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Items: 1 to 20 of 142

1.

Pharmacological Inhibition of Myocardin-related Transcription Factor Pathway Blocks Lung Metastases of RhoC-Overexpressing Melanoma.

Haak AJ, Appleton KM, Lisabeth EM, Misek SA, Ji Y, Wade SM, Bell JL, Rockwell CE, Airik M, Krook MA, Larsen SD, Verhaegen M, Lawlor ER, Neubig RR.

Mol Cancer Ther. 2017 Jan;16(1):193-204. doi: 10.1158/1535-7163.MCT-16-0482. Epub 2016 Nov 11.

2.

CCG-1423: a small-molecule inhibitor of RhoA transcriptional signaling.

Evelyn CR, Wade SM, Wang Q, Wu M, Iñiguez-Lluhí JA, Merajver SD, Neubig RR.

Mol Cancer Ther. 2007 Aug;6(8):2249-60.

3.

Myocardin-related transcription factors and SRF are required for cytoskeletal dynamics and experimental metastasis.

Medjkane S, Perez-Sanchez C, Gaggioli C, Sahai E, Treisman R.

Nat Cell Biol. 2009 Mar;11(3):257-68. doi: 10.1038/ncb1833. Epub 2009 Feb 8.

4.

Novel Rho/MRTF/SRF inhibitors block matrix-stiffness and TGF-β-induced fibrogenesis in human colonic myofibroblasts.

Johnson LA, Rodansky ES, Haak AJ, Larsen SD, Neubig RR, Higgins PD.

Inflamm Bowel Dis. 2014 Jan;20(1):154-65. doi: 10.1097/01.MIB.0000437615.98881.31.

5.

Inhibition of myocardin-related transcription factor/serum response factor signaling decreases lung fibrosis and promotes mesenchymal cell apoptosis.

Sisson TH, Ajayi IO, Subbotina N, Dodi AE, Rodansky ES, Chibucos LN, Kim KK, Keshamouni VG, White ES, Zhou Y, Higgins PD, Larsen SD, Neubig RR, Horowitz JC.

Am J Pathol. 2015 Apr;185(4):969-86. doi: 10.1016/j.ajpath.2014.12.005. Epub 2015 Feb 11.

6.

Transcription of HOTAIR is regulated by RhoC-MRTF-A-SRF signaling pathway in human breast cancer cells.

He H, Wei Z, Du F, Meng C, Zheng D, Lai Y, Yao H, Zhou H, Wang N, Luo XG, Ma W, Zhang TC.

Cell Signal. 2017 Feb;31:87-95. doi: 10.1016/j.cellsig.2017.01.003. Epub 2017 Jan 7.

PMID:
28069441
7.

Inhibition of arginyltransferase 1 induces transcriptional activity of myocardin-related transcription factor A (MRTF-A) and promotes directional migration.

Eisenach PA, Schikora F, Posern G.

J Biol Chem. 2014 Dec 19;289(51):35376-87. doi: 10.1074/jbc.M114.578674. Epub 2014 Nov 7.

8.

RPEL proteins are the molecular targets for CCG-1423, an inhibitor of Rho signaling.

Hayashi K, Watanabe B, Nakagawa Y, Minami S, Morita T.

PLoS One. 2014 Feb 18;9(2):e89016. doi: 10.1371/journal.pone.0089016. eCollection 2014.

9.

Stereospecific Inhibitory Effects of CCG-1423 on the Cellular Events Mediated by Myocardin-Related Transcription Factor A.

Watanabe B, Minami S, Ishida H, Yoshioka R, Nakagawa Y, Morita T, Hayashi K.

PLoS One. 2015 Aug 21;10(8):e0136242. doi: 10.1371/journal.pone.0136242. eCollection 2015.

10.

Targeting the myofibroblast genetic switch: inhibitors of myocardin-related transcription factor/serum response factor-regulated gene transcription prevent fibrosis in a murine model of skin injury.

