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Items: 15


Synthesis of high titer infectious prions with cofactor molecules.

Supattapone S.

J Biol Chem. 2014 Jul 18;289(29):19850-4. doi: 10.1074/jbc.R113.511329. Epub 2014 May 23. Review.


Cofactor molecules maintain infectious conformation and restrict strain properties in purified prions.

Deleault NR, Walsh DJ, Piro JR, Wang F, Wang X, Ma J, Rees JR, Supattapone S.

Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):E1938-46. doi: 10.1073/pnas.1206999109. Epub 2012 Jun 18.


Isolation of phosphatidylethanolamine as a solitary cofactor for prion formation in the absence of nucleic acids.

Deleault NR, Piro JR, Walsh DJ, Wang F, Ma J, Geoghegan JC, Supattapone S.

Proc Natl Acad Sci U S A. 2012 May 29;109(22):8546-51. doi: 10.1073/pnas.1204498109. Epub 2012 May 14.


Species-dependent differences in cofactor utilization for formation of the protease-resistant prion protein in vitro.

Deleault NR, Kascsak R, Geoghegan JC, Supattapone S.

Biochemistry. 2010 May 11;49(18):3928-34. doi: 10.1021/bi100370b.


The effects of prion protein proteolysis and disaggregation on the strain properties of hamster scrapie.

Deleault AM, Deleault NR, Harris BT, Rees JR, Supattapone S.

J Gen Virol. 2008 Oct;89(Pt 10):2642-50. doi: 10.1099/vir.0.2008/002303-0.


Amplification of purified prions in vitro.

Supattapone S, Deleault NR, Rees JR.

Methods Mol Biol. 2008;459:117-30. doi: 10.1007/978-1-59745-234-2_9.


Selective incorporation of polyanionic molecules into hamster prions.

Geoghegan JC, Valdes PA, Orem NR, Deleault NR, Williamson RA, Harris BT, Supattapone S.

J Biol Chem. 2007 Dec 14;282(50):36341-53. Epub 2007 Oct 16.


Formation of native prions from minimal components in vitro.

Deleault NR, Harris BT, Rees JR, Supattapone S.

Proc Natl Acad Sci U S A. 2007 Jun 5;104(23):9741-6. Epub 2007 May 29. Erratum in: Proc Natl Acad Sci U S A. 2008 Aug 26;105(34):12636.


Accelerated accumulation of misfolded prion protein and spongiform degeneration in a Drosophila model of Gerstmann-Sträussler-Scheinker syndrome.

Gavin BA, Dolph MJ, Deleault NR, Geoghegan JC, Khurana V, Feany MB, Dolph PJ, Supattapone S.

J Neurosci. 2006 Nov 29;26(48):12408-14.


The stoichiometry of host PrPC glycoforms modulates the efficiency of PrPSc formation in vitro.

Nishina KA, Deleault NR, Mahal SP, Baskakov I, Luhrs T, Riek R, Supattapone S.

Biochemistry. 2006 Nov 28;45(47):14129-39.


Copper (II) ions potently inhibit purified PrPres amplification.

Orem NR, Geoghegan JC, Deleault NR, Kascsak R, Supattapone S.

J Neurochem. 2006 Mar;96(5):1409-15. Epub 2006 Jan 17.


Protease-resistant prion protein amplification reconstituted with partially purified substrates and synthetic polyanions.

Deleault NR, Geoghegan JC, Nishina K, Kascsak R, Williamson RA, Supattapone S.

J Biol Chem. 2005 Jul 22;280(29):26873-9. Epub 2005 May 24.


In vitro prion protein conversion in detergent-solubilized membranes.

Nishina K, Deleault NR, Lucassen RW, Supattapone S.

Biochemistry. 2004 Mar 9;43(9):2613-21.


RNA molecules stimulate prion protein conversion.

Deleault NR, Lucassen RW, Supattapone S.

Nature. 2003 Oct 16;425(6959):717-20.


Post-transcriptional suppression of pathogenic prion protein expression in Drosophila neurons.

Deleault NR, Dolph PJ, Feany MB, Cook ME, Nishina K, Harris DA, Supattapone S.

J Neurochem. 2003 Jun;85(6):1614-23.

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