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Items: 1 to 20 of 210

1.

Toxoplasma gondii activates hypoxia-inducible factor (HIF) by stabilizing the HIF-1alpha subunit via type I activin-like receptor kinase receptor signaling.

Wiley M, Sweeney KR, Chan DA, Brown KM, McMurtrey C, Howard EW, Giaccia AJ, Blader IJ.

J Biol Chem. 2010 Aug 27;285(35):26852-60. doi: 10.1074/jbc.M110.147041. Epub 2010 Jun 25.

2.

Src activates HIF-1α not through direct phosphorylation of HIF-1α specific prolyl-4 hydroxylase 2 but through activation of the NADPH oxidase/Rac pathway.

Lee HY, Lee T, Lee N, Yang EG, Lee C, Lee J, Moon EY, Ha J, Park H.

Carcinogenesis. 2011 May;32(5):703-12. doi: 10.1093/carcin/bgr034. Epub 2011 Feb 18.

PMID:
21335603
3.

Hypoxia-inducible factor-1 (HIF-1) promotes its degradation by induction of HIF-alpha-prolyl-4-hydroxylases.

Marxsen JH, Stengel P, Doege K, Heikkinen P, Jokilehto T, Wagner T, Jelkmann W, Jaakkola P, Metzen E.

Biochem J. 2004 Aug 1;381(Pt 3):761-7.

4.

Nitric oxide modulates oxygen sensing by hypoxia-inducible factor 1-dependent induction of prolyl hydroxylase 2.

Berchner-Pfannschmidt U, Yamac H, Trinidad B, Fandrey J.

J Biol Chem. 2007 Jan 19;282(3):1788-96. Epub 2006 Oct 23.

5.

Endothelin-1 inhibits prolyl hydroxylase domain 2 to activate hypoxia-inducible factor-1alpha in melanoma cells.

Spinella F, Rosanò L, Del Duca M, Di Castro V, Nicotra MR, Natali PG, Bagnato A.

PLoS One. 2010 Jun 21;5(6):e11241. doi: 10.1371/journal.pone.0011241.

6.
7.

HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1alpha in normoxia.

Berra E, Benizri E, Ginouvès A, Volmat V, Roux D, Pouysségur J.

EMBO J. 2003 Aug 15;22(16):4082-90.

8.
9.

The LIMD1 protein bridges an association between the prolyl hydroxylases and VHL to repress HIF-1 activity.

Foxler DE, Bridge KS, James V, Webb TM, Mee M, Wong SC, Feng Y, Constantin-Teodosiu D, Petursdottir TE, Bjornsson J, Ingvarsson S, Ratcliffe PJ, Longmore GD, Sharp TV.

Nat Cell Biol. 2012 Jan 29;14(2):201-8. doi: 10.1038/ncb2424.

PMID:
22286099
10.

Oxygen sensing by the prolyl-4-hydroxylase PHD2 within the nuclear compartment and the influence of compartmentalisation on HIF-1 signalling.

Pientka FK, Hu J, Schindler SG, Brix B, Thiel A, Jöhren O, Fandrey J, Berchner-Pfannschmidt U, Depping R.

J Cell Sci. 2012 Nov 1;125(Pt 21):5168-76. doi: 10.1242/jcs.109041. Epub 2012 Sep 3.

11.

Identification of an alternative mechanism of degradation of the hypoxia-inducible factor-1alpha.

André H, Pereira TS.

J Biol Chem. 2008 Oct 24;283(43):29375-84. doi: 10.1074/jbc.M805919200. Epub 2008 Aug 11.

12.

OS-9 interacts with hypoxia-inducible factor 1alpha and prolyl hydroxylases to promote oxygen-dependent degradation of HIF-1alpha.

Baek JH, Mahon PC, Oh J, Kelly B, Krishnamachary B, Pearson M, Chan DA, Giaccia AJ, Semenza GL.

Mol Cell. 2005 Feb 18;17(4):503-12.

13.
14.

Stabilization of hypoxia-inducible factor-1alpha protein in hypoxia occurs independently of mitochondrial reactive oxygen species production.

Chua YL, Dufour E, Dassa EP, Rustin P, Jacobs HT, Taylor CT, Hagen T.

J Biol Chem. 2010 Oct 8;285(41):31277-84. doi: 10.1074/jbc.M110.158485. Epub 2010 Jul 30.

15.
16.

HIF-1α and HIF-2α degradation is differentially regulated in nucleus pulposus cells of the intervertebral disc.

Fujita N, Chiba K, Shapiro IM, Risbud MV.

J Bone Miner Res. 2012 Feb;27(2):401-12. doi: 10.1002/jbmr.538.

17.

Prolyl hydroxylase domain 2 deficiency promotes skeletal muscle fiber-type transition via a calcineurin/NFATc1-dependent pathway.

Shin J, Nunomiya A, Kitajima Y, Dan T, Miyata T, Nagatomi R.

Skelet Muscle. 2016 Mar 5;6:5. doi: 10.1186/s13395-016-0079-5. eCollection 2016.

18.

Leu-574 of human HIF-1alpha is a molecular determinant of prolyl hydroxylation.

Kageyama Y, Koshiji M, To KK, Tian YM, Ratcliffe PJ, Huang LE.

FASEB J. 2004 Jun;18(9):1028-30. Epub 2004 Apr 14.

PMID:
15084514
19.

Hypoxia-inducible factors in the first trimester human lung.

Groenman F, Rutter M, Caniggia I, Tibboel D, Post M.

J Histochem Cytochem. 2007 Apr;55(4):355-63. Epub 2006 Dec 22.

PMID:
17189520
20.

Differential function of the prolyl hydroxylases PHD1, PHD2, and PHD3 in the regulation of hypoxia-inducible factor.

Appelhoff RJ, Tian YM, Raval RR, Turley H, Harris AL, Pugh CW, Ratcliffe PJ, Gleadle JM.

J Biol Chem. 2004 Sep 10;279(37):38458-65. Epub 2004 Jul 7.

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