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Res Commun Chem Pathol Pharmacol. 1975 Sep;12(1):185-8.

Differential effect of cannabinol and cannabidiol on THC-induced responses during abstinence in morphine-dependent rats.


The same dose of cannabinol (CBN) or cannabidiol (CBD) further increased the attenuation of precipitated abstinence signs observed in morphine-dependent rats that also received an acute dose of delta 9-THC. By contrast, rotational behavior (turning), which is observed concomitantly in THC-treated rats during morphine abstinence, was not increased by CBN, but was potentiated by CBD. These data illustrate differences between psychoinactive cannabinoids in their interaction with delta 9-THC that might be relevant to possible clinical use of Cannabis in narcotic detoxification.

[Indexed for MEDLINE]

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