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Neurosci Lett. 2015 May 6;594:76-81. doi: 10.1016/j.neulet.2015.03.059. Epub 2015 Mar 30.

Enhancement of memory consolidation by the histone deacetylase inhibitor sodium butyrate in aged rats.

Author information

1
Department of Pharmacology, Institute for Basic Health Sciences, Federal University of Rio Grande do Sul 90050-170 Porto Alegre, RS, Brazil; Cancer and Neurobiology Laboratory, University Hospital Experimental Research Center (CPE-HCPA), Federal University of Rio Grande do Sul 90035-003 Porto Alegre, Brazil; National Institute for Translational Medicine (INCT-TM), 90035-003 Porto Alegre, Brazil. Electronic address: martina.blank@ufsc.br.
2
Department of Pharmacology, Institute for Basic Health Sciences, Federal University of Rio Grande do Sul 90050-170 Porto Alegre, RS, Brazil; National Institute for Translational Medicine (INCT-TM), 90035-003 Porto Alegre, Brazil.
3
Department of Pharmacology, Institute for Basic Health Sciences, Federal University of Rio Grande do Sul 90050-170 Porto Alegre, RS, Brazil.
4
Department of Biochemistry, Federal University of Santa Catarina, 88040-900 Florianópolis, Brazil.
5
Department of Pharmacology, Institute for Basic Health Sciences, Federal University of Rio Grande do Sul 90050-170 Porto Alegre, RS, Brazil; Cancer and Neurobiology Laboratory, University Hospital Experimental Research Center (CPE-HCPA), Federal University of Rio Grande do Sul 90035-003 Porto Alegre, Brazil; National Institute for Translational Medicine (INCT-TM), 90035-003 Porto Alegre, Brazil.

Abstract

Here we show that a systemic injection of the histone deacetylase inhibitor (HDACi) sodium butyrate (NaB) immediately after training in a step-down inhibitory avoidance task produced an enhancement of memory consolidation that persisted across consecutive retention tests during 14 days in aged rats, while it did not significantly affect memory in young adults. Control aged and young adult rats showed comparable basal levels of memory retention. Our results suggest that HDACis can display memory-enhancing effects specific for aged animals, even in the absence of age-related memory impairment.

KEYWORDS:

Epigenetics; Histone deacetylase; Inhibitory avoidance; Memory consolidation; Sodium butyrate

PMID:
25837444
DOI:
10.1016/j.neulet.2015.03.059
[Indexed for MEDLINE]
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