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CD8 T cells utilize TRAIL to control influenza virus infection.

Brincks EL, Katewa A, Kucaba TA, Griffith TS, Legge KL.

J Immunol. 2008 Oct 1;181(7):4918-25. Erratum in: J Immunol. 2008 Nov 15;181(10)7428.


The magnitude of the T cell response to a clinically significant dose of influenza virus is regulated by TRAIL.

Brincks EL, Gurung P, Langlois RA, Hemann EA, Legge KL, Griffith TS.

J Immunol. 2011 Nov 1;187(9):4581-8. doi: 10.4049/jimmunol.1002241. Epub 2011 Sep 21.


Plasmacytoid dendritic cells enhance mortality during lethal influenza infections by eliminating virus-specific CD8 T cells.

Langlois RA, Legge KL.

J Immunol. 2010 Apr 15;184(8):4440-6. doi: 10.4049/jimmunol.0902984. Epub 2010 Mar 10.


A role for IL-15 in the migration of effector CD8 T cells to the lung airways following influenza infection.

Verbist KC, Cole CJ, Field MB, Klonowski KD.

J Immunol. 2011 Jan 1;186(1):174-82. doi: 10.4049/jimmunol.1002613. Epub 2010 Nov 22.


The Flavonoid Isoliquiritigenin Reduces Lung Inflammation and Mouse Morbidity during Influenza Virus Infection.

Traboulsi H, Cloutier A, Boyapelly K, Bonin MA, Marsault É, Cantin AM, Richter MV.

Antimicrob Agents Chemother. 2015 Oct;59(10):6317-27. doi: 10.1128/AAC.01098-15. Epub 2015 Jul 27.


Tc17, a unique subset of CD8 T cells that can protect against lethal influenza challenge.

Hamada H, Garcia-Hernandez Mde L, Reome JB, Misra SK, Strutt TM, McKinstry KK, Cooper AM, Swain SL, Dutton RW.

J Immunol. 2009 Mar 15;182(6):3469-81. doi: 10.4049/jimmunol.0801814.


17β-estradiol protects females against influenza by recruiting neutrophils and increasing virus-specific CD8 T cell responses in the lungs.

Robinson DP, Hall OJ, Nilles TL, Bream JH, Klein SL.

J Virol. 2014 May;88(9):4711-20. doi: 10.1128/JVI.02081-13. Epub 2014 Feb 12.


Airway-Resident Memory CD8 T Cells Provide Antigen-Specific Protection against Respiratory Virus Challenge through Rapid IFN-γ Production.

McMaster SR, Wilson JJ, Wang H, Kohlmeier JE.

J Immunol. 2015 Jul 1;195(1):203-9. doi: 10.4049/jimmunol.1402975. Epub 2015 May 29.


Deficiency of the NOD-Like Receptor NLRC5 Results in Decreased CD8+ T Cell Function and Impaired Viral Clearance.

Lupfer CR, Stokes KL, Kuriakose T, Kanneganti TD.

J Virol. 2017 Aug 10;91(17). pii: e00377-17. doi: 10.1128/JVI.00377-17. Print 2017 Sep 1.


NK cells regulate CD8+ T cell priming and dendritic cell migration during influenza A infection by IFN-γ and perforin-dependent mechanisms.

Ge MQ, Ho AW, Tang Y, Wong KH, Chua BY, Gasser S, Kemeny DM.

J Immunol. 2012 Sep 1;189(5):2099-109. doi: 10.4049/jimmunol.1103474. Epub 2012 Aug 6.


Oseltamivir Prophylaxis Reduces Inflammation and Facilitates Establishment of Cross-Strain Protective T Cell Memory to Influenza Viruses.

Bird NL, Olson MR, Hurt AC, Oshansky CM, Oh DY, Reading PC, Chua BY, Sun Y, Tang L, Handel A, Jackson DC, Turner SJ, Thomas PG, Kedzierska K.

PLoS One. 2015 Jun 18;10(6):e0129768. doi: 10.1371/journal.pone.0129768. eCollection 2015.


Multiple redundant effector mechanisms of CD8+ T cells protect against influenza infection.

Hamada H, Bassity E, Flies A, Strutt TM, Garcia-Hernandez Mde L, McKinstry KK, Zou T, Swain SL, Dutton RW.

J Immunol. 2013 Jan 1;190(1):296-306. doi: 10.4049/jimmunol.1200571. Epub 2012 Nov 28.


Coinfection with Streptococcus pneumoniae negatively modulates the size and composition of the ongoing influenza-specific CD8⁺ T cell response.

Blevins LK, Wren JT, Holbrook BC, Hayward SL, Swords WE, Parks GD, Alexander-Miller MA.

J Immunol. 2014 Nov 15;193(10):5076-87. doi: 10.4049/jimmunol.1400529. Epub 2014 Oct 13.


Fatal outcome of pandemic H1N1 2009 influenza virus infection is associated with immunopathology and impaired lung repair, not enhanced viral burden, in pregnant mice.

Marcelin G, Aldridge JR, Duan S, Ghoneim HE, Rehg J, Marjuki H, Boon AC, McCullers JA, Webby RJ.

J Virol. 2011 Nov;85(21):11208-19. doi: 10.1128/JVI.00654-11. Epub 2011 Aug 24.


Fewer T lymphocytes and decreased pulmonary influenza virus burden in mice exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD).

Lawrence BP, Warren TK, Luong H.

J Toxicol Environ Health A. 2000 Sep 15;61(1):39-53.


Unlike CD4+ T-cell help, CD28 costimulation is necessary for effective primary CD8+ T-cell influenza-specific immunity.

Seah SG, Carrington EM, Ng WC, Belz GT, Brady JL, Sutherland RM, Hancock MS, La Gruta NL, Brown LE, Turner SJ, Zhan Y, Lew AM.

Eur J Immunol. 2012 Jul;42(7):1744-54. doi: 10.1002/eji.201142211. Epub 2012 Jun 14.


CD8+ T cells use TRAIL to restrict West Nile virus pathogenesis by controlling infection in neurons.

Shrestha B, Pinto AK, Green S, Bosch I, Diamond MS.

J Virol. 2012 Sep;86(17):8937-48. doi: 10.1128/JVI.00673-12. Epub 2012 Jun 27.


Systemic immunological tolerance to ocular antigens is mediated by TRAIL-expressing CD8+ T cells.

Griffith TS, Brincks EL, Gurung P, Kucaba TA, Ferguson TA.

J Immunol. 2011 Jan 15;186(2):791-8. doi: 10.4049/jimmunol.1002678. Epub 2010 Dec 17.


Granzyme B regulates antiviral CD8+ T cell responses.

Salti SM, Hammelev EM, Grewal JL, Reddy ST, Zemple SJ, Grossman WJ, Grayson MH, Verbsky JW.

J Immunol. 2011 Dec 15;187(12):6301-9. doi: 10.4049/jimmunol.1100891. Epub 2011 Nov 14.

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