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Items: 1 to 20 of 114


miR-17~92 cooperates with RB pathway mutations to promote retinoblastoma.

Conkrite K, Sundby M, Mukai S, Thomson JM, Mu D, Hammond SM, MacPherson D.

Genes Dev. 2011 Aug 15;25(16):1734-45. doi: 10.1101/gad.17027411. Epub 2011 Aug 4.


Co-deleting Pten with Rb in retinal progenitor cells in mice results in fully penetrant bilateral retinoblastomas.

Xie C, Lu H, Nomura A, Hanse EA, Forster CL, Parker JB, Linden MA, Karasch C, Hallstrom TC.

Mol Cancer. 2015 Apr 24;14:93. doi: 10.1186/s12943-015-0360-y.


Cooperation between Rb and Arf in suppressing mouse retinoblastoma.

Conkrite K, Sundby M, Mu D, Mukai S, MacPherson D.

J Clin Invest. 2012 May;122(5):1726-33. doi: 10.1172/JCI61403. Epub 2012 Apr 9.


Retinoblastoma family proteins have distinct functions in pulmonary epithelial cells in vivo critical for suppressing cell growth and tumorigenesis.

Simpson DS, Mason-Richie NA, Gettler CA, Wikenheiser-Brokamp KA.

Cancer Res. 2009 Nov 15;69(22):8733-41. doi: 10.1158/0008-5472.CAN-09-1359. Epub 2009 Nov 3.


Compensation by tumor suppressor genes during retinal development in mice and humans.

Donovan SL, Schweers B, Martins R, Johnson D, Dyer MA.

BMC Biol. 2006 May 3;4:14.


Cell-specific effects of RB or RB/p107 loss on retinal development implicate an intrinsically death-resistant cell-of-origin in retinoblastoma.

Chen D, Livne-bar I, Vanderluit JL, Slack RS, Agochiya M, Bremner R.

Cancer Cell. 2004 Jun;5(6):539-51.


Seed-targeting anti-miR-21 inhibiting malignant progression of retinoblastoma and analysis of their phosphorylation signaling pathways.

Ding Y, Wu M, Liu J, Wu C, Huang R, Zhu R, Fei J.

Exp Eye Res. 2014 May;122:1-8. doi: 10.1016/j.exer.2014.02.017. Epub 2014 Mar 7.


Cell type-specific effects of Rb deletion in the murine retina.

MacPherson D, Sage J, Kim T, Ho D, McLaughlin ME, Jacks T.

Genes Dev. 2004 Jul 15;18(14):1681-94. Epub 2004 Jul 1.


miR than meets the eye.

Sage J, Ventura A.

Genes Dev. 2011 Aug 15;25(16):1663-7. doi: 10.1101/gad.17454011.


p107 is a suppressor of retinoblastoma development in pRb-deficient mice.

Robanus-Maandag E, Dekker M, van der Valk M, Carrozza ML, Jeanny JC, Dannenberg JH, Berns A, te Riele H.

Genes Dev. 1998 Jun 1;12(11):1599-609.


The RB protein family in retinal development and retinoblastoma: new insights from new mouse models.

Bremner R, Chen D, Pacal M, Livne-Bar I, Agochiya M.

Dev Neurosci. 2004;26(5-6):417-34. Review.


Synthetic lethality between Rb, p53 and Dicer or miR-17-92 in retinal progenitors suppresses retinoblastoma formation.

Nittner D, Lambertz I, Clermont F, Mestdagh P, Köhler C, Nielsen SJ, Jochemsen A, Speleman F, Vandesompele J, Dyer MA, Schramm A, Schulte JH, Marine JC.

Nat Cell Biol. 2012 Sep;14(9):958-65. doi: 10.1038/ncb2556. Epub 2012 Aug 5.


Rb suppresses human cone-precursor-derived retinoblastoma tumours.

Xu XL, Singh HP, Wang L, Qi DL, Poulos BK, Abramson DH, Jhanwar SC, Cobrinik D.

Nature. 2014 Oct 16;514(7522):385-8. doi: 10.1038/nature13813. Epub 2014 Sep 24.


Proliferative suppression by CDK4/6 inhibition: complex function of the retinoblastoma pathway in liver tissue and hepatoma cells.

Rivadeneira DB, Mayhew CN, Thangavel C, Sotillo E, Reed CA, Graña X, Knudsen ES.

Gastroenterology. 2010 May;138(5):1920-30. doi: 10.1053/j.gastro.2010.01.007. Epub 2010 Jan 25.


Oncogenic microRNA 17-92 cluster is regulated by epithelial cell adhesion molecule and could be a potential therapeutic target in retinoblastoma.

Kandalam MM, Beta M, Maheswari UK, Swaminathan S, Krishnakumar S.

Mol Vis. 2012;18:2279-87. Epub 2012 Aug 28.


MiR-21 inhibitor suppressed the progression of retinoblastoma via the modulation of PTEN/PI3K/AKT pathway.

Gui F, Hong Z, You Z, Wu H, Zhang Y.

Cell Biol Int. 2016 Dec;40(12):1294-1302. doi: 10.1002/cbin.10678. Epub 2016 Sep 27.


Distinct roles for p107 and p130 in Rb-independent cellular senescence.

Lehmann BD, Brooks AM, Paine MS, Chappell WH, McCubrey JA, Terrian DM.

Cell Cycle. 2008 May 1;7(9):1262-8. Epub 2008 Mar 7.


Retinoblastoma gene-independent G1 phase arrest by flavone, phosphatidylinositol 3-kinase inhibitor, and histone deacetylase inhibitor.

Tomosugi M, Sowa Y, Yasuda S, Tanaka R, te Riele H, Ikawa H, Koyama M, Sakai T.

Cancer Sci. 2012 Dec;103(12):2139-43. doi: 10.1111/cas.12012. Epub 2012 Oct 26.


Rb and p107 are required for alpha cell survival, beta cell cycle control and glucagon-like peptide-1 action.

Cai EP, Luk CT, Wu X, Schroer SA, Shi SY, Sivasubramaniyam T, Brunt JJ, Zacksenhaus E, Woo M.

Diabetologia. 2014 Dec;57(12):2555-65. doi: 10.1007/s00125-014-3381-y. Epub 2014 Sep 24.


The first knockout mouse model of retinoblastoma.

Zhang J, Schweers B, Dyer MA.

Cell Cycle. 2004 Jul;3(7):952-9. Epub 2004 Jul 3.


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