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The hepatitis C virus core protein contains a BH3 domain that regulates apoptosis through specific interaction with human Mcl-1.

Mohd-Ismail NK, Deng L, Sukumaran SK, Yu VC, Hotta H, Tan YJ.

J Virol. 2009 Oct;83(19):9993-10006. doi: 10.1128/JVI.00509-09. Epub 2009 Jul 15.


Solution structure of prosurvival Mcl-1 and characterization of its binding by proapoptotic BH3-only ligands.

Day CL, Chen L, Richardson SJ, Harrison PJ, Huang DC, Hinds MG.

J Biol Chem. 2005 Feb 11;280(6):4738-44. Epub 2004 Nov 18.


Diva, a Bcl-2 homologue that binds directly to Apaf-1 and induces BH3-independent cell death.

Inohara N, Gourley TS, Carrio R, Muñiz M, Merino J, Garcia I, Koseki T, Hu Y, Chen S, Núñez G.

J Biol Chem. 1998 Dec 4;273(49):32479-86.


Sequence and helicity requirements for the proapoptotic activity of Bax BH3 peptides.

Shangary S, Oliver CL, Tillman TS, Cascio M, Johnson DE.

Mol Cancer Ther. 2004 Nov;3(11):1343-54.


Mcl-1 interacts with truncated Bid and inhibits its induction of cytochrome c release and its role in receptor-mediated apoptosis.

Clohessy JG, Zhuang J, de Boer J, Gil-Gómez G, Brady HJ.

J Biol Chem. 2006 Mar 3;281(9):5750-9. Epub 2005 Dec 27.


Puma(*)Mcl-1 interaction is not sufficient to prevent rapid degradation of Mcl-1.

Mei Y, Du W, Yang Y, Wu M.

Oncogene. 2005 Nov 3;24(48):7224-37.


Induction of apoptosis by the severe acute respiratory syndrome coronavirus 7a protein is dependent on its interaction with the Bcl-XL protein.

Tan YX, Tan TH, Lee MJ, Tham PY, Gunalan V, Druce J, Birch C, Catton M, Fu NY, Yu VC, Tan YJ.

J Virol. 2007 Jun;81(12):6346-55. Epub 2007 Apr 11.


The molecular mechanism of Noxa-induced mitochondrial dysfunction in p53-mediated cell death.

Seo YW, Shin JN, Ko KH, Cha JH, Park JY, Lee BR, Yun CW, Kim YM, Seol DW, Kim DW, Yin XM, Kim TH.

J Biol Chem. 2003 Nov 28;278(48):48292-9. Epub 2003 Sep 18.


JAB1 accelerates mitochondrial apoptosis by interaction with proapoptotic BclGs.

Liu X, Pan Z, Zhang L, Sun Q, Wan J, Tian C, Xing G, Yang J, Liu X, Jiang J, He F.

Cell Signal. 2008 Jan;20(1):230-40. Epub 2007 Oct 16.


Structure of the BH3 domains from the p53-inducible BH3-only proteins Noxa and Puma in complex with Mcl-1.

Day CL, Smits C, Fan FC, Lee EF, Fairlie WD, Hinds MG.

J Mol Biol. 2008 Jul 25;380(5):958-71. doi: 10.1016/j.jmb.2008.05.071. Epub 2008 Jun 4.


Regulation of apoptosis by BH3 domains in a cell-free system.

Cosulich SC, Worrall V, Hedge PJ, Green S, Clarke PR.

Curr Biol. 1997 Dec 1;7(12):913-20.


Mcl-1(128-350) fragment induces apoptosis through direct interaction with Bax.

Ménoret E, Gomez-Bougie P, Surget S, Trichet V, Oliver L, Pellat-Deceunynck C, Amiot M.

FEBS Lett. 2010 Feb 5;584(3):487-92. doi: 10.1016/j.febslet.2009.11.094. Epub 2009 Dec 4.

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