub 2015 Aug 3.

13.

Pharmacological GLI2 inhibition prevents myofibroblast cell-cycle progression and reduces kidney fibrosis.

Kramann R, Fleig SV, Schneider RK, Fabian SL, DiRocco DP, Maarouf O, Wongboonsin J, Ikeda Y, Heckl D, Chang SL, Rennke HG, Waikar SS, Humphreys BD.

J Clin Invest. 2015 Aug 3;125(8):2935-51. doi: 10.1172/JCI74929. Epub 2015 Jul 20.

14.

Fuzzy modeling reveals a dynamic self-sustaining network of the GLI transcription factors controlling important metabolic regulators in adult mouse hepatocytes.

Schmidt-Heck W, Matz-Soja M, Aleithe S, Marbach E, Guthke R, Gebhardt R.

Mol Biosyst. 2015 Aug;11(8):2190-7. doi: 10.1039/c5mb00129c.

PMID:
26010061
15.

MicroRNAs Promote Granule Cell Expansion in the Cerebellum Through Gli2.

Constantin L, Wainwright BJ.

Cerebellum. 2015 Dec;14(6):688-98. doi: 10.1007/s12311-015-0672-x.

PMID:
25910616
16.

The transcriptional activator Gli2 modulates T-cell receptor signalling through attenuation of AP-1 and NFκB activity.

Furmanski AL, Barbarulo A, Solanki A, Lau CI, Sahni H, Saldana JI, D'Acquisto F, Crompton T.

J Cell Sci. 2015 Jun 1;128(11):2085-95. doi: 10.1242/jcs.165803. Epub 2015 Apr 23.

17.

The loss of Hh responsiveness by a non-ciliary Gli2 variant.

Liu J, Zeng H, Liu A.

Development. 2015 May 1;142(9):1651-60. doi: 10.1242/dev.119669. Epub 2015 Apr 1.

18.

Ptch1 and Gli regulate Shh signalling dynamics via multiple mechanisms.

Cohen M, Kicheva A, Ribeiro A, Blassberg R, Page KM, Barnes CP, Briscoe J.

Nat Commun. 2015 Apr 2;6:6709. doi: 10.1038/ncomms7709.

19.

Sonic hedgehog through Gli2 and Gli3 is required for the proper development of placental labyrinth.

Pan YB, Gong Y, Ruan HF, Pan LY, Wu XK, Tang C, Wang CJ, Zhu HB, Zhang ZM, Tang LF, Zou CC, Wang HB, Wu XM.

Cell Death Dis. 2015 Feb 19;6:e1653. doi: 10.1038/cddis.2015.28.

20.

The sonic hedgehog-induced type 3 deiodinase facilitates tumorigenesis of basal cell carcinoma by reducing Gli2 inactivation.

Luongo C, Ambrosio R, Salzano S, Dlugosz AA, Missero C, Dentice M.

Endocrinology. 2014 Jun;155(6):2077-88. doi: 10.1210/en.2013-2108. Epub 2014 Apr 2.

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