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APRIL and TACI interact with syndecan-1 on the surface of multiple myeloma cells to form an essential survival loop.

Moreaux J, Sprynski AC, Dillon SR, Mahtouk K, Jourdan M, Ythier A, Moine P, Robert N, Jourdan E, Rossi JF, Klein B.

Eur J Haematol. 2009 Aug;83(2):119-29. doi: 10.1111/j.1600-0609.2009.01262.x. Epub 2009 May 30.


APRIL is overexpressed in cancer: link with tumor progression.

Moreaux J, Veyrune JL, De Vos J, Klein B.

BMC Cancer. 2009 Mar 16;9:83. doi: 10.1186/1471-2407-9-83.


TACI, unlike BAFF-R, is solely activated by oligomeric BAFF and APRIL to support survival of activated B cells and plasmablasts.

Bossen C, Cachero TG, Tardivel A, Ingold K, Willen L, Dobles M, Scott ML, Maquelin A, Belnoue E, Siegrist CA, Chevrier S, Acha-Orbea H, Leung H, Mackay F, Tschopp J, Schneider P.

Blood. 2008 Feb 1;111(3):1004-12. Epub 2007 Oct 17.


Identification of proteoglycans as the APRIL-specific binding partners.

Ingold K, Zumsteg A, Tardivel A, Huard B, Steiner QG, Cachero TG, Qiang F, Gorelik L, Kalled SL, Acha-Orbea H, Rennert PD, Tschopp J, Schneider P.

J Exp Med. 2005 May 2;201(9):1375-83. Epub 2005 Apr 25.


Selectivity of BAFF/BLyS and APRIL for binding to the TNF family receptors BAFFR/BR3 and BCMA.

Day ES, Cachero TG, Qian F, Sun Y, Wen D, Pelletier M, Hsu YM, Whitty A.

Biochemistry. 2005 Feb 15;44(6):1919-31.


Synthetic CpG oligodeoxynucleotides augment BAFF- and APRIL-mediated immunoglobulin secretion.

Katsenelson N, Kanswal S, Puig M, Mostowski H, Verthelyi D, Akkoyunlu M.

Eur J Immunol. 2007 Jul;37(7):1785-95.


Expression of BCMA, TACI, and BAFF-R in multiple myeloma: a mechanism for growth and survival.

Novak AJ, Darce JR, Arendt BK, Harder B, Henderson K, Kindsvogel W, Gross JA, Greipp PR, Jelinek DF.

Blood. 2004 Jan 15;103(2):689-94. Epub 2003 Sep 25.


Tumor necrosis factor (TNF) receptor superfamily member TACI is a high affinity receptor for TNF family members APRIL and BLyS.

Wu Y, Bressette D, Carrell JA, Kaufman T, Feng P, Taylor K, Gan Y, Cho YH, Garcia AD, Gollatz E, Dimke D, LaFleur D, Migone TS, Nardelli B, Wei P, Ruben SM, Ullrich SJ, Olsen HS, Kanakaraj P, Moore PA, Baker KP.

J Biol Chem. 2000 Nov 10;275(45):35478-85.


Deficient TACI expression on B lymphocytes of newborn mice leads to defective Ig secretion in response to BAFF or APRIL.

Kanswal S, Katsenelson N, Selvapandiyan A, Bram RJ, Akkoyunlu M.

J Immunol. 2008 Jul 15;181(2):976-90. Erratum in: J Immunol. 2008 Oct 1;181(7):5174.


The rGel/BLyS fusion toxin specifically targets malignant B cells expressing the BLyS receptors BAFF-R, TACI, and BCMA.

Lyu MA, Cheung LH, Hittelman WN, Marks JW, Aguiar RC, Rosenblum MG.

Mol Cancer Ther. 2007 Feb;6(2):460-70. Epub 2007 Jan 31.


TACI regulates IgA production by APRIL in collaboration with HSPG.

Sakurai D, Hase H, Kanno Y, Kojima H, Okumura K, Kobata T.

Blood. 2007 Apr 1;109(7):2961-7.


Interaction of the TNF homologues BLyS and APRIL with the TNF receptor homologues BCMA and TACI.

Marsters SA, Yan M, Pitti RM, Haas PE, Dixit VM, Ashkenazi A.

Curr Biol. 2000 Jun 29;10(13):785-8.


APRIL and BAFF proteins increase proliferation of human adipose-derived stem cells through activation of Erk1/2 MAP kinase.

Zonca M, Mancheño-Corvo P, DelaRosa O, Mañes S, Büscher D, Lombardo E, Planelles L.

Tissue Eng Part A. 2012 Apr;18(7-8):852-9. doi: 10.1089/ten.TEA.2011.0316. Epub 2011 Dec 22.


Expressions of BAFF/BAFF receptors and their correlation with disease activity in Chinese SLE patients.

Zhao LD, Li Y, Smith MF Jr, Wang JS, Zhang W, Tang FL, Tian XP, Wang HY, Zhang FC, Ba DN, He W, Zhang X.

Lupus. 2010 Nov;19(13):1534-49. doi: 10.1177/0961203310375268.


Adipocytes as immune cells: differential expression of TWEAK, BAFF, and APRIL and their receptors (Fn14, BAFF-R, TACI, and BCMA) at different stages of normal and pathological adipose tissue development.

Alexaki VI, Notas G, Pelekanou V, Kampa M, Valkanou M, Theodoropoulos P, Stathopoulos EN, Tsapis A, Castanas E.

J Immunol. 2009 Nov 1;183(9):5948-56. doi: 10.4049/jimmunol.0901186. Epub 2009 Oct 14.


TACI expression is associated with a mature bone marrow plasma cell signature and C-MAF overexpression in human myeloma cell lines.

Moreaux J, Hose D, Jourdan M, Reme T, Hundemer M, Moos M, Robert N, Moine P, De Vos J, Goldschmidt H, Klein B.

Haematologica. 2007 Jun;92(6):803-11.


TACI, an enigmatic BAFF/APRIL receptor, with new unappreciated biochemical and biological properties.

Mackay F, Schneider P.

Cytokine Growth Factor Rev. 2008 Jun-Aug;19(3-4):263-76. doi: 10.1016/j.cytogfr.2008.04.006. Epub 2008 Jun 2. Review.


Atacicept (TACI-Ig) inhibits growth of TACI(high) primary myeloma cells in SCID-hu mice and in coculture with osteoclasts.

Yaccoby S, Pennisi A, Li X, Dillon SR, Zhan F, Barlogie B, Shaughnessy JD Jr.

Leukemia. 2008 Feb;22(2):406-13. Epub 2007 Nov 29.


B-lymphocyte stimulator/a proliferation-inducing ligand heterotrimers are elevated in the sera of patients with autoimmune disease and are neutralized by atacicept and B-cell maturation antigen-immunoglobulin.

Dillon SR, Harder B, Lewis KB, Moore MD, Liu H, Bukowski TR, Hamacher NB, Lantry MM, Maurer M, Krejsa CM, Ellsworth JL, Pederson S, Elkon KB, Wener MH, Dall'Era M, Gross JA.

Arthritis Res Ther. 2010;12(2):R48. doi: 10.1186/ar2959. Epub 2010 Mar 19.


No evidence that soluble TACI induces signalling via membrane-expressed BAFF and APRIL in myeloid cells.

Nys J, Smulski CR, Tardivel A, Willen L, Kowalczyk C, Donzé O, Huard B, Hess H, Schneider P.

PLoS One. 2013 Apr 19;8(4):e61350. doi: 10.1371/journal.pone.0061350. Print 2013.

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