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Items: 1 to 20 of 148

1.

Tumorigenicity of Ewing sarcoma is critically dependent on the trithorax proteins MLL1 and menin.

Svoboda LK, Bailey N, Van Noord RA, Krook MA, Harris A, Cramer C, Jasman B, Patel RM, Thomas D, Borkin D, Cierpicki T, Grembecka J, Lawlor ER.

Oncotarget. 2017 Jan 3;8(1):458-471. doi: 10.18632/oncotarget.13444.

2.

Overexpression of HOX genes is prevalent in Ewing sarcoma and is associated with altered epigenetic regulation of developmental transcription programs.

Svoboda LK, Harris A, Bailey NJ, Schwentner R, Tomazou E, von Levetzow C, Magnuson B, Ljungman M, Kovar H, Lawlor ER.

Epigenetics. 2014 Dec;9(12):1613-25. doi: 10.4161/15592294.2014.988048.

3.

Menin regulates the serine biosynthetic pathway in Ewing sarcoma.

Svoboda LK, Teh SSK, Sud S, Kerk S, Zebolsky A, Treichel S, Thomas D, Halbrook CJ, Lee HJ, Kremer D, Zhang L, Klossowski S, Bankhead AR, Magnuson B, Ljungman M, Cierpicki T, Grembecka J, Lyssiotis CA, Lawlor ER.

J Pathol. 2018 Jul;245(3):324-336. doi: 10.1002/path.5085. Epub 2018 May 28.

PMID:
29672864
4.

Psip1/Ledgf p75 restrains Hox gene expression by recruiting both trithorax and polycomb group proteins.

Pradeepa MM, Grimes GR, Taylor GC, Sutherland HG, Bickmore WA.

Nucleic Acids Res. 2014 Aug;42(14):9021-32. doi: 10.1093/nar/gku647. Epub 2014 Jul 23.

5.

The menin tumor suppressor protein is an essential oncogenic cofactor for MLL-associated leukemogenesis.

Yokoyama A, Somervaille TC, Smith KS, Rozenblatt-Rosen O, Meyerson M, Cleary ML.

Cell. 2005 Oct 21;123(2):207-18.

6.

Protein kinase Msk1 physically and functionally interacts with the KMT2A/MLL1 methyltransferase complex and contributes to the regulation of multiple target genes.

Wiersma M, Bussiere M, Halsall JA, Turan N, Slany R, Turner BM, Nightingale KP.

Epigenetics Chromatin. 2016 Nov 11;9:52. eCollection 2016.

7.

The trithorax protein partner menin acts in tandem with EZH2 to suppress C/EBPα and differentiation in MLL-AF9 leukemia.

Thiel AT, Feng Z, Pant DK, Chodosh LA, Hua X.

Haematologica. 2013 Jun;98(6):918-27. doi: 10.3324/haematol.2012.074195. Epub 2013 Jan 24.

8.

Global analysis of H3K4 methylation defines MLL family member targets and points to a role for MLL1-mediated H3K4 methylation in the regulation of transcriptional initiation by RNA polymerase II.

Wang P, Lin C, Smith ER, Guo H, Sanderson BW, Wu M, Gogol M, Alexander T, Seidel C, Wiedemann LM, Ge K, Krumlauf R, Shilatifard A.

Mol Cell Biol. 2009 Nov;29(22):6074-85. doi: 10.1128/MCB.00924-09. Epub 2009 Aug 24.

9.

Menin critically links MLL proteins with LEDGF on cancer-associated target genes.

Yokoyama A, Cleary ML.

Cancer Cell. 2008 Jul 8;14(1):36-46. doi: 10.1016/j.ccr.2008.05.003.

10.

NUP98 Fusion Proteins Interact with the NSL and MLL1 Complexes to Drive Leukemogenesis.

Xu H, Valerio DG, Eisold ME, Sinha A, Koche RP, Hu W, Chen CW, Chu SH, Brien GL, Park CY, Hsieh JJ, Ernst P, Armstrong SA.

