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Items: 1 to 20 of 89

1.

NLRX1 protein attenuates inflammatory responses to infection by interfering with the RIG-I-MAVS and TRAF6-NF-κB signaling pathways.

Allen IC, Moore CB, Schneider M, Lei Y, Davis BK, Scull MA, Gris D, Roney KE, Zimmermann AG, Bowzard JB, Ranjan P, Monroe KM, Pickles RJ, Sambhara S, Ting JP.

Immunity. 2011 Jun 24;34(6):854-65. doi: 10.1016/j.immuni.2011.03.026.

2.

NLRX1 is a regulator of mitochondrial antiviral immunity.

Moore CB, Bergstralh DT, Duncan JA, Lei Y, Morrison TE, Zimmermann AG, Accavitti-Loper MA, Madden VJ, Sun L, Ye Z, Lich JD, Heise MT, Chen Z, Ting JP.

Nature. 2008 Jan 31;451(7178):573-7. doi: 10.1038/nature06501. Epub 2008 Jan 16.

PMID:
18200010
3.

NLRX1 does not inhibit MAVS-dependent antiviral signalling.

Soares F, Tattoli I, Wortzman ME, Arnoult D, Philpott DJ, Girardin SE.

Innate Immun. 2013;19(4):438-48. doi: 10.1177/1753425912467383. Epub 2012 Dec 4.

PMID:
23212541
4.

NLRX1 negatively regulates TLR-induced NF-κB signaling by targeting TRAF6 and IKK.

Xia X, Cui J, Wang HY, Zhu L, Matsueda S, Wang Q, Yang X, Hong J, Songyang Z, Chen ZJ, Wang RF.

Immunity. 2011 Jun 24;34(6):843-53. doi: 10.1016/j.immuni.2011.02.022.

5.

FAS-associated factor-1 positively regulates type I interferon response to RNA virus infection by targeting NLRX1.

Kim JH, Park ME, Nikapitiya C, Kim TH, Uddin MB, Lee HC, Kim E, Ma JY, Jung JU, Kim CJ, Lee JS.

PLoS Pathog. 2017 May 22;13(5):e1006398. doi: 10.1371/journal.ppat.1006398. eCollection 2017 May. Erratum in: PLoS Pathog. 2018 Sep 21;14(9):e1007302.

7.

Scaffolding adaptor protein Gab1 is required for TLR3/4- and RIG-I-mediated production of proinflammatory cytokines and type I IFN in macrophages.

Zheng Y, An H, Yao M, Hou J, Yu Y, Feng G, Cao X.

J Immunol. 2010 Jun 1;184(11):6447-56. doi: 10.4049/jimmunol.0901750. Epub 2010 Apr 30.

8.

Methylcrotonoyl-CoA carboxylase 1 potentiates RLR-induced NF-κB signaling by targeting MAVS complex.

Cao Z, Xia Z, Zhou Y, Yang X, Hao H, Peng N, Liu S, Zhu Y.

Sci Rep. 2016 Sep 15;6:33557. doi: 10.1038/srep33557.

9.

RIG-I Signaling Is Critical for Efficient Polyfunctional T Cell Responses during Influenza Virus Infection.

Kandasamy M, Suryawanshi A, Tundup S, Perez JT, Schmolke M, Manicassamy S, Manicassamy B.

PLoS Pathog. 2016 Jul 20;12(7):e1005754. doi: 10.1371/journal.ppat.1005754. eCollection 2016 Jul.

10.

TRAF6 establishes innate immune responses by activating NF-kappaB and IRF7 upon sensing cytosolic viral RNA and DNA.

Konno H, Yamamoto T, Yamazaki K, Gohda J, Akiyama T, Semba K, Goto H, Kato A, Yujiri T, Imai T, Kawaguchi Y, Su B, Takeuchi O, Akira S, Tsunetsugu-Yokota Y, Inoue J.

PLoS One. 2009 May 25;4(5):e5674. doi: 10.1371/journal.pone.0005674.

11.

