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RNA N6-methyladenosine methyltransferase-like 3 promotes liver cancer progression through YTHDF2-dependent posttranscriptional silencing of SOCS2.

Chen M, Wei L, Law CT, Tsang FH, Shen J, Cheng CL, Tsang LH, Ho DW, Chiu DK, Lee JM, Wong CC, Ng IO, Wong CM.

Hepatology. 2018 Jun;67(6):2254-2270. doi: 10.1002/hep.29683. Epub 2018 Apr 19.


A herpes simplex virus type 2-encoded microRNA promotes tumor cell metastasis by targeting suppressor of cytokine signaling 2 in lung cancer.

Wang X, Liu S, Zhou Z, Yan H, Xiao J.

Tumour Biol. 2017 May;39(5):1010428317701633. doi: 10.1177/1010428317701633.


SOCS2 polymorphisms are not associated with clinical and biochemical phenotypes in acromegalic patients.

Trarbach EB, Jorge AA, Duarte FH, Bronstein MD, Jallad RS.

Pituitary. 2017 Jun;20(3):319-324. doi: 10.1007/s11102-016-0779-1.


GLP-1 analogue recovers impaired insulin secretion from human islets treated with palmitate via down-regulation of SOCS2.

Chowdhury AI, Bergsten P.

Mol Cell Endocrinol. 2017 Jan 5;439:194-202. doi: 10.1016/j.mce.2016.08.034. Epub 2016 Aug 23.


The suppressor of cytokine signaling 2 (SOCS2) inhibits tumor metastasis in hepatocellular carcinoma.

Cui M, Sun J, Hou J, Fang T, Wang X, Ge C, Zhao F, Chen T, Xie H, Cui Y, Yao M, Li J, Li H.

Tumour Biol. 2016 Oct;37(10):13521-13531. Epub 2016 Jul 28.


Suppressor of Cytokine Signaling-2 (SOCS2) Regulates the Microglial Response and Improves Functional Outcome after Traumatic Brain Injury in Mice.

Basrai HS, Christie KJ, Turbic A, Bye N, Turnley AM.

PLoS One. 2016 Apr 12;11(4):e0153418. doi: 10.1371/journal.pone.0153418. eCollection 2016.


SOCS2: physiological and pathological functions.

Letellier E, Haan S.

Front Biosci (Elite Ed). 2016 Jan 1;8:189-204. Review.


MiR-101 inhibits cell growth and tumorigenesis of Helicobacter pylori related gastric cancer by repression of SOCS2.

Zhou X, Xia Y, Li L, Zhang G.

Cancer Biol Ther. 2015;16(1):160-9. doi: 10.4161/15384047.2014.987523.


Dopaminergic activity and behaviour in SOCS2 transgenic mice: Revealing a potential drug target for schizophrenia.

Ratnayake U, Basrai HS, Turnley AM, van den Buuse M.

Prog Neuropsychopharmacol Biol Psychiatry. 2015 Jan 2;56:247-53. doi: 10.1016/j.pnpbp.2014.09.009. Epub 2014 Oct 5.


Genetic predictors of long-term response to growth hormone (GH) therapy in children with GH deficiency and Turner syndrome: the influence of a SOCS2 polymorphism.

Braz AF, Costalonga EF, Trarbach EB, Scalco RC, Malaquias AC, Guerra-Junior G, Antonini SR, Mendonca BB, Arnhold IJ, Jorge AA.

J Clin Endocrinol Metab. 2014 Sep;99(9):E1808-13. doi: 10.1210/jc.2014-1744. Epub 2014 Jun 6.


High expression of suppressor of cytokine signaling-2 predicts poor outcome in pediatric acute myeloid leukemia: a report from the Children's Oncology Group.

Laszlo GS, Ries RE, Gudgeon CJ, Harrington KH, Alonzo TA, Gerbing RB, Raimondi SC, Hirsch BA, Gamis AS, Meshinchi S, Walter RB.

Leuk Lymphoma. 2014 Dec;55(12):2817-21. doi: 10.3109/10428194.2014.893305. Epub 2014 Mar 24.


SOCS2 correlates with malignancy and exerts growth-promoting effects in prostate cancer.

Hoefer J, Kern J, Ofer P, Eder IE, Schäfer G, Dietrich D, Kristiansen G, Geley S, Rainer J, Gunsilius E, Klocker H, Culig Z, Puhr M.

Endocr Relat Cancer. 2014 Jan 30;21(2):175-87. doi: 10.1530/ERC-13-0446. Print 2014 Apr.


Saponin inhibits hepatitis C virus propagation by up-regulating suppressor of cytokine signaling 2.

Lee J, Lim S, Kang SM, Min S, Son K, Lee HS, Park EM, Ngo HT, Tran HT, Lim YS, Hwang SB.

PLoS One. 2012;7(6):e39366. doi: 10.1371/journal.pone.0039366. Epub 2012 Jun 20.


LPS regulates SOCS2 transcription in a type I interferon dependent autocrine-paracrine loop.

Hu J, Lou D, Carow B, Winerdal ME, Rottenberg M, Wikström AC, Norstedt G, Winqvist O.

PLoS One. 2012;7(1):e30166. doi: 10.1371/journal.pone.0030166. Epub 2012 Jan 23.


Changes in the expression of suppressor of cytokine signalling (SOCS) 2 in the colonic mucosa of acromegalic patients are associated with hyperplastic polyps.

Bogazzi F, Ultimieri F, Raggi F, Russo D, Costa A, Marciano E, Bartalena L, Martino E.

Clin Endocrinol (Oxf). 2009 Jun;70(6):898-906. doi: 10.1111/j.1365-2265.2008.03431.x. Epub 2008 Sep 24.


Overexpression of SOCS-2 in advanced stages of chronic myeloid leukemia: possible inadequacy of a negative feedback mechanism.

Schultheis B, Carapeti-Marootian M, Hochhaus A, Weisser A, Goldman JM, Melo JV.

Blood. 2002 Mar 1;99(5):1766-75.


miR-196b is a prognostic factor of human laryngeal squamous cell carcinoma and promotes tumor progression by targeting SOCS2.

Zhao X, Zhang W, Ji W.

Biochem Biophys Res Commun. 2018 Jun 22;501(2):584-592. doi: 10.1016/j.bbrc.2018.05.052.


Alterations in the p53-SOCS2 axis contribute to tumor growth in colon cancer.

Kim JH, Lee MJ, Yu GR, Kim SW, Jang KY, Yu HC, Cho BH, Kim DG.

Exp Mol Med. 2018 Apr 6;50(4):3. doi: 10.1038/s12276-017-0001-1.


A growth hormone receptor SNP promotes lung cancer by impairment of SOCS2-mediated degradation.

Chhabra Y, Wong HY, Nikolajsen LF, Steinocher H, Papadopulos A, Tunny KA, Meunier FA, Smith AG, Kragelund BB, Brooks AJ, Waters MJ.

Oncogene. 2018 Jan 25;37(4):489-501. doi: 10.1038/onc.2017.352. Epub 2017 Oct 2.


The ubiquitin ligase Cullin5SOCS2 regulates NDR1/STK38 stability and NF-κB transactivation.

Paul I, Batth TS, Iglesias-Gato D, Al-Araimi A, Al-Haddabi I, Alkharusi A, Norstedt G, Olsen JV, Zadjali F, Flores-Morales A.

Sci Rep. 2017 Feb 20;7:42800. doi: 10.1038/srep42800.

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