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Items: 1 to 20 of 58

1.

CDK12 regulates alternative last exon mRNA splicing and promotes breast cancer cell invasion.

Tien JF, Mazloomian A, Cheng SG, Hughes CS, Chow CCT, Canapi LT, Oloumi A, Trigo-Gonzalez G, Bashashati A, Xu J, Chang VC, Shah SP, Aparicio S, Morin GB.

Nucleic Acids Res. 2017 Jun 20;45(11):6698-6716. doi: 10.1093/nar/gkx187.

2.

Ovarian Cancers Harboring Inactivating Mutations in CDK12 Display a Distinct Genomic Instability Pattern Characterized by Large Tandem Duplications.

Popova T, Manié E, Boeva V, Battistella A, Goundiam O, Smith NK, Mueller CR, Raynal V, Mariani O, Sastre-Garau X, Stern MH.

Cancer Res. 2016 Apr 1;76(7):1882-91. doi: 10.1158/0008-5472.CAN-15-2128. Epub 2016 Jan 19.

3.

Expression, purification, and identification of associated proteins of the full-length hCDK12/CyclinK complex.

Bartkowiak B, Greenleaf AL.

J Biol Chem. 2015 Jan 16;290(3):1786-95. doi: 10.1074/jbc.M114.612226. Epub 2014 Nov 26.

4.
5.

Genome-wide profiling of genetic synthetic lethality identifies CDK12 as a novel determinant of PARP1/2 inhibitor sensitivity.

Bajrami I, Frankum JR, Konde A, Miller RE, Rehman FL, Brough R, Campbell J, Sims D, Rafiq R, Hooper S, Chen L, Kozarewa I, Assiotis I, Fenwick K, Natrajan R, Lord CJ, Ashworth A.

Cancer Res. 2014 Jan 1;74(1):287-97. doi: 10.1158/0008-5472.CAN-13-2541. Epub 2013 Nov 15.

6.

Cyclin K regulates prereplicative complex assembly to promote mammalian cell proliferation.

Lei T, Zhang P, Zhang X, Xiao X, Zhang J, Qiu T, Dai Q, Zhang Y, Min L, Li Q, Yin R, Ding P, Li N, Qu Y, Mu D, Qin J, Zhu X, Xiao ZX, Li Q.

Nat Commun. 2018 May 14;9(1):1876. doi: 10.1038/s41467-018-04258-w.

7.

Structures of the CDK12/CycK complex with AMP-PNP reveal a flexible C-terminal kinase extension important for ATP binding.

Dixon-Clarke SE, Elkins JM, Cheng SW, Morin GB, Bullock AN.

Sci Rep. 2015 Nov 24;5:17122. doi: 10.1038/srep17122.

8.

Ovarian carcinoma CDK12 mutations misregulate expression of DNA repair genes via deficient formation and function of the Cdk12/CycK complex.

Ekumi KM, Paculova H, Lenasi T, Pospichalova V, Bösken CA, Rybarikova J, Bryja V, Geyer M, Blazek D, Barboric M.

Nucleic Acids Res. 2015 Mar 11;43(5):2575-89. doi: 10.1093/nar/gkv101. Epub 2015 Feb 20.

9.

Characterization of human cyclin-dependent kinase 12 (CDK12) and CDK13 complexes in C-terminal domain phosphorylation, gene transcription, and RNA processing.

Liang K, Gao X, Gilmore JM, Florens L, Washburn MP, Smith E, Shilatifard A.

Mol Cell Biol. 2015 Mar;35(6):928-38. doi: 10.1128/MCB.01426-14. Epub 2015 Jan 5.

10.

Cyclin-dependent kinase 12 increases 3' end processing of growth factor-induced c-FOS transcripts.

Eifler TT, Shao W, Bartholomeeusen K, Fujinaga K, Jäger S, Johnson JR, Luo Z, Krogan NJ, Peterlin BM.

Mol Cell Biol. 2015 Jan;35(2):468-78. doi: 10.1128/MCB.01157-14. Epub 2014 Nov 10.

11.

CRK7 modifies the MAPK pathway and influences the response to endocrine therapy.

Iorns E, Martens-de Kemp SR, Lord CJ, Ashworth A.

Carcinogenesis. 2009 Oct;30(10):1696-701. doi: 10.1093/carcin/bgp187. Epub 2009 Aug 3.

PMID:
19651820
12.

Arrest of cell cycle by amida which is phosphorylated by Cdc2 kinase.

Gan Y, Taira E, Irie Y, Fujimoto T, Miki N.

Mol Cell Biochem. 2003 Apr;246(1-2):179-85.

PMID:
12841360
13.

BRCA1 or CDK12 loss sensitizes cells to CHK1 inhibitors.

Paculová H, Kramara J, Šimečková Š, Fedr R, Souček K, Hylse O, Paruch K, Svoboda M, Mistrík M, Kohoutek J.

Tumour Biol. 2017 Oct;39(10):1010428317727479. doi: 10.1177/1010428317727479.

PMID:
29025359
14.

Interaction of cyclin-dependent kinase 12/CrkRS with cyclin K1 is required for the phosphorylation of the C-terminal domain of RNA polymerase II.

Cheng SW, Kuzyk MA, Moradian A, Ichu TA, Chang VC, Tien JF, Vollett SE, Griffith M, Marra MA, Morin GB.

Mol Cell Biol. 2012 Nov;32(22):4691-704. doi: 10.1128/MCB.06267-11. Epub 2012 Sep 17.

15.

CrkRS: a novel conserved Cdc2-related protein kinase that colocalises with SC35 speckles.

Ko TK, Kelly E, Pines J.

J Cell Sci. 2001 Jul;114(Pt 14):2591-603.

16.

The Cyclin K/Cdk12 complex maintains genomic stability via regulation of expression of DNA damage response genes.

Blazek D, Kohoutek J, Bartholomeeusen K, Johansen E, Hulinkova P, Luo Z, Cimermancic P, Ule J, Peterlin BM.

Genes Dev. 2011 Oct 15;25(20):2158-72. doi: 10.1101/gad.16962311.

17.

Cyclin-dependent kinases: a family portrait.

Malumbres M, Harlow E, Hunt T, Hunter T, Lahti JM, Manning G, Morgan DO, Tsai LH, Wolgemuth DJ.

Nat Cell Biol. 2009 Nov;11(11):1275-6. doi: 10.1038/ncb1109-1275. No abstract available.

18.

Cyclin K-containing kinase complexes maintain self-renewal in murine embryonic stem cells.

Dai Q, Lei T, Zhao C, Zhong J, Tang YZ, Chen B, Yang J, Li C, Wang S, Song X, Li L, Li Q.

J Biol Chem. 2012 Jul 20;287(30):25344-52. doi: 10.1074/jbc.M111.321760. Epub 2012 Apr 30.

19.

CDK12 is a transcription elongation-associated CTD kinase, the metazoan ortholog of yeast Ctk1.

Bartkowiak B, Liu P, Phatnani HP, Fuda NJ, Cooper JJ, Price DH, Adelman K, Lis JT, Greenleaf AL.

Genes Dev. 2010 Oct 15;24(20):2303-16. doi: 10.1101/gad.1968210.

20.

LASP-1: a nuclear hub for the UHRF1-DNMT1-G9a-Snail1 complex.

Duvall-Noelle N, Karwandyar A, Richmond A, Raman D.

Oncogene. 2016 Mar 3;35(9):1122-33. doi: 10.1038/onc.2015.166. Epub 2015 May 18.

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