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Items: 1 to 20 of 2870

1.

Chimeric Antigen Receptor T Cells in Refractory B-Cell Lymphomas.

Schuster SJ, Svoboda J, Chong EA, Nasta SD, Mato AR, Anak Ö, Brogdon JL, Pruteanu-Malinici I, Bhoj V, Landsburg D, Wasik M, Levine BL, Lacey SF, Melenhorst JJ, Porter DL, June CH.

N Engl J Med. 2017 Dec 10. doi: 10.1056/NEJMoa1708566. [Epub ahead of print]

PMID:
29226764
2.

Improving average ranking precision in user searches for biomedical research datasets.

Teodoro D, Mottin L, Gobeill J, Gaudinat A, Vachon T, Ruch P.

Database (Oxford). 2017 Jan 1;2017. doi: 10.1093/database/bax083.

3.

Drug development for neurodevelopmental disorders: lessons learned from fragile X syndrome.

Berry-Kravis EM, Lindemann L, Jønch AE, Apostol G, Bear MF, Carpenter RL, Crawley JN, Curie A, Des Portes V, Hossain F, Gasparini F, Gomez-Mancilla B, Hessl D, Loth E, Scharf SH, Wang PP, Von Raison F, Hagerman R, Spooren W, Jacquemont S.

Nat Rev Drug Discov. 2017 Dec 8. doi: 10.1038/nrd.2017.221. [Epub ahead of print] Review.

PMID:
29217836
4.

A comparative transcriptomic analysis of replicating and dormant liver stages of the relapsing malaria parasite Plasmodium Cynomolgi.

Voorberg-van der Wel A, Roma G, Gupta DK, Schuierer S, Nigsch F, Carbone W, Zeeman AM, Lee BH, Hofman SO, Faber BW, Knehr J, Pasini E, Kinzel B, Bifani P, Bonamy GMC, Bouwmeester T, Kocken CHM, Diagana TT.

Elife. 2017 Dec 7;6. pii: e29605. doi: 10.7554/eLife.29605. [Epub ahead of print]

5.

Alterations in the in vitro and in vivo regulation of muscle regeneration in healthy ageing and the influence of sarcopenia.

Brzeszczyńska J, Meyer A, McGregor R, Schilb A, Degen S, Tadini V, Johns N, Langen R, Schols A, Glass DJ, Roubenoff R, Ross JA, Fearon KCH, Greig CA, Jacobi C.

J Cachexia Sarcopenia Muscle. 2017 Dec 6. doi: 10.1002/jcsm.12252. [Epub ahead of print]

6.

Targeting multiple nodes of MLL complexes to improve leukemia therapy.

Dafflon C, Tiedt R, Schwaller J.

Oncotarget. 2017 Oct 7;8(53):90614-90615. doi: 10.18632/oncotarget.21598. eCollection 2017 Oct 31. No abstract available.

7.

CRISPR-Cas9 screen reveals a MYCN-amplified neuroblastoma dependency on EZH2.

Chen L, Alexe G, Dharia NV, Ross L, Iniguez AB, Conway AS, Wang EJ, Veschi V, Lam N, Qi J, Gustafson WC, Nasholm N, Vazquez F, Weir BA, Cowley GS, Ali LD, Pantel S, Jiang G, Harrington WF, Lee Y, Goodale A, Lubonja R, Krill-Burger JM, Meyers RM, Tsherniak A, Root DE, Bradner JE, Golub TR, Roberts CW, Hahn WC, Weiss WA, Thiele CJ, Stegmaier K.

J Clin Invest. 2017 Dec 4. pii: 90793. doi: 10.1172/JCI90793. [Epub ahead of print]

8.

The Hierarchy of Proinflammatory Cytokines in Ocular Inflammation.

Da Cunha AP, Zhang Q, Prentiss M, Wu XQ, Kainz V, Xu YY, Vrouvlianis J, Li H, Rangaswamy N, Leehy B, McGee TL, Bell CL, Bigelow CE, Kansara V, Medley Q, Huang Q, Wu HY.

Curr Eye Res. 2017 Dec 4:1-13. doi: 10.1080/02713683.2017.1410180. [Epub ahead of print]

PMID:
29199855
9.

Phase II study of buparlisib (BKM120) and trastuzumab in patients with HER2+ locally advanced or metastatic breast cancer resistant to trastuzumab-based therapy.

Pistilli B, Pluard T, Urruticoechea A, Farci D, Kong A, Bachelot T, Chan S, Han HS, Jerusalem G, Urban P, Robinson D, Mouhaër SL, Tomaso ED, Massacesi C, Saura C.

Breast Cancer Res Treat. 2017 Dec 2. doi: 10.1007/s10549-017-4596-7. [Epub ahead of print]

PMID:
29198055
10.

Synthetic transcription elongation factors license transcription across repressive chromatin.

