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Constitutive mTORC1 activation by a herpesvirus Akt surrogate stimulates mRNA translation and viral replication.

Chuluunbaatar U, Roller R, Feldman ME, Brown S, Shokat KM, Mohr I.

Genes Dev. 2010 Dec 1;24(23):2627-39. doi: 10.1101/gad.1978310.


Herpes Simplex Virus is Akt-ing in translational control.

Norman KL, Sarnow P.

Genes Dev. 2010 Dec 1;24(23):2583-6. doi: 10.1101/gad.2004510.


Herpes simplex virus protein kinases US3 and UL13 modulate VP11/12 phosphorylation, virion packaging, and phosphatidylinositol 3-kinase/Akt signaling activity.

Eaton HE, Saffran HA, Wu FW, Quach K, Smiley JR.

J Virol. 2014 Jul;88(13):7379-88. doi: 10.1128/JVI.00712-14. Epub 2014 Apr 16.


Subversion of Host Responses to Energy Insufficiency by Us3 Supports Herpes Simplex Virus 1 Replication during Stress.

Vink EI, Smiley JR, Mohr I.

J Virol. 2017 Jun 26;91(14). pii: e00295-17. doi: 10.1128/JVI.00295-17. Print 2017 Jul 15.


A herpesvirus kinase that masquerades as Akt: you don't have to look like Akt, to act like it.

Chuluunbaatar U, Mohr I.

Cell Cycle. 2011 Jul 1;10(13):2064-8. Epub 2011 Jul 1.


Phosphorylation of a herpes simplex virus 1 dUTPase by a viral protein kinase, Us3, dictates viral pathogenicity in the central nervous system but not at the periphery.

Kato A, Shindo K, Maruzuru Y, Kawaguchi Y.

J Virol. 2014 Mar;88(5):2775-85. doi: 10.1128/JVI.03300-13. Epub 2013 Dec 18.


Herpes simplex virus 1 protein kinase Us3 and major tegument protein UL47 reciprocally regulate their subcellular localization in infected cells.

Kato A, Liu Z, Minowa A, Imai T, Tanaka M, Sugimoto K, Nishiyama Y, Arii J, Kawaguchi Y.

J Virol. 2011 Sep;85(18):9599-613. doi: 10.1128/JVI.00845-11. Epub 2011 Jul 6.


Growth-factor dependent expression of the translationally controlled tumour protein TCTP is regulated through the PI3-K/Akt/mTORC1 signalling pathway.

Bommer UA, Iadevaia V, Chen J, Knoch B, Engel M, Proud CG.

Cell Signal. 2015 Aug;27(8):1557-68. doi: 10.1016/j.cellsig.2015.04.011. Epub 2015 Apr 30.


Characterization of a Herpes Simplex Virus 1 (HSV-1) Chimera in Which the Us3 Protein Kinase Gene Is Replaced with the HSV-2 Us3 Gene.

Shindo K, Kato A, Koyanagi N, Sagara H, Arii J, Kawaguchi Y.

J Virol. 2015 Oct 21;90(1):457-73. doi: 10.1128/JVI.02376-15. Print 2016 Jan 1.


The human papillomavirus type 16 E6 oncoprotein activates mTORC1 signaling and increases protein synthesis.

Spangle JM, M√ľnger K.

J Virol. 2010 Sep;84(18):9398-407. doi: 10.1128/JVI.00974-10. Epub 2010 Jul 14.


Us3 kinase encoded by herpes simplex virus 1 mediates downregulation of cell surface major histocompatibility complex class I and evasion of CD8+ T cells.

Imai T, Koyanagi N, Ogawa R, Shindo K, Suenaga T, Sato A, Arii J, Kato A, Kiyono H, Arase H, Kawaguchi Y.

PLoS One. 2013 Aug 12;8(8):e72050. doi: 10.1371/journal.pone.0072050. eCollection 2013.


Role for the phosphatidylinositol 3-kinase-Akt-TOR pathway during sindbis virus replication in arthropods.

Patel RK, Hardy RW.

J Virol. 2012 Apr;86(7):3595-604. doi: 10.1128/JVI.06625-11. Epub 2012 Jan 18.


Herpes simplex virus 1 protein kinase Us3 phosphorylates viral envelope glycoprotein B and regulates its expression on the cell surface.

Kato A, Arii J, Shiratori I, Akashi H, Arase H, Kawaguchi Y.

J Virol. 2009 Jan;83(1):250-61. doi: 10.1128/JVI.01451-08. Epub 2008 Oct 22.


Herpes simplex virus 1 serine/threonine kinase US3 hyperphosphorylates IRF3 and inhibits beta interferon production.

Wang S, Wang K, Lin R, Zheng C.

J Virol. 2013 Dec;87(23):12814-27. doi: 10.1128/JVI.02355-13. Epub 2013 Sep 18.


Rapamycin-resistant mTORC1 kinase activity is required for herpesvirus replication.

Moorman NJ, Shenk T.

J Virol. 2010 May;84(10):5260-9. doi: 10.1128/JVI.02733-09. Epub 2010 Feb 24.


ERK and AKT signaling cooperate to translationally regulate survivin expression for metastatic progression of colorectal cancer.

Ye Q, Cai W, Zheng Y, Evers BM, She QB.

Oncogene. 2014 Apr 3;33(14):1828-39. doi: 10.1038/onc.2013.122. Epub 2013 Apr 29.


Constitutive phosphorylation of the mTORC2/Akt/4E-BP1 pathway in newly derived canine hemangiosarcoma cell lines.

Murai A, Asa SA, Kodama A, Hirata A, Yanai T, Sakai H.

BMC Vet Res. 2012 Jul 29;8:128. doi: 10.1186/1746-6148-8-128.

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