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STAT6 activation by Toxoplasma gondii infection induces the expression of Th2 C-C chemokine ligands and B clade serine protease inhibitors in macrophage.

Ahn HJ, Kim JY, Ryu KJ, Nam HW.

Parasitol Res. 2009 Oct;105(5):1445-53. doi: 10.1007/s00436-009-1577-8. Epub 2009 Aug 5.


IL-4 independent nuclear translocalization of STAT6 in HeLa cells by entry of Toxoplasma gondii.

Ahn HJ, Kim JY, Nam HW.

Korean J Parasitol. 2009 Jun;47(2):117-24. doi: 10.3347/kjp.2009.47.2.117. Epub 2009 May 27.


Anti-apoptotic effects of SERPIN B3 and B4 via STAT6 activation in macrophages after infection with Toxoplasma gondii.

Song KJ, Ahn HJ, Nam HW.

Korean J Parasitol. 2012 Mar;50(1):1-6. doi: 10.3347/kjp.2012.50.1.1. Epub 2012 Mar 6.


Afatinib Reduces STAT6 Signaling of Host ARPE-19 Cells Infected with Toxoplasma gondii.

Yang Z, Ahn HJ, Park YH, Nam HW.

Korean J Parasitol. 2016 Feb;54(1):31-8. doi: 10.3347/kjp.2016.54.1.31. Epub 2016 Feb 26.


Differential regulation of chemokine expression by Th1 and Th2 cytokines and mechanisms of eotaxin/CCL-11 expression in human airway smooth muscle cells.

Odaka M, Matsukura S, Kuga H, Kokubu F, Kasama T, Kurokawa M, Kawaguchi M, Ieki K, Suzuki S, Watanabe S, Homma T, Takeuchi H, Nohtomi K, Schleimer RP, Adachi M.

Int Arch Allergy Immunol. 2007;143 Suppl 1:84-8. Epub 2007 May 1.


Toxoplasma gondii rhoptry kinase ROP16 activates STAT3 and STAT6 resulting in cytokine inhibition and arginase-1-dependent growth control.

Butcher BA, Fox BA, Rommereim LM, Kim SG, Maurer KJ, Yarovinsky F, Herbert DR, Bzik DJ, Denkers EY.

PLoS Pathog. 2011 Sep;7(9):e1002236. doi: 10.1371/journal.ppat.1002236. Epub 2011 Sep 8.


JAK-STAT6 Pathway Inhibitors Block Eotaxin-3 Secretion by Epithelial Cells and Fibroblasts from Esophageal Eosinophilia Patients: Promising Agents to Improve Inflammation and Prevent Fibrosis in EoE.

Cheng E, Zhang X, Wilson KS, Wang DH, Park JY, Huo X, Yu C, Zhang Q, Spechler SJ, Souza RF.

PLoS One. 2016 Jun 16;11(6):e0157376. doi: 10.1371/journal.pone.0157376. eCollection 2016.


Impaired chromatin remodelling at STAT1-regulated promoters leads to global unresponsiveness of Toxoplasma gondii-infected macrophages to IFN-γ.

Lang C, Hildebrandt A, Brand F, Opitz L, Dihazi H, Lüder CG.

PLoS Pathog. 2012 Jan;8(1):e1002483. doi: 10.1371/journal.ppat.1002483. Epub 2012 Jan 19.


Interleukin-4-induced transcriptional activation by stat6 involves multiple serine/threonine kinase pathways and serine phosphorylation of stat6.

Pesu M, Takaluoma K, Aittomäki S, Lagerstedt A, Saksela K, Kovanen PE, Silvennoinen O.

Blood. 2000 Jan 15;95(2):494-502.


Growth factor and Th2 cytokine signaling pathways converge at STAT6 to promote arginase expression in progressive experimental visceral leishmaniasis.

Osorio EY, Travi BL, da Cruz AM, Saldarriaga OA, Medina AA, Melby PC.

PLoS Pathog. 2014 Jun 26;10(6):e1004165. doi: 10.1371/journal.ppat.1004165. eCollection 2014 Jun.


Proprotein convertase FURIN constrains Th2 differentiation and is critical for host resistance against Toxoplasma gondii.

Oksanen A, Aittomäki S, Jankovic D, Ortutay Z, Pulkkinen K, Hämäläinen S, Rokka A, Corthals GL, Watford WT, Junttila I, O'Shea JJ, Pesu M.

J Immunol. 2014 Dec 1;193(11):5470-9. doi: 10.4049/jimmunol.1401629. Epub 2014 Oct 29.


Ras/Erk pathway positively regulates Jak1/STAT6 activity and IL-4 gene expression in Jurkat T cells.

So EY, Oh J, Jang JY, Kim JH, Lee CE.

Mol Immunol. 2007 Jul;44(13):3416-26. Epub 2007 Apr 12. Erratum in: Mol Immunol. 2008 Feb;45(4):1197.


STAT6 signalling is important in CD8 T-cell activation and defence against Toxoplasma gondii infection in the brain.

Jin D, Takamoto M, Hu T, Taki S, Sugane K.

Immunology. 2009 Jun;127(2):187-95. doi: 10.1111/j.1365-2567.2008.02935.x. Epub 2008 Sep 13.


Interferons inhibit activation of STAT6 by interleukin 4 in human monocytes by inducing SOCS-1 gene expression.

Dickensheets HL, Venkataraman C, Schindler U, Donnelly RP.

Proc Natl Acad Sci U S A. 1999 Sep 14;96(19):10800-5.


Th2 Cytokines Augment IL-31/IL-31RA Interactions via STAT6-dependent IL-31RA Expression.

Edukulla R, Singh B, Jegga AG, Sontake V, Dillon SR, Madala SK.

J Biol Chem. 2015 May 22;290(21):13510-20. doi: 10.1074/jbc.M114.622126. Epub 2015 Apr 6.

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