Erwin GS, Grieshop MP, Ali A, Qi J, Lawlor M, Kumar D, Ahmad I, McNally A, Teider N, Worringer K, Sivasankaran R, Syed DN, Eguchi A, Ashraf M, Jeffery J, Xu M, Park PMC, Mukhtar H, Srivastava AK, Faruq M, Bradner JE, Ansari AZ.

Science. 2017 Nov 30. pii: eaan6414. doi: 10.1126/science.aan6414. [Epub ahead of print]

PMID:
29192133
11.

High-Confidence Protein-Ligand Complex Modeling by NMR-Guided Docking Enables Early Hit Optimization.

Proudfoot A, Bussiere DE, Lingel A.

J Am Chem Soc. 2017 Nov 30. doi: 10.1021/jacs.7b07171. [Epub ahead of print]

PMID:
29190085
12.

Midostaurin, a Natural Product-Derived Kinase Inhibitor Recently Approved for the Treatment of Hematological MalignanciesPublished as part of the Biochemistry series "Biochemistry to Bedside".

Manley PW, Weisberg E, Sattler M, Griffin JD.

Biochemistry. 2017 Nov 30. doi: 10.1021/acs.biochem.7b01126. [Epub ahead of print] No abstract available.

PMID:
29188995
13.

Synthesis of 4,5-Diazaspiro[2.3]hexanes and 1,2-Diazaspiro[3.3]heptanes as Hexahydropyridazine Analogues.

Pancholi AK, Iacobini GP, Clarkson GJ, Porter DW, Shipman M.

J Org Chem. 2017 Dec 11. doi: 10.1021/acs.joc.7b02622. [Epub ahead of print]

PMID:
29183129
14.

Pharmacokinetics of CYP2C9, CYP2C19, and CYP2D6 substrates in healthy Chinese and European subjects.

Lu S, Nand RA, Yang JS, Chen G, Gross AS.

Eur J Clin Pharmacol. 2017 Nov 27. doi: 10.1007/s00228-017-2375-3. [Epub ahead of print]

PMID:
29181698
15.

Vps34 PI 3-kinase inactivation enhances insulin sensitivity through reprogramming of mitochondrial metabolism.

Bilanges B, Alliouachene S, Pearce W, Morelli D, Szabadkai G, Chung YL, Chicanne G, Valet C, Hill JM, Voshol PJ, Collinson L, Peddie C, Ali K, Ghazaly E, Rajeeve V, Trichas G, Srinivas S, Chaussade C, Salamon RS, Backer JM, Scudamore CL, Whitehead MA, Keaney EP, Murphy LO, Semple RK, Payrastre B, Tooze SA, Vanhaesebroeck B.

Nat Commun. 2017 Nov 27;8(1):1804. doi: 10.1038/s41467-017-01969-4.

16.

Impact of Coronary Computed Tomography Angiography Findings on Initiation of Cardioprotective Medications.

Chang AM, Litt HI, Snyder BS, Gatsonis C, Greco EM, Miller CD, Singh H, O'Conor KJ, Hollander JE.

Circulation. 2017 Nov 28;136(22):2195-2197. doi: 10.1161/CIRCULATIONAHA.117.029994. No abstract available.

PMID:
29180497
17.

Inhibition of group-I metabotropic glutamate receptors protects against prion toxicity.

Goniotaki D, Lakkaraju AKK, Shrivastava AN, Bakirci P, Sorce S, Senatore A, Marpakwar R, Hornemann S, Gasparini F, Triller A, Aguzzi A.

PLoS Pathog. 2017 Nov 27;13(11):e1006733. doi: 10.1371/journal.ppat.1006733. eCollection 2017 Nov.

18.

Insight into partial agonism by observing multiple equilibria for ligand-bound and Gs-mimetic nanobody-bound β1-adrenergic receptor.

Solt AS, Bostock MJ, Shrestha B, Kumar P, Warne T, Tate CG, Nietlispach D.

Nat Commun. 2017 Nov 27;8(1):1795. doi: 10.1038/s41467-017-02008-y.

19.

Sclerostin deficiency modifies the development of CKD-MBD in mice.

Kaesler N, Verhulst A, De Maré A, Deck A, Behets GJ, Hyusein A, Evenepoel P, Floege J, Marx N, Babler A, Kramer I, Kneissel M, Kramann R, Weis D, D'Haese PC, Brandenburg VM.

Bone. 2017 Nov 21;107:115-123. doi: 10.1016/j.bone.2017.11.015. [Epub ahead of print]

PMID:
29175269
20.

ICP-MS determination of serum aluminum in monkeys subcutaneously administered an alhydrogel-formulated drug candidate.

Li W, Gong J, Wang C, Lin ZJ, Flarakos J.

Bioanalysis. 2017 Dec;9(23):1873-1881. doi: 10.4155/bio-2017-0177. Epub 2017 Nov 24.

PMID:
29171771

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