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Items: 1 to 20 of 122

1.

TMPRSS2 and TMPRSS4 facilitate trypsin-independent spread of influenza virus in Caco-2 cells.

Bertram S, Glowacka I, Blazejewska P, Soilleux E, Allen P, Danisch S, Steffen I, Choi SY, Park Y, Schneider H, Schughart K, Pöhlmann S.

J Virol. 2010 Oct;84(19):10016-25. doi: 10.1128/JVI.00239-10. Epub 2010 Jul 14.

2.

The Proteolytic Activation of (H3N2) Influenza A Virus Hemagglutinin Is Facilitated by Different Type II Transmembrane Serine Proteases.

Kühn N, Bergmann S, Kösterke N, Lambertz RLO, Keppner A, van den Brand JMA, Pöhlmann S, Weiß S, Hummler E, Hatesuer B, Schughart K.

J Virol. 2016 Apr 14;90(9):4298-4307. doi: 10.1128/JVI.02693-15. Print 2016 May.

3.

TMPRSS2 and MSPL Facilitate Trypsin-Independent Porcine Epidemic Diarrhea Virus Replication in Vero Cells.

Shi W, Fan W, Bai J, Tang Y, Wang L, Jiang Y, Tang L, Liu M, Cui W, Xu Y, Li Y.

Viruses. 2017 May 18;9(5). pii: E114. doi: 10.3390/v9050114.

4.

Proteolytic activation of the 1918 influenza virus hemagglutinin.

Chaipan C, Kobasa D, Bertram S, Glowacka I, Steffen I, Tsegaye TS, Takeda M, Bugge TH, Kim S, Park Y, Marzi A, Pöhlmann S.

J Virol. 2009 Apr;83(7):3200-11. doi: 10.1128/JVI.02205-08. Epub 2009 Jan 21.

5.

MDCK cells that express proteases TMPRSS2 and HAT provide a cell system to propagate influenza viruses in the absence of trypsin and to study cleavage of HA and its inhibition.

Böttcher E, Freuer C, Steinmetzer T, Klenk HD, Garten W.

Vaccine. 2009 Oct 23;27(45):6324-9. doi: 10.1016/j.vaccine.2009.03.029.

PMID:
19840668
6.

The host protease TMPRSS2 plays a major role in in vivo replication of emerging H7N9 and seasonal influenza viruses.

Sakai K, Ami Y, Tahara M, Kubota T, Anraku M, Abe M, Nakajima N, Sekizuka T, Shirato K, Suzaki Y, Ainai A, Nakatsu Y, Kanou K, Nakamura K, Suzuki T, Komase K, Nobusawa E, Maenaka K, Kuroda M, Hasegawa H, Kawaoka Y, Tashiro M, Takeda M.

J Virol. 2014 May;88(10):5608-16. doi: 10.1128/JVI.03677-13. Epub 2014 Mar 5.

7.

Matriptase proteolytically activates influenza virus and promotes multicycle replication in the human airway epithelium.

Beaulieu A, Gravel É, Cloutier A, Marois I, Colombo É, Désilets A, Verreault C, Leduc R, Marsault É, Richter MV.

J Virol. 2013 Apr;87(8):4237-51. doi: 10.1128/JVI.03005-12. Epub 2013 Jan 30.

8.

Novel insights into proteolytic cleavage of influenza virus hemagglutinin.

Bertram S, Glowacka I, Steffen I, Kühl A, Pöhlmann S.

Rev Med Virol. 2010 Sep;20(5):298-310. doi: 10.1002/rmv.657. Review.

PMID:
20629046
9.

Influenza and SARS-coronavirus activating proteases TMPRSS2 and HAT are expressed at multiple sites in human respiratory and gastrointestinal tracts.

Bertram S, Heurich A, Lavender H, Gierer S, Danisch S, Perin P, Lucas JM, Nelson PS, Pöhlmann S, Soilleux EJ.

PLoS One. 2012;7(4):e35876. doi: 10.1371/journal.pone.0035876. Epub 2012 Apr 30.

10.

Cleavage of influenza virus hemagglutinin by airway proteases TMPRSS2 and HAT differs in subcellular localization and susceptibility to protease inhibitors.

Böttcher-Friebertshäuser E, Freuer C, Sielaff F, Schmidt S, Eickmann M, Uhlendorff J, Steinmetzer T, Klenk HD, Garten W.

