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Phosphoinositide 3 kinase signalling may affect multiple steps during herpes simplex virus type-1 entry.

Tiwari V, Shukla D.

J Gen Virol. 2010 Dec;91(Pt 12):3002-9. doi: 10.1099/vir.0.024166-0. Epub 2010 Sep 1.


A Functional Interaction between Herpes Simplex Virus 1 Glycoprotein gH/gL Domains I and II and gD Is Defined by Using Alphaherpesvirus gH and gL Chimeras.

Fan Q, Longnecker R, Connolly SA.

J Virol. 2015 Jul;89(14):7159-69. doi: 10.1128/JVI.00740-15. Epub 2015 Apr 29.


Novel mutations in gB and gH circumvent the requirement for known gD Receptors in herpes simplex virus 1 entry and cell-to-cell spread.

Uchida H, Chan J, Shrivastava I, Reinhart B, Grandi P, Glorioso JC, Cohen JB.

J Virol. 2013 Feb;87(3):1430-42. doi: 10.1128/JVI.02804-12. Epub 2012 Nov 14.


Epidermal growth factor receptor-PI3K signaling controls cofilin activity to facilitate herpes simplex virus 1 entry into neuronal cells.

Zheng K, Xiang Y, Wang X, Wang Q, Zhong M, Wang S, Wang X, Fan J, Kitazato K, Wang Y.

MBio. 2014 Jan 14;5(1):e00958-13. doi: 10.1128/mBio.00958-13.


Regulation of herpes simplex virus gB-induced cell-cell fusion by mutant forms of gH/gL in the absence of gD and cellular receptors.

Atanasiu D, Cairns TM, Whitbeck JC, Saw WT, Rao S, Eisenberg RJ, Cohen GH.

MBio. 2013 Feb 26;4(2). pii: e00046-13. doi: 10.1128/mBio.00046-13.


Reevaluating herpes simplex virus hemifusion.

Jackson JO, Longnecker R.

J Virol. 2010 Nov;84(22):11814-21. doi: 10.1128/JVI.01615-10. Epub 2010 Sep 15.


Non-muscle myosin IIA is a functional entry receptor for herpes simplex virus-1.

Arii J, Goto H, Suenaga T, Oyama M, Kozuka-Hata H, Imai T, Minowa A, Akashi H, Arase H, Kawaoka Y, Kawaguchi Y.

Nature. 2010 Oct 14;467(7317):859-62. doi: 10.1038/nature09420.


Dissociation of HSV gL from gH by αvβ6- or αvβ8-integrin promotes gH activation and virus entry.

Gianni T, Massaro R, Campadelli-Fiume G.

Proc Natl Acad Sci U S A. 2015 Jul 21;112(29):E3901-10. doi: 10.1073/pnas.1506846112. Epub 2015 Jul 8.


Fusion between perinuclear virions and the outer nuclear membrane requires the fusogenic activity of herpes simplex virus gB.

Wright CC, Wisner TW, Hannah BP, Eisenberg RJ, Cohen GH, Johnson DC.

J Virol. 2009 Nov;83(22):11847-56. doi: 10.1128/JVI.01397-09. Epub 2009 Sep 16.


Contortrostatin, a homodimeric disintegrin isolated from snake venom inhibits herpes simplex virus entry and cell fusion.

Hubbard S, Choudhary S, Maus E, Shukla D, Swenson S, Markland FS Jr, Tiwari V.

Antivir Ther. 2012;17(7):1319-26. doi: 10.3851/IMP2291. Epub 2012 Aug 8.


CD40 ligand exhibits a direct antiviral effect on Herpes Simplex Virus type-1 infection via a PI3K-dependent, autophagy-independent mechanism.

Vlahava VM, Eliopoulos AG, Sourvinos G.

Cell Signal. 2015 Jun;27(6):1253-63. doi: 10.1016/j.cellsig.2015.03.002. Epub 2015 Mar 10.


A sugar binding protein cyanovirin-N blocks herpes simplex virus type-1 entry and cell fusion.

Tiwari V, Shukla SY, Shukla D.

Antiviral Res. 2009 Oct;84(1):67-75. doi: 10.1016/j.antiviral.2009.07.014. Epub 2009 Aug 7.


Herpes B virus utilizes human nectin-1 but not HVEM or PILRα for cell-cell fusion and virus entry.

Fan Q, Amen M, Harden M, Severini A, Griffiths A, Longnecker R.

J Virol. 2012 Apr;86(8):4468-76. doi: 10.1128/JVI.00041-12. Epub 2012 Feb 15.


Herpes simplex virus internalization into epithelial cells requires Na+/H+ exchangers and p21-activated kinases but neither clathrin- nor caveolin-mediated endocytosis.

Devadas D, Koithan T, Diestel R, Prank U, Sodeik B, Döhner K.

J Virol. 2014 Nov;88(22):13378-95. doi: 10.1128/JVI.03631-13. Epub 2014 Sep 10.


Role for 3-O-sulfated heparan sulfate as the receptor for herpes simplex virus type 1 entry into primary human corneal fibroblasts.

Tiwari V, Clement C, Xu D, Valyi-Nagy T, Yue BY, Liu J, Shukla D.

J Virol. 2006 Sep;80(18):8970-80.


Inhibition of myosin light chain kinase can be targeted for the development of new therapies against herpes simplex virus type-1 infection.

Antoine TE, Shukla D.

Antivir Ther. 2014;19(1):15-29. doi: 10.3851/IMP2661. Epub 2013 Jun 28.


Cross talk among the glycoproteins involved in herpes simplex virus entry and fusion: the interaction between gB and gH/gL does not necessarily require gD.

Avitabile E, Forghieri C, Campadelli-Fiume G.

J Virol. 2009 Oct;83(20):10752-60. doi: 10.1128/JVI.01287-09. Epub 2009 Aug 5.

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