Cancer Cell. 2016 Dec 12;30(6):863-878. doi: 10.1016/j.ccell.2016.10.019. Epub 2016 Nov 23.

11.

Interaction of MLL amino terminal sequences with menin is required for transformation.

Caslini C, Yang Z, El-Osta M, Milne TA, Slany RK, Hess JL.

Cancer Res. 2007 Aug 1;67(15):7275-83.

12.

Distinct pathways regulated by menin and by MLL1 in hematopoietic stem cells and developing B cells.

Li BE, Gan T, Meyerson M, Rabbitts TH, Ernst P.

Blood. 2013 Sep 19;122(12):2039-46. doi: 10.1182/blood-2013-03-486647. Epub 2013 Aug 1.

13.

The same pocket in menin binds both MLL and JUND but has opposite effects on transcription.

Huang J, Gurung B, Wan B, Matkar S, Veniaminova NA, Wan K, Merchant JL, Hua X, Lei M.

Nature. 2012 Feb 12;482(7386):542-6. doi: 10.1038/nature10806.

14.

Histone methyltransferase MLL1 regulates MDR1 transcription and chemoresistance.

Huo H, Magro PG, Pietsch EC, Patel BB, Scotto KW.

Cancer Res. 2010 Nov 1;70(21):8726-35. doi: 10.1158/0008-5472.CAN-10-0755. Epub 2010 Sep 22.

15.

Trithorax complex component Menin controls differentiation and maintenance of T helper 17 cells.

Watanabe Y, Onodera A, Kanai U, Ichikawa T, Obata-Ninomiya K, Wada T, Kiuchi M, Iwamura C, Tumes DJ, Shinoda K, Yagi R, Motohashi S, Hirahara K, Nakayama T.

Proc Natl Acad Sci U S A. 2014 Sep 2;111(35):12829-34. doi: 10.1073/pnas.1321245111. Epub 2014 Aug 18.

16.

Leukemia proto-oncoprotein MLL forms a SET1-like histone methyltransferase complex with menin to regulate Hox gene expression.

Yokoyama A, Wang Z, Wysocka J, Sanyal M, Aufiero DJ, Kitabayashi I, Herr W, Cleary ML.

Mol Cell Biol. 2004 Jul;24(13):5639-49.

17.

Targeting Chromatin Regulators Inhibits Leukemogenic Gene Expression in NPM1 Mutant Leukemia.

Kühn MW, Song E, Feng Z, Sinha A, Chen CW, Deshpande AJ, Cusan M, Farnoud N, Mupo A, Grove C, Koche R, Bradner JE, de Stanchina E, Vassiliou GS, Hoshii T, Armstrong SA.

Cancer Discov. 2016 Oct;6(10):1166-1181. Epub 2016 Aug 17.

18.

Menin-MLL inhibitors reverse oncogenic activity of MLL fusion proteins in leukemia.

Grembecka J, He S, Shi A, Purohit T, Muntean AG, Sorenson RJ, Showalter HD, Murai MJ, Belcher AM, Hartley T, Hess JL, Cierpicki T.

Nat Chem Biol. 2012 Jan 29;8(3):277-84. doi: 10.1038/nchembio.773.

19.

Chromatin remodelling factor Mll1 is essential for neurogenesis from postnatal neural stem cells.

Lim DA, Huang YC, Swigut T, Mirick AL, Garcia-Verdugo JM, Wysocka J, Ernst P, Alvarez-Buylla A.

Nature. 2009 Mar 26;458(7237):529-33. doi: 10.1038/nature07726. Epub 2009 Feb 11.

20.

Structural insights into inhibition of the bivalent menin-MLL interaction by small molecules in leukemia.

Shi A, Murai MJ, He S, Lund G, Hartley T, Purohit T, Reddy G, Chruszcz M, Grembecka J, Cierpicki T.

Blood. 2012 Nov 29;120(23):4461-9. doi: 10.1182/blood-2012-05-429274. Epub 2012 Aug 30.

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