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Items: 1 to 20 of 224

1.

Nonstructural 5A protein activates beta-catenin signaling cascades: implication of hepatitis C virus-induced liver pathogenesis.

Park CY, Choi SH, Kang SM, Kang JI, Ahn BY, Kim H, Jung G, Choi KY, Hwang SB.

J Hepatol. 2009 Nov;51(5):853-64. doi: 10.1016/j.jhep.2009.06.026. Epub 2009 Aug 12.

PMID:
19726098
2.
3.

Hepatitis C virus NS5A promotes insulin resistance through IRS-1 serine phosphorylation and increased gluconeogenesis.

Parvaiz F, Manzoor S, Iqbal J, Sarkar-Dutta M, Imran M, Waris G.

World J Gastroenterol. 2015 Nov 21;21(43):12361-9. doi: 10.3748/wjg.v21.i43.12361.

4.

Hepatitis C virus NS5A protein interacts with beta-catenin and stimulates its transcriptional activity in a phosphoinositide-3 kinase-dependent fashion.

Milward A, Mankouri J, Harris M.

J Gen Virol. 2010 Feb;91(Pt 2):373-81. doi: 10.1099/vir.0.015305-0. Epub 2009 Oct 21.

PMID:
19846673
6.

A comparative cell biological analysis reveals only limited functional homology between the NS5A proteins of hepatitis C virus and GB virus B.

Mankouri J, Milward A, Pryde KR, Warter L, Martin A, Harris M.

J Gen Virol. 2008 Aug;89(Pt 8):1911-20. doi: 10.1099/vir.0.2008/001131-0.

PMID:
18632962
7.

Enhancement of canonical Wnt/β-catenin signaling activity by HCV core protein promotes cell growth of hepatocellular carcinoma cells.

Liu J, Ding X, Tang J, Cao Y, Hu P, Zhou F, Shan X, Cai X, Chen Q, Ling N, Zhang B, Bi Y, Chen K, Ren H, Huang A, He TC, Tang N.

PLoS One. 2011;6(11):e27496. doi: 10.1371/journal.pone.0027496. Epub 2011 Nov 15.

8.

Localization determines function: N-terminally truncated NS5A fragments accumulate in the nucleus and impair HCV replication.

Sauter D, Himmelsbach K, Kriegs M, Carvajal Yepes M, Hildt E.

J Hepatol. 2009 May;50(5):861-71. doi: 10.1016/j.jhep.2008.11.024. Epub 2009 Jan 31.

PMID:
19307038
9.

Zinc mesoporphyrin induces rapid proteasomal degradation of hepatitis C nonstructural 5A protein in human hepatoma cells.

Hou W, Tian Q, Zheng J, Bonkovsky HL.

Gastroenterology. 2010 May;138(5):1909-19. doi: 10.1053/j.gastro.2009.11.001. Epub 2009 Nov 10.

10.

Hepatitis C virus core protein activates Wnt/β-catenin signaling through multiple regulation of upstream molecules in the SMMC-7721 cell line.

Liu J, Wang Z, Tang J, Tang R, Shan X, Zhang W, Chen Q, Zhou F, Chen K, Huang A, Tang N.

Arch Virol. 2011 Jun;156(6):1013-23. doi: 10.1007/s00705-011-0943-x. Epub 2011 Feb 22.

PMID:
21340743
11.

Hepatitis C Virus Protein Interaction Network Analysis Based on Hepatocellular Carcinoma.

Han Y, Niu J, Wang D, Li Y.

PLoS One. 2016 Apr 26;11(4):e0153882. doi: 10.1371/journal.pone.0153882. eCollection 2016.

12.

Hepatitis C virus-induced activation of β-catenin promotes c-Myc expression and a cascade of pro-carcinogenetic events.

Higgs MR, Lerat H, Pawlotsky JM.

Oncogene. 2013 Sep 26;32(39):4683-93. doi: 10.1038/onc.2012.484. Epub 2012 Oct 29.

PMID:
23108410
13.

HCV NS5A interacts with p53 and inhibits p53-mediated apoptosis.

Lan KH, Sheu ML, Hwang SJ, Yen SH, Chen SY, Wu JC, Wang YJ, Kato N, Omata M, Chang FY, Lee SD.

Oncogene. 2002 Jul 18;21(31):4801-11.

14.

The Hepatitis C virus NS5A protein activates a phosphoinositide 3-kinase-dependent survival signaling cascade.

Street A, Macdonald A, Crowder K, Harris M.

J Biol Chem. 2004 Mar 26;279(13):12232-41. Epub 2004 Jan 5.

15.
16.

The FUSE binding protein is a cellular factor required for efficient replication of hepatitis C virus.

Zhang Z, Harris D, Pandey VN.

J Virol. 2008 Jun;82(12):5761-73. doi: 10.1128/JVI.00064-08. Epub 2008 Apr 9.

17.

Subversion of cell signaling pathways by hepatitis C virus nonstructural 5A protein via interaction with Grb2 and P85 phosphatidylinositol 3-kinase.

He Y, Nakao H, Tan SL, Polyak SJ, Neddermann P, Vijaysri S, Jacobs BL, Katze MG.

J Virol. 2002 Sep;76(18):9207-17.

18.

Effect of interaction between hepatitis C virus NS5A and NS5B on hepatitis C virus RNA replication with the hepatitis C virus replicon.

Shimakami T, Hijikata M, Luo H, Ma YY, Kaneko S, Shimotohno K, Murakami S.

J Virol. 2004 Mar;78(6):2738-48.

19.

Pim Kinase Interacts with Nonstructural 5A Protein and Regulates Hepatitis C Virus Entry.

Park C, Min S, Park EM, Lim YS, Kang S, Suzuki T, Shin EC, Hwang SB.

J Virol. 2015 Oct;89(19):10073-86. doi: 10.1128/JVI.01707-15. Epub 2015 Jul 22.

20.

Vinexin β Interacts with Hepatitis C Virus NS5A, Modulating Its Hyperphosphorylation To Regulate Viral Propagation.

Xiong W, Yang J, Wang M, Wang H, Rao Z, Zhong C, Xin X, Mo L, Yu S, Shen C, Zheng C.

J Virol. 2015 Jul;89(14):7385-400. doi: 10.1128/JVI.00567-15. Epub 2015 May 13.

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