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Items: 1 to 20 of 374

1.

Investigation of podophyllotoxin esters as potential anticancer agents: synthesis, biological studies and tubulin inhibition properties.

Shareef MA, Duscharla D, Ramasatyaveni G, Dhoke NR, Das A, Ummanni R, Srivastava AK.

Eur J Med Chem. 2015 Jan 7;89:128-37. doi: 10.1016/j.ejmech.2014.10.050. Epub 2014 Oct 18.

PMID:
25462233
2.

Synthesis of a terphenyl substituted 4-aza-2,3-didehydropodophyllotoxin analogues as inhibitors of tubulin polymerization and apoptosis inducers.

Kamal A, Tamboli JR, Nayak VL, Adil SF, Vishnuvardhan MV, Ramakrishna S.

Bioorg Med Chem. 2014 May 1;22(9):2714-23. doi: 10.1016/j.bmc.2014.03.021. Epub 2014 Mar 22.

PMID:
24721832
3.

Synthesis and biological evaluation of podophyllotoxin congeners as tubulin polymerization inhibitors.

Kamal A, Srinivasa Reddy T, Polepalli S, Shalini N, Reddy VG, Subba Rao AV, Jain N, Shankaraiah N.

Bioorg Med Chem. 2014 Oct 1;22(19):5466-75. doi: 10.1016/j.bmc.2014.07.031. Epub 2014 Jul 27.

PMID:
25131956
4.

Synthesis and biological evaluation of a series of podophyllotoxins derivatives as a class of potent antitubulin agents.

Liu Y, Wei D, Zhao Y, Cheng W, Lu Y, Ma Y, Li X, Han C, Wei Y, Cao H, Zhao C.

Bioorg Med Chem. 2012 Nov 1;20(21):6285-95. doi: 10.1016/j.bmc.2012.09.009. Epub 2012 Sep 13.

PMID:
23022053
5.

Design, synthesis, biological evaluation, and 3D-QSAR analysis of podophyllotoxin-dioxazole combination as tubulin targeting anticancer agents.

Wang ZZ, Sun WX, Wang X, Zhang YH, Qiu HY, Qi JL, Pang YJ, Lu GH, Wang XM, Yu FG, Yang YH.

Chem Biol Drug Des. 2017 Aug;90(2):236-243. doi: 10.1111/cbdd.12942. Epub 2017 Feb 28.

PMID:
28079286
6.

Design and synthesis of piperazine acetate podophyllotoxin ester derivatives targeting tubulin depolymerization as new anticancer agents.

Sun WX, Ji YJ, Wan Y, Han HW, Lin HY, Lu GH, Qi JL, Wang XM, Yang YH.

Bioorg Med Chem Lett. 2017 Sep 1;27(17):4066-4074. doi: 10.1016/j.bmcl.2017.07.047. Epub 2017 Jul 20.

PMID:
28757065
7.

Synthesis and Biological evaluation of novel 4β-[(5-substituted)-1,2,3,4-tetrazolyl] podophyllotoxins as anticancer compounds.

Hyder I, Yedlapudi D, Kalivendi SV, Khazir J, Ismail T, Nalla N, Miryala S, Sampath Kumar HM.

Bioorg Med Chem Lett. 2015 Jul 15;25(14):2860-3. doi: 10.1016/j.bmcl.2015.04.053. Epub 2015 May 5.

PMID:
26022842
8.

Synthesis and biological evaluation of 4-aza-2,3-dihydropyridophenanthrolines as tubulin polymerization inhibitors.

Kamal A, Srinivasa Reddy T, Polepalli S, Paidakula S, Srinivasulu V, Ganga Reddy V, Jain N, Shankaraiah N.

Bioorg Med Chem Lett. 2014 Aug 1;24(15):3356-60. doi: 10.1016/j.bmcl.2014.05.096. Epub 2014 Jun 6.

PMID:
24953821
9.

Design, synthesis and biological evaluation of novel pyrazoline-containing derivatives as potential tubulin assembling inhibitors.

Qin YJ, Li YJ, Jiang AQ, Yang MR, Zhu QZ, Dong H, Zhu HL.

Eur J Med Chem. 2015 Apr 13;94:447-57. doi: 10.1016/j.ejmech.2015.02.058. Epub 2015 Mar 3.

PMID:
25828827
10.

Synthesis and biological evaluation of 1,2,3-triazole linked aminocombretastatin conjugates as mitochondrial mediated apoptosis inducers.