J Virol. 2010 Jun;84(11):5605-14. doi: 10.1128/JVI.00140-10. Epub 2010 Mar 17.

11.

Influenza virus activating host proteases: Identification, localization and inhibitors as potential therapeutics.

Garten W, Braden C, Arendt A, Peitsch C, Baron J, Lu Y, Pawletko K, Hardes K, Steinmetzer T, Böttcher-Friebertshäuser E.

Eur J Cell Biol. 2015 Jul-Sep;94(7-9):375-83. doi: 10.1016/j.ejcb.2015.05.013. Epub 2015 Jun 1.

PMID:
26095298
12.

TMPRSS2 is a host factor that is essential for pneumotropism and pathogenicity of H7N9 influenza A virus in mice.

Tarnow C, Engels G, Arendt A, Schwalm F, Sediri H, Preuss A, Nelson PS, Garten W, Klenk HD, Gabriel G, Böttcher-Friebertshäuser E.

J Virol. 2014 May;88(9):4744-51. doi: 10.1128/JVI.03799-13. Epub 2014 Feb 12.

13.

Inhibition of influenza virus infection in human airway cell cultures by an antisense peptide-conjugated morpholino oligomer targeting the hemagglutinin-activating protease TMPRSS2.

Böttcher-Friebertshäuser E, Stein DA, Klenk HD, Garten W.

J Virol. 2011 Feb;85(4):1554-62. doi: 10.1128/JVI.01294-10. Epub 2010 Dec 1.

14.

Non-human primate orthologues of TMPRSS2 cleave and activate the influenza virus hemagglutinin.

Zmora P, Molau-Blazejewska P, Bertram S, Walendy-Gnirß K, Nehlmeier I, Hartleib A, Moldenhauer AS, Konzok S, Dehmel S, Sewald K, Brinkmann C, Curths C, Knauf S, Gruber J, Mätz-Rensing K, Dahlmann F, Braun A, Pöhlmann S.

PLoS One. 2017 May 11;12(5):e0176597. doi: 10.1371/journal.pone.0176597. eCollection 2017.

15.

Proteolytic activation of influenza viruses by serine proteases TMPRSS2 and HAT from human airway epithelium.

Böttcher E, Matrosovich T, Beyerle M, Klenk HD, Garten W, Matrosovich M.

J Virol. 2006 Oct;80(19):9896-8.

16.

Activation of influenza viruses by proteases from host cells and bacteria in the human airway epithelium.

Böttcher-Friebertshäuser E, Klenk HD, Garten W.

Pathog Dis. 2013 Nov;69(2):87-100. doi: 10.1111/2049-632X.12053. Epub 2013 Jul 2. Review.

PMID:
23821437
17.

DESC1 and MSPL activate influenza A viruses and emerging coronaviruses for host cell entry.

Zmora P, Blazejewska P, Moldenhauer AS, Welsch K, Nehlmeier I, Wu Q, Schneider H, Pöhlmann S, Bertram S.

J Virol. 2014 Oct;88(20):12087-97. doi: 10.1128/JVI.01427-14. Epub 2014 Aug 13.

18.

TMPRSS2 Isoform 1 Activates Respiratory Viruses and Is Expressed in Viral Target Cells.

Zmora P, Moldenhauer AS, Hofmann-Winkler H, Pöhlmann S.

PLoS One. 2015 Sep 17;10(9):e0138380. doi: 10.1371/journal.pone.0138380. eCollection 2015.

19.

Tmprss2 is essential for influenza H1N1 virus pathogenesis in mice.

Hatesuer B, Bertram S, Mehnert N, Bahgat MM, Nelson PS, Pöhlmann S, Schughart K.

PLoS Pathog. 2013;9(12):e1003774. doi: 10.1371/journal.ppat.1003774. Epub 2013 Dec 5. Erratum in: PLoS Pathog. 2014 Sep;10(9):e1004435. Pöhlman, Stefan [corrected to Pöhlmann, Stefan].

20.

The serine protease inhibitor camostat inhibits influenza virus replication and cytokine production in primary cultures of human tracheal epithelial cells.

Yamaya M, Shimotai Y, Hatachi Y, Lusamba Kalonji N, Tando Y, Kitajima Y, Matsuo K, Kubo H, Nagatomi R, Hongo S, Homma M, Nishimura H.

Pulm Pharmacol Ther. 2015 Aug;33:66-74. doi: 10.1016/j.pupt.2015.07.001. Epub 2015 Jul 10.

PMID:
26166259

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