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A role for the mevalonate pathway in the induction of subtype cross-reactive immunity to influenza A virus by human gammadelta T lymphocytes.

Jameson JM, Cruz J, Costanzo A, Terajima M, Ennis FA.

Cell Immunol. 2010;264(1):71-7. doi: 10.1016/j.cellimm.2010.04.013. Epub 2010 May 4.


Statins prevent bisphosphonate-induced gamma,delta-T-cell proliferation and activation in vitro.

Thompson K, Rogers MJ.

J Bone Miner Res. 2004 Feb;19(2):278-88. Epub 2003 Dec 16.


Expansion of human peripheral blood γδ T cells using zoledronate.

Kondo M, Izumi T, Fujieda N, Kondo A, Morishita T, Matsushita H, Kakimi K.

J Vis Exp. 2011 Sep 9;(55). pii: 3182. doi: 10.3791/3182.


Constant TCR triggering suggests that the TCR expressed on intestinal intraepithelial γδ T cells is functional in vivo.

Malinarich FH, Grabski E, Worbs T, Chennupati V, Haas JD, Schmitz S, Candia E, Quera R, Malissen B, Förster R, Hermoso M, Prinz I.

Eur J Immunol. 2010 Dec;40(12):3378-88. doi: 10.1002/eji.201040727. Epub 2010 Nov 11.


Small molecules for the activation of human gammadelta T cell responses against infection.

Kabelitz D.

Recent Pat Antiinfect Drug Discov. 2008 Jan;3(1):1-9. Review.


Effect of HMG-CoA reductase inhibitors on activation of human gammadeltaT cells induced by Mycobacterium tuberculosis antigens.

Lü HZ, Li BQ.

Immunopharmacol Immunotoxicol. 2009;31(3):485-91. doi: 10.1080/08923970902806505.


CD94/NKG2 inhibitory receptor complex modulates both anti-viral and anti-tumoral responses of polyclonal phosphoantigen-reactive V gamma 9V delta 2 T lymphocytes.

Poccia F, Cipriani B, Vendetti S, Colizzi V, Poquet Y, Battistini L, López-Botet M, Fournié JJ, Gougeon ML.

J Immunol. 1997 Dec 15;159(12):6009-17.


Highly active microbial phosphoantigen induces rapid yet sustained MEK/Erk- and PI-3K/Akt-mediated signal transduction in anti-tumor human gammadelta T-cells.

Correia DV, d'Orey F, Cardoso BA, Lança T, Grosso AR, deBarros A, Martins LR, Barata JT, Silva-Santos B.

PLoS One. 2009 May 21;4(5):e5657. doi: 10.1371/journal.pone.0005657.


γδ T Cells Contribute to the Outcome of Murine Fulminant Viral Hepatitis via Effector Cytokines TNF-α and IFN-γ.

Wu D, Yan WM, Wang HW, Huang D, Luo XP, Ning Q.

Curr Med Sci. 2018 Aug;38(4):648-655. doi: 10.1007/s11596-018-1926-x. Epub 2018 Aug 20.


Reduced activation and proliferation of human lymphocytes exposed to respiratory syncytial virus compared to cells exposed to influenza virus.

Fleming EH, Ochoa EE, Nichols JE, O'Banion MK, Salkind AR, Roberts NJ Jr.

J Med Virol. 2018 Jan;90(1):26-33. doi: 10.1002/jmv.24917. Epub 2017 Sep 26.


Changes in cytokine levels and NK cell activation associated with influenza.

Jost S, Quillay H, Reardon J, Peterson E, Simmons RP, Parry BA, Bryant NN, Binder WD, Altfeld M.

PLoS One. 2011;6(9):e25060. doi: 10.1371/journal.pone.0025060. Epub 2011 Sep 23.


Dysregulation of the host mevalonate pathway during early bacterial infection activates human TCR gamma delta cells.

Kistowska M, Rossy E, Sansano S, Gober HJ, Landmann R, Mori L, De Libero G.

Eur J Immunol. 2008 Aug;38(8):2200-9. doi: 10.1002/eji.200838366.


Reduced expression of the mevalonate pathway enzyme farnesyl pyrophosphate synthase unveils recognition of tumor cells by Vgamma9Vdelta2 T cells.

Li J, Herold MJ, Kimmel B, Müller I, Rincon-Orozco B, Kunzmann V, Herrmann T.

J Immunol. 2009 Jun 15;182(12):8118-24. doi: 10.4049/jimmunol.0900101.


The interaction of influenza H5N1 viral hemagglutinin with sialic acid receptors leads to the activation of human γδ T cells.

Lu Y, Li Z, Ma C, Wang H, Zheng J, Cui L, He W.

Cell Mol Immunol. 2013 Nov;10(6):463-70. doi: 10.1038/cmi.2013.26. Epub 2013 Aug 5.


Phosphoantigen-expanded human gammadelta T cells display potent cytotoxicity against monocyte-derived macrophages infected with human and avian influenza viruses.

Qin G, Mao H, Zheng J, Sia SF, Liu Y, Chan PL, Lam KT, Peiris JS, Lau YL, Tu W.

J Infect Dis. 2009 Sep 15;200(6):858-65. doi: 10.1086/605413.


Alkylamines cause Vgamma9Vdelta2 T-cell activation and proliferation by inhibiting the mevalonate pathway.

Thompson K, Rojas-Navea J, Rogers MJ.

Blood. 2006 Jan 15;107(2):651-4. Epub 2005 Sep 22.


Impaired T-cell receptor activation in IL-1 receptor-associated kinase-4-deficient patients.

McDonald DR, Goldman F, Gomez-Duarte OD, Issekutz AC, Kumararatne DS, Doffinger R, Geha RS.

J Allergy Clin Immunol. 2010 Aug;126(2):332-7, 337.e1-2. doi: 10.1016/j.jaci.2010.05.013.


Type 1 responses of human Vγ9Vδ2 T cells to influenza A viruses.

Qin G, Liu Y, Zheng J, Ng IH, Xiang Z, Lam KT, Mao H, Li H, Peiris JS, Lau YL, Tu W.

J Virol. 2011 Oct;85(19):10109-16. doi: 10.1128/JVI.05341-11. Epub 2011 Jul 13.


Rapid and transient activation of γδ T cells to IFN-γ production, NK cell-like killing, and antigen processing during acute virus infection.

Toka FN, Kenney MA, Golde WT.

J Immunol. 2011 Apr 15;186(8):4853-61. doi: 10.4049/jimmunol.1003599. Epub 2011 Mar 7.

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