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A metal-based inhibitor of NEDD8-activating enzyme.

Zhong HJ, Yang H, Chan DS, Leung CH, Wang HM, Ma DL.

PLoS One. 2012;7(11):e49574. doi: 10.1371/journal.pone.0049574. Epub 2012 Nov 19.


Amyloid precursor protein binding protein-1 knockdown reduces neuronal differentiation in fetal neural stem cells.

Hong BH, Ha S, Joo Y, Kim JA, Chang KA, Woo RS, Suh YH, Kim JH, Kim HS.

Neuroreport. 2012 Jan 25;23(2):61-6. doi: 10.1097/WNR.0b013e32834e7d4f.


Inhibition of Neddylation Modification Sensitizes Pancreatic Cancer Cells to Gemcitabine.

Li H, Zhou W, Li L, Wu J, Liu X, Zhao L, Jia L, Sun Y.

Neoplasia. 2017 Jun;19(6):509-518. doi: 10.1016/j.neo.2017.04.003. Epub 2017 May 20.


Biological and clinical relevance of transcriptionally active human papillomavirus (HPV) infection in oropharynx squamous cell carcinoma.

Jung AC, Briolat J, Millon R, de Reyniès A, Rickman D, Thomas E, Abecassis J, Clavel C, Wasylyk B.

Int J Cancer. 2010 Apr 15;126(8):1882-1894. doi: 10.1002/ijc.24911.


Dissecting Distinct Roles of NEDDylation E1 Ligase Heterodimer APPBP1 and UBA3 Reveals Potential Evolution Process for Activation of Ubiquitin-related Pathways.

Malik-Chaudhry HK, Gaieb Z, Saavedra A, Reyes M, Kung R, Le F, Morikis D, Liao J.

Sci Rep. 2018 Jul 4;8(1):10108. doi: 10.1038/s41598-018-28214-2.


Amyloid precursor protein binding protein-1 modulates cell cycle progression in fetal neural stem cells.

Joo Y, Ha S, Hong BH, Kim Ja, Chang KA, Liew H, Kim S, Sun W, Kim JH, Chong YH, Suh YH, Kim HS.

PLoS One. 2010 Dec 2;5(12):e14203. doi: 10.1371/journal.pone.0014203.


The structure of the APPBP1-UBA3-NEDD8-ATP complex reveals the basis for selective ubiquitin-like protein activation by an E1.

Walden H, Podgorski MS, Huang DT, Miller DW, Howard RJ, Minor DL Jr, Holton JM, Schulman BA.

Mol Cell. 2003 Dec;12(6):1427-37.


Neddylation pathway is up-regulated in human intrahepatic cholangiocarcinoma and serves as a potential therapeutic target.

Gao Q, Yu GY, Shi JY, Li LH, Zhang WJ, Wang ZC, Yang LX, Duan M, Zhao H, Wang XY, Zhou J, Qiu SJ, Jeong LS, Jia LJ, Fan J.

Oncotarget. 2014 Sep 15;5(17):7820-32.


Structural dissection of a gating mechanism preventing misactivation of ubiquitin by NEDD8's E1.

Souphron J, Waddell MB, Paydar A, Tokgöz-Gromley Z, Roussel MF, Schulman BA.

Biochemistry. 2008 Aug 26;47(34):8961-9. doi: 10.1021/bi800604c. Epub 2008 Jul 25.


Basis for a ubiquitin-like protein thioester switch toggling E1-E2 affinity.

Huang DT, Hunt HW, Zhuang M, Ohi MD, Holton JM, Schulman BA.

Nature. 2007 Jan 25;445(7126):394-8. Epub 2007 Jan 14.


Insights into the ubiquitin transfer cascade from the structure of the activating enzyme for NEDD8.

Walden H, Podgorski MS, Schulman BA.

Nature. 2003 Mar 20;422(6929):330-4.


APP-BP1, a novel protein that binds to the carboxyl-terminal region of the amyloid precursor protein.

Chow N, Korenberg JR, Chen XN, Neve RL.

J Biol Chem. 1996 May 10;271(19):11339-46.


Conservation in the mechanism of Nedd8 activation by the human AppBp1-Uba3 heterodimer.

Bohnsack RN, Haas AL.

J Biol Chem. 2003 Jul 18;278(29):26823-30. Epub 2003 May 10.


A new NEDD8-ligating system for cullin-4A.

Osaka F, Kawasaki H, Aida N, Saeki M, Chiba T, Kawashima S, Tanaka K, Kato S.

Genes Dev. 1998 Aug 1;12(15):2263-8.


Neddylation requires glycyl-tRNA synthetase to protect activated E2.

Mo Z, Zhang Q, Liu Z, Lauer J, Shi Y, Sun L, Griffin PR, Yang XL.

Nat Struct Mol Biol. 2016 Aug;23(8):730-7. doi: 10.1038/nsmb.3250. Epub 2016 Jun 27.


TRIP12 functions as an E3 ubiquitin ligase of APP-BP1.

Park Y, Yoon SK, Yoon JB.

Biochem Biophys Res Commun. 2008 Sep 19;374(2):294-8. doi: 10.1016/j.bbrc.2008.07.019. Epub 2008 Jul 15.


Single-nucleotide polymorphisms in NAGNAG acceptors are highly predictive for variations of alternative splicing.

Hiller M, Huse K, Szafranski K, Jahn N, Hampe J, Schreiber S, Backofen R, Platzer M.

Am J Hum Genet. 2006 Feb;78(2):291-302. Epub 2005 Dec 22.


A unique E1-E2 interaction required for optimal conjugation of the ubiquitin-like protein NEDD8.

Huang DT, Miller DW, Mathew R, Cassell R, Holton JM, Roussel MF, Schulman BA.

Nat Struct Mol Biol. 2004 Oct;11(10):927-35. Epub 2004 Sep 7.

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