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Crk Adaptor Proteins Regulate NK Cell Expansion and Differentiation during Mouse Cytomegalovirus Infection.

Nabekura T, Chen Z, Schroeder C, Park T, Vivier E, Lanier LL, Liu D.

J Immunol. 2018 May 15;200(10):3420-3428. doi: 10.4049/jimmunol.1701639. Epub 2018 Apr 4.


CrkII transgene induces atypical mammary gland development and tumorigenesis.

Fathers KE, Rodrigues S, Zuo D, Murthy IV, Hallett M, Cardiff R, Park M.

Am J Pathol. 2010 Jan;176(1):446-60. doi: 10.2353/ajpath.2010.090383. Epub 2009 Dec 11.


Distinct roles for Crk adaptor isoforms in actin reorganization induced by extracellular signals.

Antoku S, Mayer BJ.

J Cell Sci. 2009 Nov 15;122(Pt 22):4228-38. doi: 10.1242/jcs.054627. Epub 2009 Oct 27.


CrkIII: a novel and biologically distinct member of the Crk family of adaptor proteins.

Prosser S, Sorokina E, Pratt P, Sorokin A.

Oncogene. 2003 Jul 31;22(31):4799-806.


Mutant mice lacking Crk-II caused by the gene trap insertional mutagenesis: Crk-II is not essential for embryonic development.

Imaizumi T, Araki K, Miura K, Araki M, Suzuki M, Terasaki H, Yamamura K.

Biochem Biophys Res Commun. 1999 Dec 20;266(2):569-74.


Targeted expression of an oncogenic adaptor protein v-Crk potentiates axonal growth in dorsal root ganglia and motor neurons in vivo.

Weinstein DE, Dobrenis K, Birge RB.

Brain Res Dev Brain Res. 1999 Aug 5;116(1):29-39.


Exploiting the basis of proline recognition by SH3 and WW domains: design of N-substituted inhibitors.

Nguyen JT, Turck CW, Cohen FE, Zuckermann RN, Lim WA.

Science. 1998 Dec 11;282(5396):2088-92.


The C-terminal SH3 domain of the mouse c-Crk protein negatively regulates tyrosine-phosphorylation of Crk associated p130 in rat 3Y1 cells.

Ogawa S, Toyoshima H, Kozutsumi H, Hagiwara K, Sakai R, Tanaka T, Hirano N, Mano H, Yazaki Y, Hirai H.

Oncogene. 1994 Jun;9(6):1669-78.


Structural basis for the specific interaction of lysine-containing proline-rich peptides with the N-terminal SH3 domain of c-Crk.

Wu X, Knudsen B, Feller SM, Zheng J, Sali A, Cowburn D, Hanafusa H, Kuriyan J.

Structure. 1995 Feb 15;3(2):215-26.


Crk Tyrosine Phosphorylation Regulates PDGF-BB-inducible Src Activation and Breast Tumorigenicity and Metastasis.

Kumar S, Lu B, Davra V, Hornbeck P, Machida K, Birge RB.

Mol Cancer Res. 2018 Jan;16(1):173-183. doi: 10.1158/1541-7786.MCR-17-0242. Epub 2017 Oct 3.


Fibroblast Growth Requires CT10 Regulator of Kinase (Crk) and Crk-like (CrkL).

Park T, Koptyra M, Curran T.

J Biol Chem. 2016 Dec 16;291(51):26273-26290. Epub 2016 Nov 2.


Crk and CrkL are required for cell transformation by v-fos and v-ras.

Koptyra M, Park TJ, Curran T.

Mol Carcinog. 2016 Jan;55(1):97-104. doi: 10.1002/mc.22262. Epub 2015 Jan 3.


Phosphorylation of Dok1 by Abl family kinases inhibits CrkI transforming activity.

Ng KY, Yin T, Machida K, Wu YI, Mayer BJ.

Oncogene. 2015 May 14;34(20):2650-9. doi: 10.1038/onc.2014.210. Epub 2014 Jul 21.


Essential roles of Crk and CrkL in fibroblast structure and motility.

Park TJ, Curran T.

Oncogene. 2014 Oct 23;33(43):5121-32. doi: 10.1038/onc.2013.453. Epub 2013 Oct 28.


Interaction of crk with Myosin-1c participates in fibronectin-induced cell spreading.

Oh H, Kim H, Shin B, Lee KH, Yeo MG, Song WK.

Int J Biol Sci. 2013 Aug 15;9(8):778-91. doi: 10.7150/ijbs.6459. eCollection 2013.


Crk1/2-dependent signaling is necessary for podocyte foot process spreading in mouse models of glomerular disease.

George B, Verma R, Soofi AA, Garg P, Zhang J, Park TJ, Giardino L, Ryzhova L, Johnstone DB, Wong H, Nihalani D, Salant DJ, Hanks SK, Curran T, Rastaldi MP, Holzman LB.

J Clin Invest. 2012 Feb;122(2):674-92. doi: 10.1172/JCI60070. Epub 2012 Jan 17.


A genetically selective inhibitor demonstrates a function for the kinase Zap70 in regulatory T cells independent of its catalytic activity.

Au-Yeung BB, Levin SE, Zhang C, Hsu LY, Cheng DA, Killeen N, Shokat KM, Weiss A.

Nat Immunol. 2010 Dec;11(12):1085-92. doi: 10.1038/ni.1955. Epub 2010 Oct 31.


Proteins that bind the Src homology 3 domain of CrkI have distinct roles in Crk transformation.

Zheng J, Machida K, Antoku S, Ng KY, Claffey KP, Mayer BJ.

Oncogene. 2010 Dec 2;29(48):6378-89. doi: 10.1038/onc.2010.369. Epub 2010 Aug 23.


Crk and Crk-like play essential overlapping roles downstream of disabled-1 in the Reelin pathway.

Park TJ, Curran T.

J Neurosci. 2008 Dec 10;28(50):13551-62. doi: 10.1523/JNEUROSCI.4323-08.2008.

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