NLRX1 attenuates apoptosis and inflammatory responses in myocardial ischemia by inhibiting MAVS-dependent NLRP3 inflammasome activation.

Li H, Zhang S, Li F, Qin L.

Mol Immunol. 2016 Aug;76:90-7. doi: 10.1016/j.molimm.2016.06.013. Epub 2016 Jul 6.

PMID:
27393910
12.

NLRX1 promotes immediate IRF1-directed antiviral responses by limiting dsRNA-activated translational inhibition mediated by PKR.

Feng H, Lenarcic EM, Yamane D, Wauthier E, Mo J, Guo H, McGivern DR, González-López O, Misumi I, Reid LM, Whitmire JK, Ting JP, Duncan JA, Moorman NJ, Lemon SM.

Nat Immunol. 2017 Dec;18(12):1299-1309. doi: 10.1038/ni.3853. Epub 2017 Oct 2.

13.

The mitochondrial proteins NLRX1 and TUFM form a complex that regulates type I interferon and autophagy.

Lei Y, Wen H, Yu Y, Taxman DJ, Zhang L, Widman DG, Swanson KV, Wen KW, Damania B, Moore CB, Giguère PM, Siderovski DP, Hiscott J, Razani B, Semenkovich CF, Chen X, Ting JP.

Immunity. 2012 Jun 29;36(6):933-46. doi: 10.1016/j.immuni.2012.03.025.

15.

Enhancer of zeste homolog 2 is a negative regulator of mitochondria-mediated innate immune responses.

Chen S, Sheng C, Liu D, Yao C, Gao S, Song L, Jiang W, Li J, Huang W.

J Immunol. 2013 Sep 1;191(5):2614-23. doi: 10.4049/jimmunol.1203143. Epub 2013 Aug 5.

16.

Mitofusin 2 inhibits mitochondrial antiviral signaling.

Yasukawa K, Oshiumi H, Takeda M, Ishihara N, Yanagi Y, Seya T, Kawabata S, Koshiba T.

Sci Signal. 2009 Aug 18;2(84):ra47. doi: 10.1126/scisignal.2000287.

17.

The DEAH-box RNA helicase DHX15 activates NF-κB and MAPK signaling downstream of MAVS during antiviral responses.

Mosallanejad K, Sekine Y, Ishikura-Kinoshita S, Kumagai K, Nagano T, Matsuzawa A, Takeda K, Naguro I, Ichijo H.

Sci Signal. 2014 Apr 29;7(323):ra40. doi: 10.1126/scisignal.2004841.

PMID:
24782566
18.

GP73 represses host innate immune response to promote virus replication by facilitating MAVS and TRAF6 degradation.

Zhang X, Zhu C, Wang T, Jiang H, Ren Y, Zhang Q, Wu K, Liu F, Liu Y, Wu J.

PLoS Pathog. 2017 Apr 10;13(4):e1006321. doi: 10.1371/journal.ppat.1006321. eCollection 2017 Apr. Erratum in: PLoS Pathog. 2018 Mar 13;14 (3):e1006938.

19.

NLRX1 prevents mitochondrial induced apoptosis and enhances macrophage antiviral immunity by interacting with influenza virus PB1-F2 protein.

Jaworska J, Coulombe F, Downey J, Tzelepis F, Shalaby K, Tattoli I, Berube J, Rousseau S, Martin JG, Girardin SE, McCullers JA, Divangahi M.

Proc Natl Acad Sci U S A. 2014 May 20;111(20):E2110-9. doi: 10.1073/pnas.1322118111. Epub 2014 May 5.

20.

The nucleotide-binding leucine-rich repeat (NLR) family member NLRX1 mediates protection against experimental autoimmune encephalomyelitis and represses macrophage/microglia-induced inflammation.

Eitas TK, Chou WC, Wen H, Gris D, Robbins GR, Brickey J, Oyama Y, Ting JP.

J Biol Chem. 2014 Feb 14;289(7):4173-9. doi: 10.1074/jbc.M113.533034. Epub 2013 Dec 23.

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