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Screening of GLE1 mutations in Chinese amyotrophic lateral sclerosis patients.

Zhang K, Liu Q, Shen D, Tai H, Fu H, Liu S, Chen J, Li X, Liu M, Zhang X, Cui L.

Neurobiol Aging. 2018 Jun;66:178.e9-178.e11. doi: 10.1016/j.neurobiolaging.2017.12.029. Epub 2018 Jan 5.


Survival beyond the perinatal period expands the phenotypes caused by mutations in GLE1.

Said E, Chong JX, Hempel M, Denecke J, Soler P, Strom T, Nickerson DA, Kubisch C; University of Washington Center for Mendelian Genomics, Bamshad MJ, Lessel D.

Am J Med Genet A. 2017 Nov;173(11):3098-3103. doi: 10.1002/ajmg.a.38406. Epub 2017 Sep 8.


A homozygous I684T in GLE1 as a novel cause of arthrogryposis and motor neuron loss.

Paakkola T, Vuopala K, Kokkonen H, Ignatius J, Valkama M, Moilanen JS, Fahiminiya S, Majewski J, Hinttala R, Uusimaa J.

Clin Genet. 2018 Jan;93(1):173-177. doi: 10.1111/cge.13086. Epub 2017 Nov 24.


Expansion of the GLE1-associated arthrogryposis multiplex congenita clinical spectrum.

Smith C, Parboosingh JS, Boycott KM, Bönnemann CG, Mah JK; Care4Rare Canada Consortium, Lamont RE, Micheil Innes A, Bernier FP.

Clin Genet. 2017 Mar;91(3):426-430. doi: 10.1111/cge.12876. Epub 2017 Jan 30.


An amyotrophic lateral sclerosis-linked mutation in GLE1 alters the cellular pool of human Gle1 functional isoforms.

Aditi, Glass L, Dawson TR, Wente SR.

Adv Biol Regul. 2016 Sep;62:25-36. doi: 10.1016/j.jbior.2015.11.001. Epub 2015 Nov 11.


Cytoplasmic hGle1A regulates stress granules by modulation of translation.

Aditi, Folkmann AW, Wente SR.

Mol Biol Cell. 2015 Apr 15;26(8):1476-90. doi: 10.1091/mbc.E14-11-1523. Epub 2015 Feb 18.


Insights into mRNA export-linked molecular mechanisms of human disease through a Gle1 structure-function analysis.

Folkmann AW, Dawson TR, Wente SR.

Adv Biol Regul. 2014 Jan;54:74-91. doi: 10.1016/j.jbior.2013.10.002. Epub 2013 Nov 13. Review.


Mutations in mRNA export mediator GLE1 result in a fetal motoneuron disease.

Nousiainen HO, Kestilä M, Pakkasjärvi N, Honkala H, Kuure S, Tallila J, Vuopala K, Ignatius J, Herva R, Peltonen L.

Nat Genet. 2008 Feb;40(2):155-7. doi: 10.1038/ng.2007.65. Epub 2008 Jan 20.


An essential role for hGle1 nucleocytoplasmic shuttling in mRNA export.

Kendirgi F, Barry DM, Griffis ER, Powers MA, Wente SR.

J Cell Biol. 2003 Mar 31;160(7):1029-40.


Assignment of the disease locus for lethal congenital contracture syndrome to a restricted region of chromosome 9q34, by genome scan using five affected individuals.

Mäkelä-Bengs P, Järvinen N, Vuopala K, Suomalainen A, Ignatius J, Sipilä M, Herva R, Palotie A, Peltonen L.

Am J Hum Genet. 1998 Aug;63(2):506-16.


The human homologue of Saccharomyces cerevisiae Gle1p is required for poly(A)+ RNA export.

Watkins JL, Murphy R, Emtage JL, Wente SR.

Proc Natl Acad Sci U S A. 1998 Jun 9;95(12):6779-84.


Deleterious mutations in the essential mRNA metabolism factor, hGle1, in amyotrophic lateral sclerosis.

Kaneb HM, Folkmann AW, Belzil VV, Jao LE, Leblond CS, Girard SL, Daoud H, Noreau A, Rochefort D, Hince P, Szuto A, Levert A, Vidal S, André-Guimont C, Camu W, Bouchard JP, Dupré N, Rouleau GA, Wente SR, Dion PA.

Hum Mol Genet. 2015 Mar 1;24(5):1363-73. doi: 10.1093/hmg/ddu545. Epub 2014 Oct 24.


Dbp5, Gle1-IP6 and Nup159: a working model for mRNP export.

Folkmann AW, Noble KN, Cole CN, Wente SR.

Nucleus. 2011 Nov-Dec;2(6):540-8. doi: 10.4161/nucl.2.6.17881. Epub 2011 Nov 1. Review.


Interaction between the shuttling mRNA export factor Gle1 and the nucleoporin hCG1: a conserved mechanism in the export of Hsp70 mRNA.

Kendirgi F, Rexer DJ, Alcázar-Román AR, Onishko HM, Wente SR.

Mol Biol Cell. 2005 Sep;16(9):4304-15. Epub 2005 Jul 6.


Depletion of mRNA export regulator DBP5/DDX19, GLE1 or IPPK that is a key enzyme for the production of IP6, resulting in differentially altered cytoplasmic mRNA expression and specific cell defect.

Okamura M, Yamanaka Y, Shigemoto M, Kitadani Y, Kobayashi Y, Kambe T, Nagao M, Kobayashi I, Okumura K, Masuda S.

PLoS One. 2018 May 10;13(5):e0197165. doi: 10.1371/journal.pone.0197165. eCollection 2018.


Restoration of miR-127-3p and miR-376a-3p counteracts the neoplastic phenotype of giant cell tumor of bone derived stromal cells by targeting COA1, GLE1 and PDIA6.

Fellenberg J, Sähr H, Kunz P, Zhao Z, Liu L, Tichy D, Herr I.

Cancer Lett. 2016 Feb 1;371(1):134-41. doi: 10.1016/j.canlet.2015.10.039. Epub 2015 Nov 30.


The mRNA export factor human Gle1 interacts with the nuclear pore complex protein Nup155.

Rayala HJ, Kendirgi F, Barry DM, Majerus PW, Wente SR.

Mol Cell Proteomics. 2004 Feb;3(2):145-55. Epub 2003 Nov 25.


A zebrafish model of lethal congenital contracture syndrome 1 reveals Gle1 function in spinal neural precursor survival and motor axon arborization.

Jao LE, Appel B, Wente SR.

Development. 2012 Apr;139(7):1316-26. doi: 10.1242/dev.074344. Epub 2012 Feb 22.


Gle1 functions during mRNA export in an oligomeric complex that is altered in human disease.

Folkmann AW, Collier SE, Zhan X, Aditi, Ohi MD, Wente SR.

Cell. 2013 Oct 24;155(3):582-93. doi: 10.1016/j.cell.2013.09.023. Epub 2013 Oct 24.


The mRNA export factor Gle1 and inositol hexakisphosphate regulate distinct stages of translation.

Bolger TA, Folkmann AW, Tran EJ, Wente SR.

Cell. 2008 Aug 22;134(4):624-33. doi: 10.1016/j.cell.2008.06.027.

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