Format

Send to

Choose Destination
Bioinformatics. 2005 May 1;21(9):2076-82. Epub 2005 Jan 18.

Online predicted human interaction database.

Author information

1
Division of Cancer Informatics, Ontario Cancer Institute, University of Toronto, Canada.

Abstract

MOTIVATION:

High-throughput experiments are being performed at an ever-increasing rate to systematically elucidate protein-protein interaction (PPI) networks for model organisms, while the complexities of higher eukaryotes have prevented these experiments for humans.

RESULTS:

The Online Predicted Human Interaction Database (OPHID) is a web-based database of predicted interactions between human proteins. It combines the literature-derived human PPI from BIND, HPRD and MINT, with predictions made from Saccharomyces cerevisiae, Caenorhabditis elegans, Drosophila melanogaster and Mus musculus. The 23,889 predicted interactions currently listed in OPHID are evaluated using protein domains, gene co-expression and Gene Ontology terms. OPHID can be queried using single or multiple IDs and results can be visualized using our custom graph visualization program.

AVAILABILITY:

Freely available to academic users at http://ophid.utoronto.ca, both in tab-delimited and PSI-MI formats. Commercial users, please contact I.J.

CONTACT:

juris@ai.utoronto.ca

SUPPLEMENTARY INFORMATION:

http://ophid.utoronto.ca/supplInfo.pdf.

PMID:
15657099
DOI:
10.1093/bioinformatics/bti273
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Silverchair Information Systems
Loading ...
Support Center