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Hepatitis C virus inhibits DNA damage repair through reactive oxygen and nitrogen species and by interfering with the ATM-NBS1/Mre11/Rad50 DNA repair pathway in monocytes and hepatocytes.

Machida K, McNamara G, Cheng KT, Huang J, Wang CH, Comai L, Ou JH, Lai MM.

J Immunol. 2010 Dec 1;185(11):6985-98. doi: 10.4049/jimmunol.1000618. Epub 2010 Oct 25.


Ataxia telangiectasia-mutated (ATM) kinase activity is regulated by ATP-driven conformational changes in the Mre11/Rad50/Nbs1 (MRN) complex.

Lee JH, Mand MR, Deshpande RA, Kinoshita E, Yang SH, Wyman C, Paull TT.

J Biol Chem. 2013 May 3;288(18):12840-51. doi: 10.1074/jbc.M113.460378. Epub 2013 Mar 22.


Defective Mre11-dependent activation of Chk2 by ataxia telangiectasia mutated in colorectal carcinoma cells in response to replication-dependent DNA double strand breaks.

Takemura H, Rao VA, Sordet O, Furuta T, Miao ZH, Meng L, Zhang H, Pommier Y.

J Biol Chem. 2006 Oct 13;281(41):30814-23. Epub 2006 Aug 10.


ATM and the Mre11-Rad50-Nbs1 complex respond to nucleoside analogue-induced stalled replication forks and contribute to drug resistance.

Ewald B, Sampath D, Plunkett W.

Cancer Res. 2008 Oct 1;68(19):7947-55. doi: 10.1158/0008-5472.CAN-08-0971.


Characterization of an NBS1 C-terminal peptide that can inhibit ataxia telangiectasia mutated (ATM)-mediated DNA damage responses and enhance radiosensitivity.

Cariveau MJ, Tang X, Cui XL, Xu B.

Mol Pharmacol. 2007 Aug;72(2):320-6. Epub 2007 May 16. Erratum in: Mol Pharmacol. 2011 Nov;80(5):953.


The Mre11/Rad50/Nbs1 complex and its role as a DNA double-strand break sensor for ATM.

Paull TT, Lee JH.

Cell Cycle. 2005 Jun;4(6):737-40. Epub 2005 Jun 6.


Activation of ataxia telangiectasia-mutated DNA damage checkpoint signal transduction elicited by herpes simplex virus infection.

Shirata N, Kudoh A, Daikoku T, Tatsumi Y, Fujita M, Kiyono T, Sugaya Y, Isomura H, Ishizaki K, Tsurumi T.

J Biol Chem. 2005 Aug 26;280(34):30336-41. Epub 2005 Jun 17.


Artemis and nonhomologous end joining-independent influence of DNA-dependent protein kinase catalytic subunit on chromosome stability.

Stracker TH, Williams BR, Deriano L, Theunissen JW, Adelman CA, Roth DB, Petrini JH.

Mol Cell Biol. 2009 Jan;29(2):503-14. doi: 10.1128/MCB.01354-08. Epub 2008 Nov 17.


The Rad50S allele promotes ATM-dependent DNA damage responses and suppresses ATM deficiency: implications for the Mre11 complex as a DNA damage sensor.

Morales M, Theunissen JW, Kim CF, Kitagawa R, Kastan MB, Petrini JH.

Genes Dev. 2005 Dec 15;19(24):3043-54.


Selenium compounds activate ATM-dependent DNA damage response via the mismatch repair protein hMLH1 in colorectal cancer cells.

Qi Y, Schoene NW, Lartey FM, Cheng WH.

J Biol Chem. 2010 Oct 22;285(43):33010-7. doi: 10.1074/jbc.M110.137406. Epub 2010 Aug 6.


ATM protein-dependent phosphorylation of Rad50 protein regulates DNA repair and cell cycle control.

Gatei M, Jakob B, Chen P, Kijas AW, Becherel OJ, Gueven N, Birrell G, Lee JH, Paull TT, Lerenthal Y, Fazry S, Taucher-Scholz G, Kalb R, Schindler D, Waltes R, Dörk T, Lavin MF.

J Biol Chem. 2011 Sep 9;286(36):31542-56. doi: 10.1074/jbc.M111.258152. Epub 2011 Jul 14.


Role of Nbs1 in the activation of the Atm kinase revealed in humanized mouse models.

Difilippantonio S, Celeste A, Fernandez-Capetillo O, Chen HT, Reina San Martin B, Van Laethem F, Yang YP, Petukhova GV, Eckhaus M, Feigenbaum L, Manova K, Kruhlak M, Camerini-Otero RD, Sharan S, Nussenzweig M, Nussenzweig A.

Nat Cell Biol. 2005 Jul;7(7):675-85. Epub 2005 Jun 19.


Role of mammalian Mre11 in classical and alternative nonhomologous end joining.

Xie A, Kwok A, Scully R.

Nat Struct Mol Biol. 2009 Aug;16(8):814-8. doi: 10.1038/nsmb.1640. Epub 2009 Jul 26.


Differential DNA damage signaling accounts for distinct neural apoptotic responses in ATLD and NBS.

Shull ER, Lee Y, Nakane H, Stracker TH, Zhao J, Russell HR, Petrini JH, McKinnon PJ.

Genes Dev. 2009 Jan 15;23(2):171-80. doi: 10.1101/gad.1746609.


Autophosphorylation and ATM activation: additional sites add to the complexity.

Kozlov SV, Graham ME, Jakob B, Tobias F, Kijas AW, Tanuji M, Chen P, Robinson PJ, Taucher-Scholz G, Suzuki K, So S, Chen D, Lavin MF.

J Biol Chem. 2011 Mar 18;286(11):9107-19. doi: 10.1074/jbc.M110.204065. Epub 2010 Dec 13.


Role of Mre11 in chromosomal nonhomologous end joining in mammalian cells.

Rass E, Grabarz A, Plo I, Gautier J, Bertrand P, Lopez BS.

Nat Struct Mol Biol. 2009 Aug;16(8):819-24. doi: 10.1038/nsmb.1641. Epub 2009 Jul 26.


NBS1 regulates a novel apoptotic pathway through Bax activation.

Iijima K, Muranaka C, Kobayashi J, Sakamoto S, Komatsu K, Matsuura S, Kubota N, Tauchi H.

DNA Repair (Amst). 2008 Oct 1;7(10):1705-16. doi: 10.1016/j.dnarep.2008.06.013. Epub 2008 Jul 31.


ATM activation by oxidative stress.

Guo Z, Kozlov S, Lavin MF, Person MD, Paull TT.

Science. 2010 Oct 22;330(6003):517-21. doi: 10.1126/science.1192912.


ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex.

Lee JH, Paull TT.

Science. 2005 Apr 22;308(5721):551-4. Epub 2005 Mar 24. Erratum in: Science. 2005 Jun 24;308(5730):1870.

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