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Items: 1 to 20 of 89

1.

Small-Molecule Inhibition of Rho/MKL/SRF Transcription in Prostate Cancer Cells: Modulation of Cell Cycle, ER Stress, and Metastasis Gene Networks.

Evelyn CR, Lisabeth EM, Wade SM, Haak AJ, Johnson CN, Lawlor ER, Neubig RR.

Microarrays (Basel). 2016 May 28;5(2). pii: E13. doi: 10.3390/microarrays5020013.

2.

CCG-1423: a small-molecule inhibitor of RhoA transcriptional signaling.

Evelyn CR, Wade SM, Wang Q, Wu M, Iñiguez-Lluhí JA, Merajver SD, Neubig RR.

Mol Cancer Ther. 2007 Aug;6(8):2249-60.

3.

Pharmacological Inhibition of Myocardin-related Transcription Factor Pathway Blocks Lung Metastases of RhoC-Overexpressing Melanoma.

Haak AJ, Appleton KM, Lisabeth EM, Misek SA, Ji Y, Wade SM, Bell JL, Rockwell CE, Airik M, Krook MA, Larsen SD, Verhaegen M, Lawlor ER, Neubig RR.

Mol Cancer Ther. 2017 Jan;16(1):193-204. doi: 10.1158/1535-7163.MCT-16-0482. Epub 2016 Nov 11.

5.

The myocardin-related transcription factor MKL co-regulates the cellular levels of two profilin isoforms.

Joy M, Gau D, Castellucci N, Prywes R, Roy P.

J Biol Chem. 2017 Jul 14;292(28):11777-11791. doi: 10.1074/jbc.M117.781104. Epub 2017 May 25.

6.

RhoA as a mediator of clinically relevant androgen action in prostate cancer cells.

Schmidt LJ, Duncan K, Yadav N, Regan KM, Verone AR, Lohse CM, Pop EA, Attwood K, Wilding G, Mohler JL, Sebo TJ, Tindall DJ, Heemers HV.

Mol Endocrinol. 2012 May;26(5):716-35. doi: 10.1210/me.2011-1130. Epub 2012 Mar 28.

7.

Delayed stress fiber formation mediates pulmonary myofibroblast differentiation in response to TGF-β.

Sandbo N, Lau A, Kach J, Ngam C, Yau D, Dulin NO.

Am J Physiol Lung Cell Mol Physiol. 2011 Nov;301(5):L656-66. doi: 10.1152/ajplung.00166.2011. Epub 2011 Aug 19.

8.
9.

Involvement of the serum response factor coactivator megakaryoblastic leukemia (MKL) in the activin-regulated dendritic complexity of rat cortical neurons.

Ishikawa M, Nishijima N, Shiota J, Sakagami H, Tsuchida K, Mizukoshi M, Fukuchi M, Tsuda M, Tabuchi A.

J Biol Chem. 2010 Oct 22;285(43):32734-43. doi: 10.1074/jbc.M110.118745. Epub 2010 Aug 13.

10.

The RhoA/Rho kinase pathway regulates nuclear localization of serum response factor.

Liu HW, Halayko AJ, Fernandes DJ, Harmon GS, McCauley JA, Kocieniewski P, McConville J, Fu Y, Forsythe SM, Kogut P, Bellam S, Dowell M, Churchill J, Lesso H, Kassiri K, Mitchell RW, Hershenson MB, Camoretti-Mercado B, Solway J.

Am J Respir Cell Mol Biol. 2003 Jul;29(1):39-47. Epub 2003 Jan 10.

PMID:
12600823
11.

Actin-mediated gene expression depends on RhoA and Rac1 signaling in proximal tubular epithelial cells.

Giehl K, Keller C, Muehlich S, Goppelt-Struebe M.

PLoS One. 2015 Mar 27;10(3):e0121589. doi: 10.1371/journal.pone.0121589. eCollection 2015.

12.

Myocardin/MKL family of SRF coactivators: key regulators of immediate early and muscle specific gene expression.

Cen B, Selvaraj A, Prywes R.

J Cell Biochem. 2004 Sep 1;93(1):74-82. Review.

PMID:
15352164
13.

Galphaz inhibits serum response factor-dependent transcription by inhibiting Rho signaling.

Dutt P, Jaffe AB, Merdek KD, Hall A, Toksoz D.

Mol Pharmacol. 2004 Dec;66(6):1508-16. Epub 2004 Aug 23.

14.

Smooth muscle differentiation marker gene expression is regulated by RhoA-mediated actin polymerization.

Mack CP, Somlyo AV, Hautmann M, Somlyo AP, Owens GK.

J Biol Chem. 2001 Jan 5;276(1):341-7.

15.

cAMP-induced actin cytoskeleton remodelling inhibits MKL1-dependent expression of the chemotactic and pro-proliferative factor, CCN1.

Duggirala A, Kimura TE, Sala-Newby GB, Johnson JL, Wu YJ, Newby AC, Bond M.

J Mol Cell Cardiol. 2015 Feb;79:157-68. doi: 10.1016/j.yjmcc.2014.11.012. Epub 2014 Nov 18.

16.

cGMP-dependent protein kinase inhibits serum-response element-dependent transcription by inhibiting rho activation and functions.

Gudi T, Chen JC, Casteel DE, Seasholtz TM, Boss GR, Pilz RB.

J Biol Chem. 2002 Oct 4;277(40):37382-93. Epub 2002 Jul 15.

17.

A p27(kip1)-binding protein, p27RF-Rho, promotes cancer metastasis via activation of RhoA and RhoC.

Hoshino D, Koshikawa N, Seiki M.

J Biol Chem. 2011 Jan 28;286(4):3139-48. doi: 10.1074/jbc.M110.159715. Epub 2010 Nov 17.

18.

[Serum response factor participates in RhoA-induced endothelial cell F-actin rearrangements].

Han YL, Yu HB, Yan CH, Meng ZM, Zhang XL, Kang J, Li SH, Wang SW.

Sheng Li Xue Bao. 2005 Jun 25;57(3):295-302. Chinese.

20.

Control of myofibroblast differentiation by microtubule dynamics through a regulated localization of mDia2.

Sandbo N, Ngam C, Torr E, Kregel S, Kach J, Dulin N.

J Biol Chem. 2013 May 31;288(22):15466-73. doi: 10.1074/jbc.M113.464461. Epub 2013 Apr 11.

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