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Kinases required in hepatitis C virus entry and replication highlighted by small interference RNA screening.

Trotard M, Lepère-Douard C, Régeard M, Piquet-Pellorce C, Lavillette D, Cosset FL, Gripon P, Le Seyec J.

FASEB J. 2009 Nov;23(11):3780-9. doi: 10.1096/fj.09-131920. Epub 2009 Jul 16.


Hepatitis C virus NS5A protein interacts with phosphatidylinositol 4-kinase type IIIalpha and regulates viral propagation.

Lim YS, Hwang SB.

J Biol Chem. 2011 Apr 1;286(13):11290-8. doi: 10.1074/jbc.M110.194472. Epub 2011 Feb 5.


The level of CD81 cell surface expression is a key determinant for productive entry of hepatitis C virus into host cells.

Koutsoudakis G, Herrmann E, Kallis S, Bartenschlager R, Pietschmann T.

J Virol. 2007 Jan;81(2):588-98. Epub 2006 Nov 1.


Hepatitis C virus entry depends on clathrin-mediated endocytosis.

Blanchard E, Belouzard S, Goueslain L, Wakita T, Dubuisson J, Wychowski C, Rouillé Y.

J Virol. 2006 Jul;80(14):6964-72.


Metabolism of phosphatidylinositol 4-kinase IIIα-dependent PI4P Is subverted by HCV and is targeted by a 4-anilino quinazoline with antiviral activity.

Bianco A, Reghellin V, Donnici L, Fenu S, Alvarez R, Baruffa C, Peri F, Pagani M, Abrignani S, Neddermann P, De Francesco R.

PLoS Pathog. 2012;8(3):e1002576. doi: 10.1371/journal.ppat.1002576. Epub 2012 Mar 8.


Discovery of selective small molecule type III phosphatidylinositol 4-kinase alpha (PI4KIIIα) inhibitors as anti hepatitis C (HCV) agents.

Leivers AL, Tallant M, Shotwell JB, Dickerson S, Leivers MR, McDonald OB, Gobel J, Creech KL, Strum SL, Mathis A, Rogers S, Moore CB, Botyanszki J.

J Med Chem. 2014 Mar 13;57(5):2091-106. doi: 10.1021/jm400781h. Epub 2013 Aug 14.


Cytosolic phospholipase A2 gamma is involved in hepatitis C virus replication and assembly.

Xu S, Pei R, Guo M, Han Q, Lai J, Wang Y, Wu C, Zhou Y, Lu M, Chen X.

J Virol. 2012 Dec;86(23):13025-37. doi: 10.1128/JVI.01785-12. Epub 2012 Sep 26.


Roles for endocytic trafficking and phosphatidylinositol 4-kinase III alpha in hepatitis C virus replication.

Berger KL, Cooper JD, Heaton NS, Yoon R, Oakland TE, Jordan TX, Mateu G, Grakoui A, Randall G.

Proc Natl Acad Sci U S A. 2009 May 5;106(18):7577-82. doi: 10.1073/pnas.0902693106. Epub 2009 Apr 17.


Mouse-specific residues of claudin-1 limit hepatitis C virus genotype 2a infection in a human hepatocyte cell line.

Haid S, Windisch MP, Bartenschlager R, Pietschmann T.

J Virol. 2010 Jan;84(2):964-75. doi: 10.1128/JVI.01504-09. Epub 2009 Nov 4.


Cell entry, efficient RNA replication, and production of infectious hepatitis C virus progeny in mouse liver-derived cells.

Frentzen A, Anggakusuma, Gürlevik E, Hueging K, Knocke S, Ginkel C, Brown RJ, Heim M, Dill MT, Kröger A, Kalinke U, Kaderali L, Kuehnel F, Pietschmann T.

Hepatology. 2014 Jan;59(1):78-88. doi: 10.1002/hep.26626. Epub 2013 Nov 18.


Hepatitis C virus enters human peripheral neuroblastoma cells - evidence for extra-hepatic cells sustaining hepatitis C virus penetration.

Bürgel B, Friesland M, Koch A, Manns MP, Wedemeyer H, Weissenborn K, Schulz-Schaeffer WJ, Pietschmann T, Steinmann E, Ciesek S.

J Viral Hepat. 2011 Aug;18(8):562-70. doi: 10.1111/j.1365-2893.2010.01339.x. Epub 2010 Jun 23.


High density lipoproteins facilitate hepatitis C virus entry through the scavenger receptor class B type I.

Voisset C, Callens N, Blanchard E, Op De Beeck A, Dubuisson J, Vu-Dac N.

J Biol Chem. 2005 Mar 4;280(9):7793-9. Epub 2005 Jan 4.


Suppression of hepatitis C virus replicon by RNA interference directed against the NS3 and NS5B regions of the viral genome.

Takigawa Y, Nagano-Fujii M, Deng L, Hidajat R, Tanaka M, Mizuta H, Hotta H.

Microbiol Immunol. 2004;48(8):591-8.


Inhibition of hepatitis C virus protein expression by RNA interference.

Sen A, Steele R, Ghosh AK, Basu A, Ray R, Ray RB.

Virus Res. 2003 Oct;96(1-2):27-35.


Inhibition of hepatitis C virus RNA replication by short hairpin RNA synthesized by T7 RNA polymerase in hepatitis C virus subgenomic replicons.

Hamazaki H, Ujino S, Miyano-Kurosaki N, Shimotohno K, Takaku H.

Biochem Biophys Res Commun. 2006 May 12;343(3):988-94. Epub 2006 Mar 29.


Polo-like kinase 1 is involved in hepatitis C virus replication by hyperphosphorylating NS5A.

Chen YC, Su WC, Huang JY, Chao TC, Jeng KS, Machida K, Lai MM.

J Virol. 2010 Aug;84(16):7983-93. doi: 10.1128/JVI.00068-10. Epub 2010 Jun 9.


Peroxisome proliferator-activated receptor alpha antagonism inhibits hepatitis C virus replication.

Rakic B, Sagan SM, Noestheden M, Bélanger S, Nan X, Evans CL, Xie XS, Pezacki JP.

Chem Biol. 2006 Jan;13(1):23-30.


La protein required for internal ribosome entry site-directed translation is a potential therapeutic target for hepatitis C virus replication.

Shirasaki T, Honda M, Mizuno H, Shimakami T, Okada H, Sakai Y, Murakami S, Wakita T, Kaneko S.

J Infect Dis. 2010 Jul 1;202(1):75-85. doi: 10.1086/653081.


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