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Items: 1 to 20 of 265


Intracellular parasitism with Toxoplasma gondii stimulates mammalian-target-of-rapamycin-dependent host cell growth despite impaired signalling to S6K1 and 4E-BP1.

Wang Y, Weiss LM, Orlofsky A.

Cell Microbiol. 2009 Jun;11(6):983-1000. doi: 10.1111/j.1462-5822.2009.01305.x. Epub 2009 Feb 27.


Rapamycin inhibits cell motility by suppression of mTOR-mediated S6K1 and 4E-BP1 pathways.

Liu L, Li F, Cardelli JA, Martin KA, Blenis J, Huang S.

Oncogene. 2006 Nov 9;25(53):7029-40. Epub 2006 May 22.


Determinants of rapamycin sensitivity in breast cancer cells.

Noh WC, Mondesire WH, Peng J, Jian W, Zhang H, Dong J, Mills GB, Hung MC, Meric-Bernstam F.

Clin Cancer Res. 2004 Feb 1;10(3):1013-23.


TOS motif-mediated raptor binding regulates 4E-BP1 multisite phosphorylation and function.

Schalm SS, Fingar DC, Sabatini DM, Blenis J.

Curr Biol. 2003 May 13;13(10):797-806.


S6K1 and 4E-BP1 are independent regulated and control cellular growth in bladder cancer.

Nawroth R, Stellwagen F, Schulz WA, Stoehr R, Hartmann A, Krause BJ, Gschwend JE, Retz M.

PLoS One. 2011;6(11):e27509. doi: 10.1371/journal.pone.0027509. Epub 2011 Nov 15.


Activation of the Akt/mammalian target of rapamycin/4E-BP1 pathway by ErbB2 overexpression predicts tumor progression in breast cancers.

Zhou X, Tan M, Stone Hawthorne V, Klos KS, Lan KH, Yang Y, Yang W, Smith TL, Shi D, Yu D.

Clin Cancer Res. 2004 Oct 15;10(20):6779-88.


Identification of a conserved motif required for mTOR signaling.

Schalm SS, Blenis J.

Curr Biol. 2002 Apr 16;12(8):632-9.


mTOR controls cell cycle progression through its cell growth effectors S6K1 and 4E-BP1/eukaryotic translation initiation factor 4E.

Fingar DC, Richardson CJ, Tee AR, Cheatham L, Tsou C, Blenis J.

Mol Cell Biol. 2004 Jan;24(1):200-16.


Immediate response of mammalian target of rapamycin (mTOR)-mediated signalling following acute resistance exercise in rat skeletal muscle.

Bolster DR, Kubica N, Crozier SJ, Williamson DL, Farrell PA, Kimball SR, Jefferson LS.

J Physiol. 2003 Nov 15;553(Pt 1):213-20. Epub 2003 Aug 22.


Phosphorylation dynamics of eukaryotic initiation factor 4E binding protein 1 (4E-BP1) is discordant with its potential to interact with eukaryotic initiation factor 4E (eIF4E).

Showkat M, Beigh MA, Bhat BB, Batool A, Andrabi KI.

Cell Signal. 2014 Oct;26(10):2117-21. doi: 10.1016/j.cellsig.2014.06.008. Epub 2014 Jun 26.


Assessment of cell-signaling pathways in the regulation of mammalian target of rapamycin (mTOR) by amino acids in rat adipocytes.

Pham PT, Heydrick SJ, Fox HL, Kimball SR, Jefferson LS Jr, Lynch CJ.

J Cell Biochem. 2000 Sep 7;79(3):427-41.


S6K1 is involved in polyploidization through its phosphorylation at Thr421/Ser424.

Ma D, Yu H, Lin D, Sun Y, Liu L, Liu Y, Dai B, Chen W, Cao J.

J Cell Physiol. 2009 Apr;219(1):31-44. doi: 10.1002/jcp.21647.


Activation of the mammalian target of rapamycin pathway acutely inhibits insulin signaling to Akt and glucose transport in 3T3-L1 and human adipocytes.

Tremblay F, Gagnon A, Veilleux A, Sorisky A, Marette A.

Endocrinology. 2005 Mar;146(3):1328-37. Epub 2004 Dec 2.


Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling.

Tee AR, Fingar DC, Manning BD, Kwiatkowski DJ, Cantley LC, Blenis J.

Proc Natl Acad Sci U S A. 2002 Oct 15;99(21):13571-6. Epub 2002 Sep 23.


S6 kinase 1 knockout inhibits uninephrectomy- or diabetes-induced renal hypertrophy.

Chen JK, Chen J, Thomas G, Kozma SC, Harris RC.

Am J Physiol Renal Physiol. 2009 Sep;297(3):F585-93. doi: 10.1152/ajprenal.00186.2009. Epub 2009 May 27.


Regulation of targets of mTOR (mammalian target of rapamycin) signalling by intracellular amino acid availability.

Beugnet A, Tee AR, Taylor PM, Proud CG.

Biochem J. 2003 Jun 1;372(Pt 2):555-66. Erratum in: Biochem J. 2003 Aug 1;373(Pt 3):999.


Inhibition of insulin signaling and adipogenesis by rapamycin: effect on phosphorylation of p70 S6 kinase vs eIF4E-BP1.

El-Chaâr D, Gagnon A, Sorisky A.

Int J Obes Relat Metab Disord. 2004 Feb;28(2):191-8.


Rotenone induction of hydrogen peroxide inhibits mTOR-mediated S6K1 and 4E-BP1/eIF4E pathways, leading to neuronal apoptosis.

Zhou Q, Liu C, Liu W, Zhang H, Zhang R, Liu J, Zhang J, Xu C, Liu L, Huang S, Chen L.

Toxicol Sci. 2015 Jan;143(1):81-96. doi: 10.1093/toxsci/kfu211. Epub 2014 Oct 9.

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