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Items: 1 to 20 of 81

1.

Progress Toward the Development of Noscapine and Derivatives as Anticancer Agents.

DeBono A, Capuano B, Scammells PJ.

J Med Chem. 2015 Aug 13;58(15):5699-727. doi: 10.1021/jm501180v. Epub 2015 Apr 16.

PMID:
25811651
2.

The synthesis and biological evaluation of multifunctionalised derivatives of noscapine as cytotoxic agents.

Debono AJ, Mistry SJ, Xie J, Muthiah D, Phillips J, Ventura S, Callaghan R, Pouton CW, Capuano B, Scammells PJ.

ChemMedChem. 2014 Feb;9(2):399-410. doi: 10.1002/cmdc.201300395. Epub 2013 Dec 11.

PMID:
24339417
3.

Noscapine comes of age.

Chen X, Dang TT, Facchini PJ.

Phytochemistry. 2015 Mar;111:7-13. doi: 10.1016/j.phytochem.2014.09.008. Epub 2015 Jan 9. Review.

PMID:
25583437
4.

The Noscapine Chronicle: A Pharmaco-Historic Biography of the Opiate Alkaloid Family and its Clinical Applications.

Rida PC, LiVecche D, Ogden A, Zhou J, Aneja R.

Med Res Rev. 2015 Sep;35(5):1072-96. doi: 10.1002/med.21357. Epub 2015 Jul 14. Review.

5.

The anti-cancer activity of noscapine: a review.

Mahmoudian M, Rahimi-Moghaddam P.

Recent Pat Anticancer Drug Discov. 2009 Jan;4(1):92-7. Review.

PMID:
19149691
6.

Taking aim at a dynamic target: Noscapinoids as microtubule-targeted cancer therapeutics.

Lopus M, Naik PK.

Pharmacol Rep. 2015 Feb;67(1):56-62. doi: 10.1016/j.pharep.2014.09.003. Epub 2014 Sep 20. Review.

PMID:
25560576
7.

Noscapine induces mitochondria-mediated apoptosis in human colon cancer cells in vivo and in vitro.

Yang ZR, Liu M, Peng XL, Lei XF, Zhang JX, Dong WG.

Biochem Biophys Res Commun. 2012 May 11;421(3):627-33. doi: 10.1016/j.bbrc.2012.04.079. Epub 2012 Apr 22.

PMID:
22546556
8.

Synthesis and biological evaluation of N-substituted noscapine analogues.

DeBono AJ, Xie JH, Ventura S, Pouton CW, Capuano B, Scammells PJ.

ChemMedChem. 2012 Dec;7(12):2122-33. doi: 10.1002/cmdc.201200365. Epub 2012 Oct 10.

PMID:
23055449
9.

A Papaver somniferum 10-gene cluster for synthesis of the anticancer alkaloid noscapine.

Winzer T, Gazda V, He Z, Kaminski F, Kern M, Larson TR, Li Y, Meade F, Teodor R, Vaistij FE, Walker C, Bowser TA, Graham IA.

Science. 2012 Jun 29;336(6089):1704-8. doi: 10.1126/science.1220757. Epub 2012 May 31.

10.

Induction of acetylation and bundling of cellular microtubules by 9-(4-vinylphenyl) noscapine elicits S-phase arrest in MDA-MB-231 cells.

Cheriyamundath S, Mahaddalkar T, Kantevari S, Lopus M.

Biomed Pharmacother. 2017 Feb;86:74-80. doi: 10.1016/j.biopha.2016.11.143. Epub 2016 Dec 7.

PMID:
27939522
11.

Noscapine inhibits tumor growth with little toxicity to normal tissues or inhibition of immune responses.

Ke Y, Ye K, Grossniklaus HE, Archer DR, Joshi HC, Kapp JA.

Cancer Immunol Immunother. 2000 Jul;49(4-5):217-25.

PMID:
10941904
12.

Development of a novel nitro-derivative of noscapine for the potential treatment of drug-resistant ovarian cancer and T-cell lymphoma.

Aneja R, Vangapandu SN, Lopus M, Chandra R, Panda D, Joshi HC.

Mol Pharmacol. 2006 Jun;69(6):1801-9. Epub 2006 Mar 3. Erratum in: Mol Pharmacol. 2007 Aug;72(2):486.

PMID:
16517755
13.

Engineering biosynthesis of the anticancer alkaloid noscapine in yeast.

Li Y, Smolke CD.

Nat Commun. 2016 Jul 5;7:12137. doi: 10.1038/ncomms12137.

14.

Paclitaxel-resistant human ovarian cancer cells undergo c-Jun NH2-terminal kinase-mediated apoptosis in response to noscapine.

Zhou J, Gupta K, Yao J, Ye K, Panda D, Giannakakou P, Joshi HC.

J Biol Chem. 2002 Oct 18;277(42):39777-85. Epub 2002 Aug 14.

15.

Synthesis of microtubule-interfering halogenated noscapine analogs that perturb mitosis in cancer cells followed by cell death.

Aneja R, Vangapandu SN, Lopus M, Viswesarappa VG, Dhiman N, Verma A, Chandra R, Panda D, Joshi HC.

Biochem Pharmacol. 2006 Aug 14;72(4):415-26. Epub 2006 May 10.

PMID:
16780803
16.

Identification of novel and improved antimitotic agents derived from noscapine.

Anderson JT, Ting AE, Boozer S, Brunden KR, Crumrine C, Danzig J, Dent T, Faga L, Harrington JJ, Hodnick WF, Murphy SM, Pawlowski G, Perry R, Raber A, Rundlett SE, Stricker-Krongrad A, Wang J, Bennani YL.

J Med Chem. 2005 Nov 17;48(23):7096-8.

PMID:
16279766
17.

A review on noscapine, and its impact on heme metabolism.

Singh H, Singh P, Kumari K, Chandra A, Dass SK, Chandra R.

Curr Drug Metab. 2013 Mar;14(3):351-60. Review.

PMID:
22935070
18.

Discovery of S-phase arresting agents derived from noscapine.

Anderson JT, Ting AE, Boozer S, Brunden KR, Danzig J, Dent T, Harrington JJ, Murphy SM, Perry R, Raber A, Rundlett SE, Wang J, Wang N, Bennani YL.

J Med Chem. 2005 Apr 21;48(8):2756-8.

PMID:
15828811
19.

CYLD Regulates Noscapine Activity in Acute Lymphoblastic Leukemia via a Microtubule-Dependent Mechanism.

Yang Y, Ran J, Sun L, Sun X, Luo Y, Yan B, Tala, Liu M, Li D, Zhang L, Bao G, Zhou J.

Theranostics. 2015 Mar 2;5(7):656-66. doi: 10.7150/thno.10844. eCollection 2015.

20.

Tubulin binding, protein-bound conformation in solution, and antimitotic cellular profiling of noscapine and its derivatives.

Bennani YL, Gu W, Canales A, Díaz FJ, Eustace BK, Hoover RR, Jiménez-Barbero J, Nezami A, Wang T.

J Med Chem. 2012 Mar 8;55(5):1920-5. doi: 10.1021/jm200848t. Epub 2012 Feb 27.

PMID:
22320354

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