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Effect of human activated NRAS on replication of delNS1 H5N1 influenza virus in MDCK cells.

Zhu J, Zhou H, Zou W, Jin M.

Virol J. 2011 May 19;8:240. doi: 10.1186/1743-422X-8-240.


MDCK cell line with inducible allele B NS1 expression propagates delNS1 influenza virus to high titres.

van Wielink R, Harmsen MM, Martens DE, Peeters BP, Wijffels RH, Moormann RJ.

Vaccine. 2011 Sep 16;29(40):6976-85. doi: 10.1016/j.vaccine.2011.07.037. Epub 2011 Jul 23.


An A14U Substitution in the 3' Noncoding Region of the M Segment of Viral RNA Supports Replication of Influenza Virus with an NS1 Deletion by Modulating Alternative Splicing of M Segment mRNAs.

Zheng M, Wang P, Song W, Lau SY, Liu S, Huang X, Mok BW, Liu YC, Chen Y, Yuen KY, Chen H.

J Virol. 2015 Oct;89(20):10273-85. doi: 10.1128/JVI.00919-15. Epub 2015 Jul 29.


Mutations in the M-gene segment can substantially increase replication efficiency of NS1 deletion influenza A virus in MDCK cells.

van Wielink R, Harmsen MM, Martens DE, Peeters BP, Wijffels RH, Moormann RJ.

J Virol. 2012 Nov;86(22):12341-50. doi: 10.1128/JVI.01725-12. Epub 2012 Sep 5.


A genetically engineered influenza A virus with ras-dependent oncolytic properties.

Bergmann M, Romirer I, Sachet M, Fleischhacker R, García-Sastre A, Palese P, Wolff K, Pehamberger H, Jakesz R, Muster T.

Cancer Res. 2001 Nov 15;61(22):8188-93.


Influenza A virus NS1 protein prevents activation of NF-kappaB and induction of alpha/beta interferon.

Wang X, Li M, Zheng H, Muster T, Palese P, Beg AA, García-Sastre A.

J Virol. 2000 Dec;74(24):11566-73.


Effect on virulence and pathogenicity of H5N1 influenza A virus through truncations of NS1 eIF4GI binding domain.

Zhou H, Zhu J, Tu J, Zou W, Hu Y, Yu Z, Yin W, Li Y, Zhang A, Wu Y, Yu Z, Chen H, Jin M.

J Infect Dis. 2010 Nov 1;202(9):1338-46. doi: 10.1086/656536.


The Ebola virus VP35 protein functions as a type I IFN antagonist.

Basler CF, Wang X, Mühlberger E, Volchkov V, Paragas J, Klenk HD, García-Sastre A, Palese P.

Proc Natl Acad Sci U S A. 2000 Oct 24;97(22):12289-94.


Virulence determinants of avian H5N1 influenza A virus in mammalian and avian hosts: role of the C-terminal ESEV motif in the viral NS1 protein.

Zielecki F, Semmler I, Kalthoff D, Voss D, Mauel S, Gruber AD, Beer M, Wolff T.

J Virol. 2010 Oct;84(20):10708-18. doi: 10.1128/JVI.00610-10. Epub 2010 Aug 4.


Effects of influenza A virus NS1 protein on protein expression: the NS1 protein enhances translation and is not required for shutoff of host protein synthesis.

Salvatore M, Basler CF, Parisien JP, Horvath CM, Bourmakina S, Zheng H, Muster T, Palese P, García-Sastre A.

J Virol. 2002 Feb;76(3):1206-12.


Higher titers of some H5N1 and recent human H1N1 and H3N2 influenza viruses in Mv1 Lu vs. MDCK cells.

Hamilton SB, Wyatt DE, Wahlgren BT, O'Dowd MK, Morrissey JM, Daniels DE, Lednicky JA.

Virol J. 2011 Feb 11;8:66. doi: 10.1186/1743-422X-8-66.


Oncolytic effects of a novel influenza A virus expressing interleukin-15 from the NS reading frame.

van Rikxoort M, Michaelis M, Wolschek M, Muster T, Egorov A, Seipelt J, Doerr HW, Cinatl J Jr.

PLoS One. 2012;7(5):e36506. doi: 10.1371/journal.pone.0036506. Epub 2012 May 1.


Activation of interferon regulatory factor 3 is inhibited by the influenza A virus NS1 protein.

Talon J, Horvath CM, Polley R, Basler CF, Muster T, Palese P, García-Sastre A.

J Virol. 2000 Sep;74(17):7989-96.


[Biological significance of amino acids deletion in NA stalk of H5N1 avian influenza virus].

Wang QZ, Long JX, Hu SL, Wu YT, Liu XF.

Wei Sheng Wu Xue Bao. 2006 Aug;46(4):542-6. Chinese.


High yields of influenza A virus in Madin-Darby canine kidney cells are promoted by an insufficient interferon-induced antiviral state.

Seitz C, Frensing T, Höper D, Kochs G, Reichl U.

J Gen Virol. 2010 Jul;91(Pt 7):1754-63. doi: 10.1099/vir.0.020370-0. Epub 2010 Mar 31.


Direct interaction of cellular hnRNP-F and NS1 of influenza A virus accelerates viral replication by modulation of viral transcriptional activity and host gene expression.

Lee JH, Kim SH, Pascua PN, Song MS, Baek YH, Jin X, Choi JK, Kim CJ, Kim H, Choi YK.

Virology. 2010 Feb 5;397(1):89-99. doi: 10.1016/j.virol.2009.10.041. Epub 2009 Nov 18. Retraction in: Virology. 2013 Feb 5;436(1):245.


Growth determinants for H5N1 influenza vaccine seed viruses in MDCK cells.

Murakami S, Horimoto T, Mai le Q, Nidom CA, Chen H, Muramoto Y, Yamada S, Iwasa A, Iwatsuki-Horimoto K, Shimojima M, Iwata A, Kawaoka Y.

J Virol. 2008 Nov;82(21):10502-9. doi: 10.1128/JVI.00970-08. Epub 2008 Sep 3.


Differential susceptibility of different cell lines to swine-origin influenza A H1N1, seasonal human influenza A H1N1, and avian influenza A H5N1 viruses.

Li IW, Chan KH, To KW, Wong SS, Ho PL, Lau SK, Woo PC, Tsoi HW, Chan JF, Cheng VC, Zheng BJ, Chen H, Yuen KY.

J Clin Virol. 2009 Dec;46(4):325-30. doi: 10.1016/j.jcv.2009.09.013. Epub 2009 Oct 3.


A new panel of NS1 antibodies for easy detection and titration of influenza A virus.

Tan Z, Akerstrom S, Wee BY, Lal SK, Mirazimi A, Tan YJ.

J Med Virol. 2010 Mar;82(3):467-75. doi: 10.1002/jmv.21709.


Effective small interfering RNAs targeting matrix and nucleocapsid protein gene inhibit influenza A virus replication in cells and mice.

Zhou H, Jin M, Yu Z, Xu X, Peng Y, Wu H, Liu J, Liu H, Cao S, Chen H.

Antiviral Res. 2007 Nov;76(2):186-93. Epub 2007 Aug 10.


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