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Items: 1 to 20 of 79


Control of Toxoplasma reactivation by rescue of dysfunctional CD8+ T-cell response via PD-1-PDL-1 blockade.

Bhadra R, Gigley JP, Weiss LM, Khan IA.

Proc Natl Acad Sci U S A. 2011 May 31;108(22):9196-201. doi: 10.1073/pnas.1015298108. Epub 2011 May 16.


CD4 T-cell help programs a change in CD8 T-cell function enabling effective long-term control of murine gammaherpesvirus 68: role of PD-1-PD-L1 interactions.

Dias P, Giannoni F, Lee LN, Han D, Yoon S, Yagita H, Azuma M, Sarawar SR.

J Virol. 2010 Aug;84(16):8241-9. doi: 10.1128/JVI.00784-10. Epub 2010 Jun 9.


Donor CD8+ T cells prevent Toxoplasma gondii de-encystation but fail to rescue the exhausted endogenous CD8+ T cell population.

Bhadra R, Cobb DA, Khan IA.

Infect Immun. 2013 Sep;81(9):3414-25. doi: 10.1128/IAI.00784-12. Epub 2013 Jul 1.


Tissue-specific differences in PD-1 and PD-L1 expression during chronic viral infection: implications for CD8 T-cell exhaustion.

Blackburn SD, Crawford A, Shin H, Polley A, Freeman GJ, Wherry EJ.

J Virol. 2010 Feb;84(4):2078-89. doi: 10.1128/JVI.01579-09. Epub 2009 Dec 2.


PD-1-mediated attrition of polyfunctional memory CD8+ T cells in chronic toxoplasma infection.

Bhadra R, Gigley JP, Khan IA.

J Infect Dis. 2012 Jul 1;206(1):125-34. doi: 10.1093/infdis/jis304. Epub 2012 Apr 26.


Premature terminal exhaustion of Friend virus-specific effector CD8+ T cells by rapid induction of multiple inhibitory receptors.

Takamura S, Tsuji-Kawahara S, Yagita H, Akiba H, Sakamoto M, Chikaishi T, Kato M, Miyazawa M.

J Immunol. 2010 May 1;184(9):4696-707. doi: 10.4049/jimmunol.0903478. Epub 2010 Mar 29.


Partial restoration of T-cell function in aged mice by in vitro blockade of the PD-1/ PD-L1 pathway.

Lages CS, Lewkowich I, Sproles A, Wills-Karp M, Chougnet C.

Aging Cell. 2010 Oct;9(5):785-98. doi: 10.1111/j.1474-9726.2010.00611.x.


Selective expansion of a subset of exhausted CD8 T cells by alphaPD-L1 blockade.

Blackburn SD, Shin H, Freeman GJ, Wherry EJ.

Proc Natl Acad Sci U S A. 2008 Sep 30;105(39):15016-21. doi: 10.1073/pnas.0801497105. Epub 2008 Sep 22.


CD8+ T cell immunity in an encephalitis model of Toxoplasma gondii infection.

Hwang S, Khan IA.

Semin Immunopathol. 2015 May;37(3):271-9. doi: 10.1007/s00281-015-0483-7. Epub 2015 May 6. Review.


Analysis of the role of negative T cell costimulatory pathways in CD4 and CD8 T cell-mediated alloimmune responses in vivo.

Ito T, Ueno T, Clarkson MR, Yuan X, Jurewicz MM, Yagita H, Azuma M, Sharpe AH, Auchincloss H Jr, Sayegh MH, Najafian N.

J Immunol. 2005 Jun 1;174(11):6648-56.


Reviving exhausted T lymphocytes during chronic virus infection by B7-H1 blockade.

Yao S, Chen L.

Trends Mol Med. 2006 Jun;12(6):244-6. Epub 2006 May 2.


Restoring function in exhausted CD8 T cells during chronic viral infection.

Barber DL, Wherry EJ, Masopust D, Zhu B, Allison JP, Sharpe AH, Freeman GJ, Ahmed R.

Nature. 2006 Feb 9;439(7077):682-7. Epub 2005 Dec 28.


Forced expression of programmed death-1 gene on T cell decreased the incidence of type 1 diabetes.

Won TJ, Jung YJ, Kwon SJ, Lee YJ, Lee DI, Min H, Park ES, Joo SS, Hwang KW.

Arch Pharm Res. 2010 Nov;33(11):1825-33. doi: 10.1007/s12272-010-1115-3. Epub 2010 Nov 30.


Striking dichotomy of PD-L1 and PD-L2 pathways in regulating alloreactive CD4(+) and CD8(+) T cells in vivo.

Habicht A, Kewalaramani R, Vu MD, Demirci G, Blazar BR, Sayegh MH, Li XC.

Am J Transplant. 2007 Dec;7(12):2683-92. Epub 2007 Oct 9.


Peripheral deletional tolerance of alloreactive CD8 but not CD4 T cells is dependent on the PD-1/PD-L1 pathway.

Haspot F, Fehr T, Gibbons C, Zhao G, Hogan T, Honjo T, Freeman GJ, Sykes M.

Blood. 2008 Sep 1;112(5):2149-55. doi: 10.1182/blood-2007-12-127449. Epub 2008 Jun 24.


Immune CD8(+) T cells prevent reactivation of Toxoplasma gondii infection in the immunocompromised host.

Khan IA, Green WR, Kasper LH, Green KA, Schwartzman JD.

Infect Immun. 1999 Nov;67(11):5869-76.


Rejuvenating exhausted T cells during chronic viral infection.

Okazaki T, Honjo T.

Cell. 2006 Feb 10;124(3):459-61.


A potential new pathway for PD-L1 costimulation of the CD8-T cell response to Listeria monocytogenes infection.

Xu D, Fu HH, Obar JJ, Park JJ, Tamada K, Yagita H, Lefrançois L.

PLoS One. 2013;8(2):e56539. doi: 10.1371/journal.pone.0056539. Epub 2013 Feb 11.

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