Haak AJ, Tsou PS, Amin MA, Ruth JH, Campbell P, Fox DA, Khanna D, Larsen SD, Neubig RR.

J Pharmacol Exp Ther. 2014 Jun;349(3):480-6. doi: 10.1124/jpet.114.213520. Epub 2014 Apr 4.

11.

The role of RhoC in growth and metastatic capacity of melanoma.

Boone B, Van Gele M, Lambert J, Haspeslagh M, Brochez L.

J Cutan Pathol. 2009 Jun;36(6):629-36. doi: 10.1111/j.1600-0560.2008.01117.x. Epub 2009 Feb 5.

PMID:
19222696
12.

Rb-Raf-1 interaction disruptor RRD-251 induces apoptosis in metastatic melanoma cells and synergizes with dacarbazine.

Singh S, Davis R, Alamanda V, Pireddu R, Pernazza D, Sebti S, Lawrence N, Chellappan S.

Mol Cancer Ther. 2010 Dec;9(12):3330-41. doi: 10.1158/1535-7163.MCT-10-0442. Epub 2010 Dec 7.

13.

A novel strategy for specifically down-regulating individual Rho GTPase activity in tumor cells.

Wang L, Yang L, Luo Y, Zheng Y.

J Biol Chem. 2003 Nov 7;278(45):44617-25. Epub 2003 Aug 25.

14.

Myocardin-related transcription factor A (MRTF-A) activity-dependent cell adhesion is correlated to focal adhesion kinase (FAK) activity.

Kishi T, Mayanagi T, Iwabuchi S, Akasaka T, Sobue K.

Oncotarget. 2016 Nov 1;7(44):72113-72130. doi: 10.18632/oncotarget.12350.

15.

Nuclear RhoA signaling regulates MRTF-dependent SMC-specific transcription.

Staus DP, Weise-Cross L, Mangum KD, Medlin MD, Mangiante L, Taylor JM, Mack CP.

Am J Physiol Heart Circ Physiol. 2014 Aug 1;307(3):H379-90. doi: 10.1152/ajpheart.01002.2013. Epub 2014 Jun 6.

16.

Cell cycle arrest and apoptosis of melanoma cells by docosahexaenoic acid: association with decreased pRb phosphorylation.

Albino AP, Juan G, Traganos F, Reinhart L, Connolly J, Rose DP, Darzynkiewicz Z.

Cancer Res. 2000 Aug 1;60(15):4139-45.

17.

Antimetastatic effect of salvicine on human breast cancer MDA-MB-435 orthotopic xenograft is closely related to Rho-dependent pathway.

Lang JY, Chen H, Zhou J, Zhang YX, Zhang XW, Li MH, Lin LP, Zhang JS, Waalkes MP, Ding J.

Clin Cancer Res. 2005 May 1;11(9):3455-64.

18.

Reduction of lung metastasis, cell invasion, and adhesion in mouse melanoma by statin-induced blockade of the Rho/Rho-associated coiled-coil-containing protein kinase pathway.

Kidera Y, Tsubaki M, Yamazoe Y, Shoji K, Nakamura H, Ogaki M, Satou T, Itoh T, Isozaki M, Kaneko J, Tanimori Y, Yanae M, Nishida S.

J Exp Clin Cancer Res. 2010 Sep 16;29:127. doi: 10.1186/1756-9966-29-127.

19.

Inhibition of Ovarian Epithelial Carcinoma Tumorigenesis and Progression by microRNA 106b Mediated through the RhoC Pathway.

Chen S, Chen X, Xiu YL, Sun KX, Zhao Y.

PLoS One. 2015 May 1;10(5):e0125714. doi: 10.1371/journal.pone.0125714. eCollection 2015.

20.

Inhibition of invasion and metastasis of hepatocellular carcinoma cells via targeting RhoC in vitro and in vivo.

Wang W, Wu F, Fang F, Tao Y, Yang L.

Clin Cancer Res. 2008 Nov 1;14(21):6804-12. doi: 10.1158/1078-0432.CCR-07-4820.

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