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Items: 20

1.

Developing therapeutic approaches to tau, selected kinases, and related neuronal protein targets.

Lee VM, Brunden KR, Hutton M, Trojanowski JQ.

Cold Spring Harb Perspect Med. 2011 Sep;1(1):a006437. doi: 10.1101/cshperspect.a006437. Review.

2.

Epigenetic characterization of the FMR1 gene and aberrant neurodevelopment in human induced pluripotent stem cell models of fragile X syndrome.

Sheridan SD, Theriault KM, Reis SA, Zhou F, Madison JM, Daheron L, Loring JF, Haggarty SJ.

PLoS One. 2011;6(10):e26203. doi: 10.1371/journal.pone.0026203. Epub 2011 Oct 12.

3.

Disrupted in schizophrenia 1 regulates neuronal progenitor proliferation via modulation of GSK3beta/beta-catenin signaling.

Mao Y, Ge X, Frank CL, Madison JM, Koehler AN, Doud MK, Tassa C, Berry EM, Soda T, Singh KK, Biechele T, Petryshen TL, Moon RT, Haggarty SJ, Tsai LH.

Cell. 2009 Mar 20;136(6):1017-31. doi: 10.1016/j.cell.2008.12.044.

4.

Distinct roles of GSK-3alpha and GSK-3beta phosphorylation in the heart under pressure overload.

Matsuda T, Zhai P, Maejima Y, Hong C, Gao S, Tian B, Goto K, Takagi H, Tamamori-Adachi M, Kitajima S, Sadoshima J.

Proc Natl Acad Sci U S A. 2008 Dec 30;105(52):20900-5. doi: 10.1073/pnas.0808315106. Epub 2008 Dec 23.

5.

Assaying beta-catenin/TCF transcription with beta-catenin/TCF transcription-based reporter constructs.

Biechele TL, Moon RT.

Methods Mol Biol. 2008;468:99-110. doi: 10.1007/978-1-59745-249-6_8.

PMID:
19099249
6.

The GSK3 hypothesis of Alzheimer's disease.

Hooper C, Killick R, Lovestone S.

J Neurochem. 2008 Mar;104(6):1433-9. Epub 2007 Dec 18. Review.

7.

Lithium regulates adult hippocampal progenitor development through canonical Wnt pathway activation.

Wexler EM, Geschwind DH, Palmer TD.

Mol Psychiatry. 2008 Mar;13(3):285-92. Epub 2007 Oct 30.

PMID:
17968353
8.

Glycogen synthase kinase 3: a key regulator of cellular fate.

Forde JE, Dale TC.

Cell Mol Life Sci. 2007 Aug;64(15):1930-44. Review.

PMID:
17530463
9.

The Akt-GSK-3 signaling cascade in the actions of dopamine.

Beaulieu JM, Gainetdinov RR, Caron MG.

Trends Pharmacol Sci. 2007 Apr;28(4):166-72. Epub 2007 Mar 8. Review.

PMID:
17349698
10.

Targeting glycogen synthase kinase-3 in the CNS: implications for the development of new treatments for mood disorders.

Gould TD, Picchini AM, Einat H, Manji HK.

Curr Drug Targets. 2006 Nov;7(11):1399-409. Review.

PMID:
17100580
11.

Structural basis for the synthesis of indirubins as potent and selective inhibitors of glycogen synthase kinase-3 and cyclin-dependent kinases.

Polychronopoulos P, Magiatis P, Skaltsounis AL, Myrianthopoulos V, Mikros E, Tarricone A, Musacchio A, Roe SM, Pearl L, Leost M, Greengard P, Meijer L.

J Med Chem. 2004 Feb 12;47(4):935-46.

PMID:
14761195
12.

GSK-3-selective inhibitors derived from Tyrian purple indirubins.

Meijer L, Skaltsounis AL, Magiatis P, Polychronopoulos P, Knockaert M, Leost M, Ryan XP, Vonica CA, Brivanlou A, Dajani R, Crovace C, Tarricone C, Musacchio A, Roe SM, Pearl L, Greengard P.

Chem Biol. 2003 Dec;10(12):1255-66.

13.

Physiological roles of glycogen synthase kinase-3: potential as a therapeutic target for diabetes and other disorders.

Woodgett JR.

Curr Drug Targets Immune Endocr Metabol Disord. 2003 Dec;3(4):281-90. Review.

14.

GSK-3alpha regulates production of Alzheimer's disease amyloid-beta peptides.

Phiel CJ, Wilson CA, Lee VM, Klein PS.

Nature. 2003 May 22;423(6938):435-9.

PMID:
12761548
15.

The specificities of protein kinase inhibitors: an update.

Bain J, McLauchlan H, Elliott M, Cohen P.

Biochem J. 2003 Apr 1;371(Pt 1):199-204.

16.

Role of glycogen synthase kinase-3 in cancer: regulation by Wnts and other signaling pathways.

Manoukian AS, Woodgett JR.

Adv Cancer Res. 2002;84:203-29. Review.

PMID:
11883528
17.

Indirubins inhibit glycogen synthase kinase-3 beta and CDK5/p25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer's disease. A property common to most cyclin-dependent kinase inhibitors?

Leclerc S, Garnier M, Hoessel R, Marko D, Bibb JA, Snyder GL, Greengard P, Biernat J, Wu YZ, Mandelkow EM, Eisenbrand G, Meijer L.

J Biol Chem. 2001 Jan 5;276(1):251-60.

18.

Paullones are potent inhibitors of glycogen synthase kinase-3beta and cyclin-dependent kinase 5/p25.

Leost M, Schultz C, Link A, Wu YZ, Biernat J, Mandelkow EM, Bibb JA, Snyder GL, Greengard P, Zaharevitz DW, Gussio R, Senderowicz AM, Sausville EA, Kunick C, Meijer L.

Eur J Biochem. 2000 Oct;267(19):5983-94.

19.

Enhancement of hippocampal neurogenesis by lithium.

Chen G, Rajkowska G, Du F, Seraji-Bozorgzad N, Manji HK.

J Neurochem. 2000 Oct;75(4):1729-34.

20.

Synthesis and application of functionally diverse 2,6,9-trisubstituted purine libraries as CDK inhibitors.

Chang YT, Gray NS, Rosania GR, Sutherlin DP, Kwon S, Norman TC, Sarohia R, Leost M, Meijer L, Schultz PG.

Chem Biol. 1999 Jun;6(6):361-75.

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