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Int J Behav Med. 2010 Dec;17(4):314-20. doi: 10.1007/s12529-010-9117-6.

Blood pressure increases during a simulated night shift in persons at risk for hypertension.

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Department of Psychology, Clemson University, 319-B Brackett Hall, Clemson, SC 29634, USA.



Shift work with sleep disruption is a systemic stressor that may possibly be associated with blood pressure dysregulation and hypertension.


We hypothesize that rotation to a simulated night shift with sleep deprivation will produce blood pressure elevations in persons at risk for development of hypertension.


We examined the effects of a simulated night shift on resting blood pressure in 51 diurnal young adults without current hypertension. Resting blood pressure was monitored throughout a 24-h period of total sleep deprivation with sustained cognitive work. Twelve participants (23.5%) reported one or more parents with a diagnosis of hypertension. Ten participants were classified as prehypertensive by JNC-7 criteria. Only two prehypertensive subjects reported parental hypertension.


Results indicate that, as the night shift progressed, participants with a positive family history of hypertension showed significantly higher resting diastolic blood pressure than those with a negative family history of hypertension (pā€‰=ā€‰0.007). Prehypertensive participants showed elevated blood pressure throughout the study.


These data suggest that rotation to a simulated night shift with sleep deprivation may contribute to blood pressure dysregulation in persons with a positive family history of hypertension.

[Indexed for MEDLINE]

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