Kamal A, Shaik B, Nayak VL, Nagaraju B, Kapure JS, Shaheer Malik M, Shaik TB, Prasad B.

Bioorg Med Chem. 2014 Oct 1;22(19):5155-67. doi: 10.1016/j.bmc.2014.08.008. Epub 2014 Aug 19.

PMID:
25192811
11.

1,3,4-oxadiazole-2-thione Derivatives; Novel Approach for Anticancer and Tubulin Polymerization Inhibitory Activities.

Abdel-Aziz M, Metwally KA, Gamal-Eldeen AM, Aly OM.

Anticancer Agents Med Chem. 2015;16(2):269-77.

PMID:
26343141
12.

Design, synthesis and biological evaluation of a series of pyrano chalcone derivatives containing indole moiety as novel anti-tubulin agents.

Wang G, Li C, He L, Lei K, Wang F, Pu Y, Yang Z, Cao D, Ma L, Chen J, Sang Y, Liang X, Xiang M, Peng A, Wei Y, Chen L.

Bioorg Med Chem. 2014 Apr 1;22(7):2060-79. doi: 10.1016/j.bmc.2014.02.028. Epub 2014 Mar 1.

PMID:
24629450
13.

Design, synthesis and biological evaluations of chirally pure 1,2,3,4-tertrahydroisoquinoline analogs as anti-cancer agents.

Ramanivas T, Sushma B, Nayak VL, Chandra Shekar K, Srivastava AK.

Eur J Med Chem. 2015 Mar 6;92:608-18. doi: 10.1016/j.ejmech.2015.01.030. Epub 2015 Jan 15.

PMID:
25615796
14.

Synthesis and biological evaluation of benzo[b]furo[3,4-e][1,4]diazepin-1-one derivatives as anti-cancer agents.

Malayeri SO, Tayarani-Najaran Z, Behbahani FS, Rashidi R, Delpazir S, Ghodsi R.

Bioorg Chem. 2018 Oct;80:631-638. doi: 10.1016/j.bioorg.2018.07.023. Epub 2018 Jul 19.

PMID:
30041139
15.

Biological evaluation and molecular modelling study of podophyllotoxin derivatives as potent inhibitors of tubulin polymerization.

Ma Y, Fang S, Li H, Han C, Lu Y, Zhao Y, Liu Y, Zhao C.

Chem Biol Drug Des. 2013 Jul;82(1):12-21. doi: 10.1111/cbdd.12130.

PMID:
23786349
16.

Design and synthesis of pyrazole/isoxazole linked arylcinnamides as tubulin polymerization inhibitors and potential antiproliferative agents.

Kamal A, Shaik AB, Rao BB, Khan I, Bharath Kumar G, Jain N.

Org Biomol Chem. 2015 Oct 28;13(40):10162-78. doi: 10.1039/c5ob01257k. Epub 2015 Aug 25.

PMID:
26303171
17.

Synthesis and biological evaluation of imidazo[1,5-a]pyridine-benzimidazole hybrids as inhibitors of both tubulin polymerization and PI3K/Akt pathway.

Kamal A, Rao AV, Nayak VL, Reddy NV, Swapna K, Ramakrishna G, Alvala M.

Org Biomol Chem. 2014 Dec 28;12(48):9864-80. doi: 10.1039/c4ob01930j.

PMID:
25354805
18.

Synthesis and cytotoxicity evaluation of novel podophyllotoxin derivatives.

Chengniu W, Zhonghua W, Yu Z, Chunyan N, Xiaodong Z, Li Z.

Arch Pharm (Weinheim). 2011 Nov;344(11):735-40. doi: 10.1002/ardp.201100095. Epub 2011 Sep 2.

PMID:
21887802
19.

Synthesis of a new 4-aza-2,3-didehydropodophyllotoxin analogues as potent cytotoxic and antimitotic agents.

Kamal A, Suresh P, Mallareddy A, Kumar BA, Reddy PV, Raju P, Tamboli JR, Shaik TB, Jain N, Kalivendi SV.

Bioorg Med Chem. 2011 Apr 1;19(7):2349-58. doi: 10.1016/j.bmc.2011.02.020. Epub 2011 Feb 24.

PMID:
21402478
20.

Synthesis and anticancer activity of dichloroplatinum(II) complexes of podophyllotoxin.

Liu X, Zhang LL, Xu XH, Hui L, Zhang JB, Chen SW.

Bioorg Med Chem Lett. 2013 Jul 1;23(13):3780-4. doi: 10.1016/j.bmcl.2013.04.089. Epub 2013 May 9.

PMID:
23711918

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